Results 21 to 30 of about 9,983 (198)
Neurokinin receptors in the gastrointestinal muscle wall: cell distribution and possible roles
Biomolecular Concepts, 2013 The neurokinin receptors are G-protein-linked receptors; three distinct molecules, called neurokinin-1, neurokinin-2, and neurokinin-3 receptors, have been identified.
Vannucchi Maria Giuliana +1 more
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Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists
Nature Communications, 2019 Neurokinin receptors are G protein-coupled receptors. Here the authors present three crystal structures of the neurokinin 1 receptor (NK1R) in complex with small-molecule antagonists including aprepitant and netupitant and observe that these clinically ...
Jendrik Schöppe +6 more
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From bench to bedside: The role of cough hypersensitivity in chronic cough
Clinical and Translational Medicine, 2023 Background Chronic cough is a burdensome condition characterized by persistent cough lasting longer than 8 weeks. Chronic cough can significantly affect quality of life, physical function and productivity, with many people troubled with a cough that ...
Matthew G. Drake +2 more
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Peptide Receptor Radionuclide Therapy and Primary Brain Tumors: An Overview
Pharmaceuticals, 2021 Primary brain tumors (PBTs) are some of the most difficult types of cancer to treat, and despite advancements in surgery, chemotherapy and radiotherapy, new strategies for the treatment of PBTs are needed, especially for those with poor prognosis such as
Andrea Cimini +7 more
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A New Generation of Treatments for Itch
Acta Dermato-Venereologica, 2020 For decades, antihistamines have been the mainstay of treatment for chronic pruritus, yet they often only work by making patients drowsy and forgetful of their itch.
Emilie Fowler, Gil Yosipovitch
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Neurokinin-1 Receptor Antagonist Treatment in Polymicrobial Sepsis: Molecular Insights
International Journal of Inflammation, 2010 Neurokinin-1 receptor blocking has been shown to be beneficial against lung injury in polymicrobial sepsis. In this paper, we evaluated the possible mediators and the mechanism involved.
Akhil Hegde +3 more
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Remote control of respiratory neural network by spinal locomotor generators.
PLoS ONE, 2014 During exercise and locomotion, breathing rate rapidly increases to meet the suddenly enhanced oxygen demand. The extent to which direct central interactions between the spinal networks controlling locomotion and the brainstem networks controlling ...
Jean-Patrick Le Gal +4 more
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Frontiers in Physiology, 2022 With many common bladder diseases arising due to abnormal contractions, a greater understanding of the receptor systems involved may aid the development of future treatments.
Charlotte Phelps +2 more
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Frontiers in Pharmacology, 2022 Situational syncope, which includes rectally mediated reflexes, is defined as syncope induced by a specific situation. Its pathogenesis generally involves disorders of the autonomic nervous system.
Kentaro Kurogochi +3 more
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Management of chemotherapy induced emesis [PDF]
Archive of Oncology, 2004 Important progress has been achieved in the last few years in the prevention of chemotherapy-induced nausea and vomiting thanks to the introduction in clinical practice first of the 5-HT3 antagonists and of the NK1 antagonists more recently.
Roila Fausto
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