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Mast Cells and Substance P: Neuroinflammatory Loops at the Molecular and Translational Clinical Levels. [PDF]
Aitella E +5 more
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Depression, Nutritional Status, and Substance P/NK-1R Biomarkers in Dysmenorrhea: A Randomized Crossover Trial. [PDF]
Mehboob R +8 more
europepmc +1 more source
The Role of Neuro-Immune Regulation in the Pathogenesis of Psoriasis. [PDF]
Liu X +9 more
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Innovative Tools and Perspectives in Cough Management: Cancer and Cough. [PDF]
Choi J, Lee SY.
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Safety of neurokinin-1 receptor antagonists
Expert Opinion on Drug Safety, 2013The substance P (SP)/neurokinin (NK)-1 receptor system is involved in many pathological processes. NK-1 receptor antagonists have many promising therapeutic indications. However, the only NK-1 receptor antagonist used in clinical practice is the drug aprepitant and its intravenously administered prodrug, fosaprepitant.
Miguel, Muñoz, Rafael, Coveñas
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Neurokinin-1 Receptor Resensitization Precedes Receptor Recycling
The Journal of Pharmacology and Experimental Therapeutics, 2005Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to require internalization and recycling.
V J, Bennett, S A, Perrine, M A, Simmons
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