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Depression, Nutritional Status, and Substance P/NK-1R Biomarkers in Dysmenorrhea: A Randomized Crossover Trial. [PDF]

open access: yesDepress Anxiety
Mehboob R   +8 more
europepmc   +1 more source

The Role of Neuro-Immune Regulation in the Pathogenesis of Psoriasis. [PDF]

open access: yesJ Immunol Res
Liu X   +9 more
europepmc   +1 more source
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Safety of neurokinin-1 receptor antagonists

Expert Opinion on Drug Safety, 2013
The substance P (SP)/neurokinin (NK)-1 receptor system is involved in many pathological processes. NK-1 receptor antagonists have many promising therapeutic indications. However, the only NK-1 receptor antagonist used in clinical practice is the drug aprepitant and its intravenously administered prodrug, fosaprepitant.
Miguel, Muñoz, Rafael, Coveñas
openaire   +2 more sources

Neurokinin-1 Receptor Resensitization Precedes Receptor Recycling

The Journal of Pharmacology and Experimental Therapeutics, 2005
Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to require internalization and recycling.
V J, Bennett, S A, Perrine, M A, Simmons
openaire   +2 more sources

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