Results 1 to 10 of about 9,983 (198)

Clinical Applications of Substance P (Neurokinin-1 Receptor) Antagonist in Canine Medicine [PDF]

Archives of Razi Institute, 2021
Substance P binds to the Neurokinin-1 (NK-1) receptors found in the emetic center of the central nervous system (CNS) to induce emesis. Maropitant is a selective NK-1 receptor antagonist that inhibits the binding of substance P to NK-1 receptors and is ...
K Sharun, K Jambagi, M Arya, . Aakanksha, S. N Chaithra, P. K Patel, S. K Dixit, K Dhama   +7 more
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Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation

Frontiers in Molecular Neuroscience, 2023
The tachykinin hemokinin-1 (HK-1) is involved in immunological processes, inflammation, and pain. Although the neurokinin 1 receptor (NK1R) is described as its main target, several effects are mediated by currently unidentified receptor(s).
Krisztina Takács-Lovász, Timea Aczél, Éva Borbély, Éva Borbély, Éva Szőke, Éva Szőke, Éva Szőke, Lilla Czuni, Péter Urbán, Attila Gyenesei, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, Zsuzsanna Helyes, József Kun, József Kun, Kata Bölcskei   +16 more
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Medullary tachykinin precursor 1 neurons promote rhythmic breathing

eLife, 2023
Rhythmic breathing is generated by neural circuits located in the brainstem. At its core is the preBötzinger Complex (preBötC), a region of the medulla, necessary for the generation of rhythmic breathing in mammals.
Jean-Philippe Rousseau, Andreea Furdui, Carolina da Silveira Scarpellini, Richard L Horner, Gaspard Montandon   +4 more
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The Contribution of Phospholipase C in Vomiting in the Least Shrew (Cryptotis Parva) Model of Emesis

Frontiers in Pharmacology, 2021
Gq and Gβγ protein-dependent phospholipase C (PLC) activation is extensively involved in G protein-coupled receptor (GPCR)-mediated signaling pathways which are implicated in a wide range of physiological and pathological events.
Weixia Zhong, Nissar A. Darmani
doaj   +1 more source

Hot flashes: Why? [PDF]

Romanian Medical Journal, 2021
Hot flashes (HF), transitory episodes of erythema, heat sensation, anxiety followed by chills, are described in carcinoid syndrome, mastocytosis, medullary thyroid cancer, hyperthyroidism, pheochromocytoma, alcohol consumption, side effects of drugs, and
Florica Sandru, Mihai Cristian Dumitrascu, Eugenia Petrova, Anda Dumitrascu, Claudiu Tupea, Mara Carsote, Adina Ghemigian, Ana Valea   +7 more
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Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

Cell Reports, 2020
Summary: Efficient Ca2+ flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs).
Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Jr., Adriana T. Larregina   +12 more
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The effects of simulated childbirth trauma on the gene expression of neurotransmitter receptors in the bladder of female rats

Journal of the Formosan Medical Association, 2021
Background/Purpose: To investigate the effects of simulated childbirth on the gene expression of parasympathetic muscarinic, purinergic (P2X), and neurokinin receptors of lower urinary tract in rats.
Cheng-Yu Long, Kun-Ling Lin, Zi-Xi Loo, Chin-Ru Ker, Ming-Ping Wu, Yung-Chin Lee   +5 more
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Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain

Molecular Pain, 2021
Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic
Jacob CA Edvinsson, Philip V Reducha, Majid Sheykhzade, Karin Warfvinge, Kristian A Haanes, Lars Edvinsson   +5 more
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Cardioprotective action of aprepitant in a rat model of ischemia-reperfusioninduced myocardial injury: role of PI3K-AkT-GSK-3β-HIF-1α signaling pathway

Acta Cirúrgica Brasileira, 2022
Purpose: The present study explored the role and mechanism involved in aprepitant-induced cardioprotective effects in rat model of ischemia-reperfusion injury.
Mei Qian, Yang Liu
doaj   +1 more source

Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ. [PDF]

PLoS ONE, 2015
Keratocytes, the quiescent cells of the corneal stroma, play a crucial role in corneal wound healing. Neuropeptides and neurotransmitters are usually associated with neuronal signaling, but have recently been shown to be produced also by non-neuronal ...
Marta Słoniecka, Sandrine Le Roux, Peter Boman, Berit Byström, Qingjun Zhou, Patrik Danielson   +5 more
doaj   +1 more source