Results 81 to 90 of about 21,072,923 (152)

Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonists

, 1994
Since the discovery of neuropeptide Y which is co-stored and co-operate with noradrenaline (NA) in sympathetic nerve fibers, several scientific groups have searched for structures with neuropeptide Y antagonistic properties.
Edvinsson, Lars, Hedner, T, David Erlinge, Erlinge, David, Sun, X Y, Lars Edvinsson, Xiang Ying Sun, Thomas Hedner   +7 more
core   +1 more source

Neuropeptide Y neurons mediate opioid-induced itch by disinhibiting GRP-GRPR microcircuits in the spinal cord

Nature Communications
Itch is a common side effect of opioid analgesics. The specific neurons mediating opioid-induced itch are still debated, and the mechanistic neuronal circuits remain elusive.
Qian Zeng, Yitong Li, Yifei Wu, Jiawei Wu, Kangtai Xu, Yiming Chen, Yunfei Rao, Nan Li, Yuhui Luo, Changyu Jiang, Chaoran Wu, Zilong Wang   +11 more
doaj   +1 more source

Targeting NPY5R—A Member of the NPY Receptor Family: Pharmacological and Transcriptomic Mechanisms of the Euphorbia Factor L2 Against Lung Adenocarcinoma

Pharmaceuticals
Background: Advanced lung adenocarcinoma (LUAD) is the leading cause of cancer-related deaths, with existing treatments hampered by drug resistance. This underscores the urgent need to identify novel therapeutic targets.
Pengzhuo Tao, Wei Liu, Yongfu Wang, Yajing Xue, Changmin Liu, Yizhen Yuan, Kim Fey Leu, Shilin Chen, Chi Song   +8 more
doaj   +1 more source

Energy homeostasis : crosstalk between adipose tissue and the human hypothalamus [PDF]

There is a worldwide epidemic of obesity. Weight rise is a consequence of continuous positive energy balance which leads to accumulation of body fat. Recent insights into adipose tissue (AT) biology have led to the conclusion that the adipocyte is not
Kos, Katarina
core  

Nociceptin/orphanin FQ and motor activity: behavioural, biochemical and electrophysiological studies in models of Parkinson’s disease [PDF]

, 2010
Nociceptin/orphanin FQ (N/OFQ) is an opioid-like neuropeptide which activates the NOP receptor. N/OFQ exerts an inhibitory control on locomotion through inhibition of dopamine (DA) neurons located in the substantia nigra (SN), which degenerate in ...
Viaro, Riccardo
core  

Cytoskeletal inhibitors impair Ca2+ elevations via neuropeptide Y and other Gi-coupled receptors

, 1996
Neuropeptide Y, alpha 2-adrenoceptors, thrombin and certain muscarinic acetylcholine receptors can couple to elevations of intracellular free Ca2+ concentrations via Gi-proteins.
Kaldenberg-Stasch, S., Wieland, T., Michel, M. C., Thomas Wieland, Martin C. Michel, Sylvia Kaldenberg-Stasch   +5 more
core   +1 more source

Characterization and deorphanization of RYamide signaling in Aedes aegypti: A potential regulator of hindgut-associated physiology.

PLoS ONE
Neuropeptide Y-related signaling, consisting of various neuropeptides and their receptors including, for example, the mammalian neuropeptide Y (NPY), pancreatic polypeptide (PP), and peptide YY (PYY) families, along with neuropeptide Y-like peptides in ...
Jinghan Tan, Thomas Luong, Jean-Paul V Paluzzi   +2 more
doaj   +1 more source

Corazonin Stimulates Ecdysteroid Synthesis during the Molting Process of the Swimming Crab, Portunus trituberculatus

Biology
The neuropeptide corazonin (Crz) exerts diverse physiological effects in insects, yet its role in crustaceans remains elusive. The abundant expression of Crz receptor (CrzR) in the Y-organs of several crustaceans suggests a potential involvement of Crz ...
Xi Xie, Jun Zhang, Shisheng Tu, Qi Zhou, Dongfa Zhu   +4 more
doaj   +1 more source

Techniques in Neuropeptide Processing, Trafficking, and Secretion

, 2007
Neuropeptides function as neurotransmitters and neuromodulators. They are synthesized as larger precursors at the rough endoplasmic reticulum (RER), trafficked to the trans-Golgi network (TGN), and sorted into granules of the regulated secretory pathway (
Nimesh Patel, Lou, Hong, Loh, Y Peng, Cawley, Niamh X, Niamh X. Cawley, Tulin Yanik, Hong Lou, Yanık, Tülin, Irina Arnaoutova, Y. Peng Loh, Arnatuova, Irina, Patel, Nimesh   +11 more
core   +1 more source

Is PP56 (D-myo-inositol-1,2,6-trisphosphate) an antagonist at neuropeptide Y receptors?

, 1993
PP56 (D-myo-inositol-1,2,6,-trisphosphate) has been reported to specifically inhibit neuropeptide Y-mediated effects in vasculature, heart and brain; because of its reversible but non-competitive antagonism interaction with neuropeptide Y receptor ...
Rascher, W., Michel, M. C., Feth, F., Erdbrügger, W.   +3 more
core   +1 more source