Results 21 to 30 of about 10,275 (190)
Substance P selectively decreases paired pulse depression in the rat hippocampal slice
BMC Neuroscience, 2005 Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from ...
Davies Stephen N, Wease Kerrie N
doaj +1 more source
Neurokinin receptors in the gastrointestinal muscle wall: cell distribution and possible roles
Biomolecular Concepts, 2013 The neurokinin receptors are G-protein-linked receptors; three distinct molecules, called neurokinin-1, neurokinin-2, and neurokinin-3 receptors, have been identified.
Vannucchi Maria Giuliana +1 more
doaj +1 more source
Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
Nature Communications, 2019 Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically ...
Jendrik Schöppe +6 more
doaj +1 more source
From bench to bedside: The role of cough hypersensitivity in chronic cough
Clinical and Translational Medicine, 2023 Background Chronic cough is a burdensome condition characterized by persistent cough lasting longer than 8 weeks. Chronic cough can significantly affect quality of life, physical function and productivity, with many people troubled with a cough that ...
Matthew G. Drake +2 more
doaj +1 more source
Peptide Receptor Radionuclide Therapy and Primary Brain Tumors: An Overview
Pharmaceuticals, 2021 Primary brain tumors (PBTs) are some of the most difficult types of cancer to treat, and despite advancements in surgery, chemotherapy and radiotherapy, new strategies for the treatment of PBTs are needed, especially for those with poor prognosis such as
Andrea Cimini +7 more
doaj +1 more source
A New Generation of Treatments for Itch
Acta Dermato-Venereologica, 2020 For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch.
Emilie Fowler, Gil Yosipovitch
doaj +1 more source
Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights
International Journal of Inflammation, 2010 Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved.
Akhil Hegde +3 more
doaj +1 more source
Remote control of respiratory neural network by spinal locomotor generators.
PLoS ONE, 2014 During exercise and locomotion, breathing rate rapidly increases to meet the suddenly enhanced oxygen demand. The extent to which direct central interactions between the spinal networks controlling locomotion and the brainstem networks controlling ...
Jean-Patrick Le Gal +4 more
doaj +1 more source
Frontiers in Physiology, 2022 With many common bladder diseases arising due to abnormal contractions, a greater understanding of the receptor systems involved may aid the development of future treatments.
Charlotte Phelps +2 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Situational syncope, which includes rectally mediated reflexes, is defined as syncope induced by a specific situation. Its pathogenesis generally involves disorders of the autonomic nervous system.
Kentaro Kurogochi +3 more
doaj +1 more source