Results 61 to 70 of about 10,275 (190)

Effects of general anesthetics on visceral pain transmission in the spinal cord

Molecular Pain, 2008
Current evidence suggests an analgesic role for the spinal cord action of general anesthetics; however, the cellular population and intracellular mechanisms underlying anti-visceral pain by general anesthetics still remain unclear.
Yue Yun, Nauta HJ, Lin Qing, Wu Jing, Wang Yun, Fang Li   +5 more
doaj   +1 more source

Neurokinin‐1 receptor antagonist (maropitant) for treatment of chronic idiopathic rhinitis in dogs: a pilot study

Journal of Small Animal Practice, EarlyView.
Objectives Chronic idiopathic rhinitis is a common canine nasal disease with unknown aetiology and poor response to treatment. Neurokinin‐1 receptor activation has been associated with rhinitis in experimental animals. The aim of this pilot study was to compare the effects of oral neurokinin‐1 receptor antagonist (maropitant) with placebo on clinical ...
H. Neittaanmäki, M. Rajamäki, N. Airas, A. Tilamaa, S. Viitanen   +4 more
wiley   +1 more source

Tachykinin Agonists Modulate Cholinergic Neurotransmission at Guinea-Pig Intracardiac Ganglia

Journal of Pharmacological Sciences, 2005
Effects of substance P (SP) and selective tachykinin agonists on neurotransmission at guinea-pig intracardiac ganglia were studied in vitro. Voltage responses of neurons to super-fused tachykinins and nerve stimulation were measured using intracellular ...
Lili Zhang, John C. Hancock, Donald B. Hoover   +2 more
doaj   +1 more source

Characterisation of sleep apneas and respiratory circuitry in mice lacking CDKL5

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary CDKL5 deficiency disorder is a rare genetic disease caused by mutations in the CDKL5 gene. Central apneas during wakefulness have been reported in patients with CDKL5 deficiency disorder. Studies on CDKL5‐knockout mice, a CDKL5 deficiency disorder model, reported sleep apneas, but it is still unclear whether these events are central (central ...
Gabriele Matteoli, Sara Alvente, Stefano Bastianini, Chiara Berteotti, Elisabetta Ciani, Elenia Cinelli, Viviana Lo Martire, Giorgio Medici, Tommaso Mello, Elena Miglioranza, Alessandro Silvani, Donatella Mutolo, Giovanna Zoccoli   +12 more
wiley   +1 more source

Spotlight on the perioperative use of maropitant citrate

Veterinary Medicine: Research and Reports, 2017
Bonnie L Hay Kraus Department of Veterinary Clinical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA, USA Abstract: Neurokinin-1 (NK-1) receptors are present in both the central nervous system and peripheral tissues. Substance P (
Hay Kraus BL
doaj  

The analgesic effects of botulinum neurotoxin by modulating pain-related receptors; A literature review

Molecular Pain
Botulinum neurotoxins (BoNTs), produced by Clostridium botulinum, have been used for the treatment of various central and peripheral neurological conditions.
Saereh Hosseindoost, Maziyar Askari Rad, Seyed Hassan Inanloo, Mojgan Rahimi, Samaneh Dehghan, Amirhossein Orandi, Ahmad Reza Dehpour, Hossein Majedi   +7 more
doaj   +1 more source

Effects of photobiomodulation therapy on pulmonary inflammation in chronic asthma: Dosimetric study in an experimental model

Photochemistry and Photobiology, EarlyView.
Photobiomodulation therapy (PBMT) was evaluated across a radiant energy range (1–7.5 J) in a murine model of chronic ovalbumin‐induced asthma to identify the optimal therapeutic dose. PBMT attenuated airway inflammation and remodelling, suppressed Th2 cytokines, and enhanced regulatory immune responses, highlighting a dose‐dependent immunomodulatory ...
Tawany Gonçalves Santos, Cintia Estefano Alves, Aurileia Aparecida de Brito, Bibiana Padilha de Menezes da Silva, Cinthya Cosme Gutierrez Duran, Stella Zamuner, Rodrigo Labat, José Antonio Silva Junior, Maria Cristina Chavantes, Flavio Aimbire, Renata Kelly da Palma, Ana Paula Ligeiro de Oliveira   +11 more
wiley   +1 more source

Overview of the neurokinin-1 receptor antagonists

Biotarget, 2017
Neurokinin-1 (NK-1) receptor antagonists block substance P-mediated NK-1 receptors which are present in the abdominal vagus, the brainstem, and the area postrema in the brainstem. Substance P is a mammalian tachykinin that is found in vagal afferent neurons innervating the brainstem and sends impulses to the vomiting center (1). Compounds that block NK-
openaire   +1 more source

Microvascular endothelial function is blunted in postmenopausal females with frequent hot flushes

Experimental Physiology, EarlyView.
Abstract Hot flushes of menopause are associated with elevated blood pressure (BP) and diminished macrovascular endothelial function, an initiating factor in the onset of atherosclerosis. Whether microvascular endothelial function is impaired in females with hot flushes, however, remains unknown.
William Stokes, Chowdhury Tasnova Tahsin, Miguel F. Anselmo, Stephany Nathe, Emma J. Lee, Soliana Teshome, Marnie L. Vanden Noven, Anne Blaes, Benjamin W. Langworthy, Manda L. Keller‐Ross   +9 more
wiley   +1 more source

High‐altitude headache: Insights into pathophysiology and potential treatment implications

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla, Florian Frank, Giacomo Strapazzon, Justin Lawley   +3 more
wiley   +1 more source