Results 141 to 150 of about 9,983 (198)

TRPA1 and TRPM8 in Allergic Rhinitis and Chronic Rhinosinusitis: Emerging Role in Neuroimmune Inflammation. [PDF]

Biomedicines
Kang T, Qiu Z, Aodeng S, Liu Y, Zhu Z, Lv W.   +5 more
europepmc   +1 more source

Role of Mast Cells and Neuroinflammation in Neuropsychiatric Disorders of the Developmental Period. [PDF]

Biomolecules
Aitella E, Neri L, Azzellino G, Romano C, De Martinis M, Roncone R, Ginaldi L.   +6 more
europepmc   +1 more source

Substance P and the neurokinin 1 receptor

, 2009
openaire   +1 more source

Integrating Models to Decode the GnRH Pulse Generator

Nechyporenko K, Ivanova D, Li XF, Tsaneva-Atanasova K, Voliotis M, O’Byrne KT.   +5 more
europepmc   +1 more source

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Safety of neurokinin-1 receptor antagonists

Expert Opinion on Drug Safety, 2013
The substance P (SP)/neurokinin (NK)-1 receptor system is involved in many pathological processes. NK-1 receptor antagonists have many promising therapeutic indications. However, the only NK-1 receptor antagonist used in clinical practice is the drug aprepitant and its intravenously administered prodrug, fosaprepitant.
Miguel, Muñoz, Rafael, Coveñas
openaire   +2 more sources

Neurokinin-1 Receptor Resensitization Precedes Receptor Recycling

The Journal of Pharmacology and Experimental Therapeutics, 2005
Following agonist binding, neurokinin-1 receptors undergo rapid desensitization followed by internalization and recycling. Desensitization requires receptor phosphorylation but does not require internalization, whereas resensitization is thought to require internalization and recycling.
V J, Bennett, S A, Perrine, M A, Simmons
openaire   +2 more sources

Expression of the neurokinin 1 receptor in the rabbit retina

Neuroscience, 2002
Substance P is the preferred ligand for the neurokinin 1 (NK1) receptor. In vertebrate retinas, substance P is expressed by amacrine, interplexiform and ganglion cells. Substance P influences the activity of amacrine and ganglion cells and it is reported to evoke dopamine release.
CASINI, GIOVANNI, SABATINI A., CATALANI E., WILLEMS D., BOSCO L., BRECHA N. C.   +5 more
openaire   +2 more sources

A Novel Mechanism of Neurokinin-1 Receptor Resensitization

The Journal of Pharmacology and Experimental Therapeutics, 2002
Prolonged or repeated activation of many G protein-coupled receptors induces rapid desensitization followed by a period during which receptors are resensitized. In this study, concanavalin A (Con A) and monensin were used to investigate the mechanisms of desensitization and resensitization of the neurokinin-1 receptor.
V J, Bennett, S A, Perrine, M A, Simmons
openaire   +2 more sources

Expression of the neurokinin 1 receptor in the mouse retina

Neuroscience, 2004
Previous studies have revealed that the expression pattern of the neurokinin 1 receptor (the preferred receptor for substance P, SP) varies in different mammalian retinas. We investigated NK1 receptor expression in the mouse retina to provide background information for future studies in transgenic mice on SP functional roles in the retina.
CATALANI E, GANGITANO C, BOSCO L., CASINI, GIOVANNI   +3 more
openaire   +4 more sources

The Neurokinin-1 Receptor in Addictive Processes

The Journal of Pharmacology and Experimental Therapeutics, 2014
Stress can trigger drug-seeking behavior, increase self-administration rates, and enhance drug reward. A number of stress-related neuropeptides have been shown to mediate these behavioral processes. The most studied peptide in this category is corticotropin-releasing hormone (CRH), which has been shown to mediate stress-induced reinstatement of drug ...
openaire   +2 more sources