Results 101 to 110 of about 60,310 (240)

Early positive tactile stimulation reverses the increase of anxiety and decrease of sociality induced by early chronic mechanical pain in mandarin voles

Integrative Zoology, EarlyView.
This study used a tail‐pinching model during development to simulate mechanical pain experienced by pups in high‐social mandarin voles (Microtus mandarinus). Subsequently, brush‐like positive tactile stimuli were applied to the backs of the mandarin voles.
Yahan SUN, Jiayu XIAO, Luoman LI, Haiwei NIU, Yiting ZHU, Lu LI, Wei QIAN, Yin LI, Lizi ZHANG, Yishan QU, Yuting BAI, Xiao HAN, Kaizhe HUANG, Zhixiong HE, Fadao TAI   +14 more
wiley   +1 more source

Epidermal Collagen Reduction Drives Selective Aspects of Aging in Sensory Neurons

Aging Cell, Volume 24, Issue 4, April 2025.
Reduced collagen on the epidermal apical surface drives selective aging in sensory neurons of Caenorhabditis elegans, leading to excessive dendritic branching and related functional deficits. An immunoglobulin superfamily protein in interneurons acts upstream of collagen genes to maintain dendritic homeostasis during aging, with a downstream ...
Meera M. Krishna, Swapnil G. Waghmare, Ariel L. Franitza, Emily C. Maccoux, Lezi E   +4 more
wiley   +1 more source

Optimising Age‐Specific Insulin Signalling to Slow Down Reproductive Ageing Increases Fitness in Different Nutritional Environments

Aging Cell, Volume 24, Issue 5, May 2025.
We found that reducing insulin signalling in adult worms slows down their reproductive ageing and extends their lifespan without negative side effects. Moreover, combining it with IF further enhances these benefits. These interventions likely work by regulating genes linked to biosynthesis and immunity, showing how optimising gene expression can delay ...
Zahida Sultanova, Aykut Shen, Katarzyna Hencel, Hanne Carlsson, Zoe Crighton, Daniel Clifton, Alper Akay, Alexei A. Maklakov   +7 more
wiley   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide Orchestrates Neuronal Regulation Of The Astrocytic Glutamate-Releasing Mechanism System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e [PDF]

, 2016
Glutamate signaling is achieved by an elaborate network involving neurons and astrocytes. Hence, it is critical to better understand how neurons and astrocytes interact to coordinate the cellular regulation of glutamate signaling.
Albano, Rebecca, Baker, David A., Choi, Sujean, Kong, Linghai, Lobner, Doug, Madayag, Aric, Mantsch, John R., Raddatz, Nicholas   +7 more
core   +1 more source

Age‐Dependent Regulation of Hippocampal Inflammation by the Mitochondrial Translocator Protein in Mice

Aging Cell, EarlyView.
The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai, Jia Hui Wong, Nevin Tham, Lauren Fairley, Roshan Ratnakar Naik, Yulan Wang, Sarah R. Langley, Anna M. Barron   +7 more
wiley   +1 more source

Cortistain is expressed in a distinct subset of cortical interneurons [PDF]

, 1997
Cortistatin is a presumptive neuropeptide that shares 11 of its 14 amino acids with somatostatin. In contrast to somatostatin, administration of cortistatin into the rat brain ventricles specifically enhances slow wave sleep, apparently by antagonizing ...
Alcántara Horrillo, Soledad, Criado, José R., Danielson, Patria E., Henriksen, Steven J., Lecea Flores de Lemus, Luis de, Morales, Marisela, Río Fernández, José Antonio del, Soriano García, Eduardo, Sutcliffe, J. Gregor   +8 more
core  

The Proprotein Convertase BLI‐4 Is Required for Axenic Dietary Restriction Mediated Longevity in Caenorhabditis elegans

Aging Cell, EarlyView.
In ADR‐induced longevity in C. elegans, neuronal BLI‐4 processes neuropeptides, which are then released with the assistance of UNC‐31 and GOLG‐2. ABSTRACT Dietary restriction (DR) is a well‐established method for extending lifespan across various species, including C. elegans.
Ping Wu, Lieselot Vandemeulebroucke, Huaihan Cai, Bart P. Braeckman   +3 more
wiley   +1 more source

From gonadotropin-inhibitory hormone to SIFamides: Are echinoderm SALMFamides the "missing link" in a bilaterian family of neuropeptides that regulate reproductive processes? [PDF]

, 2013
Bentley, Bonini, Broeck, Dockray, Díaz-Miranda, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Elshourbagy, Gouarderes, Hartenstein, Hewes, Hinuma, Janssen, Jekely, Jorgensen, Krishnan, Li, Liu, Maurice R. Elphick, Melarange, Melarange, Mirabeau, Mita, Mita, Mollereau, Newman, Newman, Perry, Putnam, Rowe, Satake, Terhzaz, Tsutsui, Ubuka, Ubuka, Van Kesteren, Veenstra, Veenstra, Vilim, Yang, Yasuda, Zhang   +46 more
core   +1 more source

Accumulation of GSK‐3β in Interneurons Impairs Adult Hippocampal Neurogenesis by Inhibiting GABAergic Transmission

Aging Cell, EarlyView.
Overexpression of GSK‐3β in DG GABAergic neurons impairs neurogenesis by reducing GABA release, which can be reversed by enhancing GABAergic transmission. ABSTRACT The activation of glycogen synthase kinase 3β (GSK‐3β) and the deterioration of spatial memory represent prominent pathological and clinical manifestations of Alzheimer's disease (AD ...
Fei Liu, Jiu‐Jing Cui, Xiao‐Lin Li, Zeng‐Min Zhang, Shao‐Hua Liang, Yi Sun, Jing‐Min Li, Hong‐Lin Qu, Jing Ye, Qi‐Peng Guo, Quan Zheng, Yong‐Feng Liu   +11 more
wiley   +1 more source

Mechanisms of alcohol influence on fear conditioning: A computational model

Alcohol, Clinical and Experimental Research, EarlyView.
Computational models can test mechanistic relationships between fear conditioning, neuroadaptations, and alcohol. Simulated fear extinction is slower and less robust under alcohol, as greater basolateral amygdala activation is needed. Alcohol shifts the amygdala network away from robust extinction by inhibiting central amygdala activity.
Adam Lonnberg, Marian L. Logrip, Alexey Kuznetsov   +2 more
wiley   +1 more source