Results 151 to 160 of about 9,983 (198)
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Peptides, 2012
The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cell proliferation and inhibition in ...
Miguel, Muñoz +6 more
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The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cell proliferation and inhibition in ...
Miguel, Muñoz +6 more
openaire +2 more sources
Regulation of neurokinin-1 receptor expression by GABAB receptor agonists
Life Sciences, 1998Activation of GABA(B) receptors produces analgesia in acute and chronic pain models. Data indicate that a possible mechanism for this effect is a GABA(B) receptor-induced blockade of neurokinin-1 (NK-1) receptor gene expression in the spinal cord. While much more potent GABA(B) receptor agonists (CGP 44532) have been developed, there is no information ...
S J, Enna, E B, Harstad, K E, McCarson
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A selective and extremely potent antagonist of the neurokinin-1 receptor
Brain Research, 1992Sendide [Tyr6,D-Phe7,D-His9]-substance P(6-11) has been examined by measurements of ligand binding to crude membrane fractions and by functional tests on the spinally mediated behavioral response. Sendide potently displaced [3H]-labeled substance P (SP) binding to mouse spinal cord membranes in a competitive manner.
T, Sakurada +6 more
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Internalization of the neurokinin 1 receptor in rat myenteric neurons
Neuroscience, 1999Immunoreactivity for the neurokinin 1 receptor is contained in nerve cell bodies that have been deduced to be intrinsic primary afferent neurons in the myenteric plexus of the rat ileum. This study shows that neurokinin 1 receptor immunoreactivity on these neurons represents receptors that can bind agonist and undergo endocytosis, and explores the ...
P T, Mann, B R, Southwell, J B, Furness
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Neurokinin 1 receptor isoforms and the control of innate immunity
Trends in Immunology, 2009Substance P is the prototype tachykinin peptide and triggers a variety of biological effects in both the nervous and immune system. Two naturally occurring variants of the neurokinin 1 receptor (NK1R) mediate the effects of SP: a 'classic' full-length receptor and a truncated (tail-less) form that lacks 96 amino acid residues at the C-terminus.
Florin, Tuluc +4 more
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Endocytosis and recycling of neurokinin 1 receptors in enteric neurons
Neuroscience, 1996Neurotransmission depends on the availability of transmitter and on the presence of functional, high-affinity receptors at the plasma membrane that are capable of binding ligand. The pathway, mechanism and function of endocytosis and recycling of the substance P or neurokinin 1 receptor in enteric neurons were studied using fluorescent substance P ...
E F, Grady +6 more
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Substance P and neurokinin-1 receptor modulation of HIV
Journal of Neuroimmunology, 2004There is a high incidence of life event stress, depression, and associated symptoms in individuals with HIV infection/AIDS. Psychological and psychiatric symptomatology in individuals with HIV and AIDS may be related to the progression of AIDS disease.
Wen-Zhe, Ho, Steven D, Douglas
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Ontogeny of neurokinin-1 receptors in the porcine respiratory system
Peptides, 1999We characterized the ontogeny of NK-1 receptor agonist affinity (Kd) and density (Bmax) in membranes from tracheal epithelium, smooth muscle, and lung of pigs aged 1-7 days, 8-21 days, and adult in comparison to contractile responses in vitro. Affinity of [125I] Bolton-Hunter substance P ([125I]BH-SP) in epithelium and smooth muscle was three- to ...
M D, Yohannan +4 more
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Targeting Opioid and Neurokinin-1 Receptors to Treat Alcoholism
Current Medicinal Chemistry, 2011Alcoholism is a multifarious and ongoing disease tightly related to the amount of alcohol ingested, the drinking pattern, the history of alcohol drinking and the individual features, such as some genetic traits. Worldwide alcohol is the necessary cause of approximately 60 diseases and causes circa 2.5 million deaths every year.
F D, Rodriguez, R, Coveñas
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Complex allosteric interaction of heparin with neurokinin-1 receptors
European Journal of Pharmacology: Molecular Pharmacology, 1991The effects of several heparin preparations on rat striatal neurokinin-1 receptor labelling were investigated. A low concentration of heparin dose-dependently stimulated [125I]Bolton-Hunter substance P ([125I]BH-SP) binding to rat striatal membranes. This effect was mainly due to an increase of the association velocity reflected by a decrease of the ...
G A, Knaus, H G, Knaus, A, Saria
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