Results 131 to 140 of about 623,354 (235)

Transcriptomic profiling of subpopulations of mouse embryonic subplate neurons

Journal of Anatomy, EarlyView.
To study gene expression in subpopulations of cortical subplate neurons (Lpar1‐EGFP‐positive and D1B‐positive SpN clusters), we applied gene expression profiling, including bulk microarray analysis, single‐cell RNA sequencing (scRNA‐seq), and Visium spatial transcriptomics, and identified both overlapping and unique gene expression signatures ...
Hitomi Achiwa, Yuichiro Hara, Hideya Kawaji, Minori Oshima, Noe Kaneko, Ayumu Morioka, Anna Hoerder‐Suabedissen, Zoltán Molnár, Chiaki Ohtaka‐Maruyama   +8 more
wiley   +1 more source

Neuropeptides in the Management of Alzheimer's Disease: From Pathophysiology to Therapeutic Opportunities. [PDF]

Int J Mol Sci
Tiwari S, Yadav SK, Kumari M, Dhakal T, Puranik N.   +4 more
europepmc   +1 more source

Multiscale analysis of the adult human superior hypogastric plexus and hypogastric nerve

Journal of Anatomy, EarlyView.
Using tissue clearing and light‐sheet microscopy methods, we visualized the 3D mesoscopic arrangement of neural tracts, blood vessels and neurons within the adult human superior hypogastric plexus and hypogastric nerves, identifying the latter to contain thousands of neuronal cells bodies embedded along its entire length.
Kayleigh S. Scotcher, John‐Paul Fuller‐Jackson, Peregrine B. Osborne, Martin M. Bertrand, Janet R. Keast   +4 more
wiley   +1 more source

CD8⁺ tissue-resident memory cells- do they modulate peripheral nervous system and neuroinflammation? [PDF]

Front Immunol
Pandiyan P.
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Neuropeptide Y promotes myocardial fibrosis post myocardial infarction reperfusion through Neuropeptide Y receptor type 1. [PDF]

Clin Exp Med
Wang D, Wei B, Cao C, Xu Y, Gou W.
europepmc   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Evolutionary conservation and adaptability of cholecystokinin neuropeptide signaling in the sea cucumber Apostichopus japonicus. [PDF]

BMC Biol
Liu H, Yang H, Tian X, Elphick MR, Chen M.   +4 more
europepmc   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

The Translational Biology of Temporomandibular Disorder Pain: Mechanisms, Biomarkers, and Therapeutic Perspectives. [PDF]

J Pain Res
Firinciogullari EC, Alluri K, Yadav S.
europepmc   +1 more source