Results 11 to 20 of about 9,983 (198)

Neurokinin-1 receptor activation in globus pallidus [PDF]

Frontiers in Neuroscience, 2009
The undecapeptide substance P has been demonstrated to modulate neuronal activity in a number of brain regions by acting on neurokinin-1 receptors. Anatomical studies revealed a moderate level of neurokinin-1 receptor in rat globus pallidus. To determine
Lei Chen, Lei Chen, Qiao-Ling Cui, Qiao-Ling Cui, Wing-Ho Yung   +4 more
doaj   +3 more sources

Neurokinin 1 Receptor Antagonists for Pruritus [PDF]

Drugs, 2021
Pruritus, commonly known as itch, is a very common symptom in numerous dermatological disorders and systemic diseases. It can manifest as acute, or when lasting longer than 6 weeks, it is considered chronic and can lead to significant distress and reduced quality-of-life of those suffering.
Majid Alam, Joerg Buddenkotte, Fareed Ahmad, Martin Steinhoff   +3 more
openaire   +2 more sources

The Neurokinin-1 Receptor Is a Target in Pediatric Rhabdoid Tumors [PDF]

Current Oncology, 2021
Rhabdoid tumors (RT) are among the most aggressive tumors in early childhood. Overall survival remains poor, and treatment only effectively occurs at the cost of high toxicity and late adverse effects. It has been reported that the neurokinin-1 receptor/ substance P complex plays an important role in cancer and proved to be a promising target. However,
Julian Kolorz, Salih Demir, Adrian Gottschlich, Iris Beirith, Matthias Ilmer, Daniel Lüthy, Christoph Walz, Mario M. Dorostkar, Thomas Magg, Fabian Hauck, Dietrich von Schweinitz, Sebastian Kobold, Roland Kappler, Michael Berger   +13 more
openaire   +4 more sources

A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor‐mediated apoptosis in glioblastomas [PDF]

Journal of Neurochemistry, 2009
AbstractPrevious studies have shown that neurokinin 1 receptor (NK1R) occurs naturally in human glioblastomas and its stimulation causes cell proliferation. In the present study we show that stimulation of NK1R in human U373 glioblastoma cells by substance P increases Akt phosphorylation by 2.5‐fold, with an EC50of 57 nM.
Toshimasa, Akazawa, Shawn G, Kwatra, Laura E, Goldsmith, Mark D, Richardson, Elizabeth A, Cox, John H, Sampson, Madan M, Kwatra   +6 more
openaire   +2 more sources

Neurokinin-1 Receptor Antagonists against Hepatoblastoma [PDF]

Cancers, 2019
Hepatoblastoma (HB) is the most common malignant liver tumor that occurs during childhood. The prognosis of children with HB is favorable when a complete surgical resection of the tumor is possible, but for high-risk patients, the prognosis is much worse. New anti-HB strategies must be urgently developed.
Miguel Muñoz, Marisa Rosso, Rafael Coveñas   +2 more
openaire   +5 more sources

Neurokinin 1 receptor expression in the rat retina [PDF]

The Journal of Comparative Neurology, 1997
Tachykinin (TK) peptides influence neuronal activity in the inner retina of mammals. The aim of this investigation was to determine the cellular localization of the neurokinin 1 receptor (NK1), whose preferred ligand is the TK peptide substance P (SP), in the rat retina.
CASINI, GIOVANNI, RICKMAN D. W., STERNINI C., BRECHA N. C.   +3 more
openaire   +3 more sources

Neurokinin-1 Receptor Blockade and Murine Lung Tumorigenesis [PDF]

American Journal of Respiratory and Critical Care Medicine, 2006
Abstract Rationale Analogous to the adenoma-carcinoma sequence in the colon, it has been proposed that adenocarcinoma (AC) in the lung arises from adenomatous hyperplasia that progresses through atypical adenomatous hyperplasia to AC.
LUCATTELLI, M., FINESCHI, S., GEPPETTI, P., GERARD, N. P., LUNGARELLA, G.   +4 more
openaire   +4 more sources

The neuropeptide substance P regulates aldosterone secretion in human adrenals

Nature Communications, 2020
Adrenal aldosterone production is regulated by plasma angiotensin and potassium levels. Here the authors report that the neuropeptide substance P stimulates aldosterone production via neurokinin type 1 receptors (NK1R), and report a proof-of-concept ...
Julien Wils, Céline Duparc, Anne-Françoise Cailleux, Antoine-Guy Lopez, Caroline Guiheneuf, Isabelle Boutelet, Hadrien-Gaël Boyer, Christophe Dubessy, Saloua Cherifi, Bruno Cauliez, Françoise Gobet, Guillaume Defortescu, Jean-François Ménard, Estelle Louiset, Hervé Lefebvre   +14 more
doaj   +1 more source

Harnessing the Anti-Nociceptive Potential of NK2 and NK3 Ligands in the Design of New Multifunctional μ/δ-Opioid Agonist–Neurokinin Antagonist Peptidomimetics

Molecules, 2021
Opioid agonists are well-established analgesics, widely prescribed for acute but also chronic pain. However, their efficiency comes with the price of drastically impacting side effects that are inherently linked to their prolonged use.
Charlène Gadais, Justyna Piekielna-Ciesielska, Jolien De Neve, Charlotte Martin, Anna Janecka, Steven Ballet   +5 more
doaj   +1 more source

Substance P selectively decreases paired pulse depression in the rat hippocampal slice

BMC Neuroscience, 2005
Background Although being widespread in the hippocampus, the role tachykinins play in synaptic transmission is unclear. The effect of substance P on field potentials evoked by stimulation of the Schaffer collateral-commissural fibres and recorded from ...
Davies Stephen N, Wease Kerrie N
doaj   +1 more source