Results 111 to 120 of about 60,310 (240)

Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early‐life adversity

Alcohol, Clinical and Experimental Research, EarlyView.
Prenatal alcohol exposure (PAE) and early‐life adversity (ELA) independently and interactively disrupted neural activity within the social behavior network in adolescent rats, with age‐ and sex‐specific effects. PAE primarily dampened amygdala activity, while ELA altered medial prefrontal cortex responses. These findings reveal how different early‐life
Parker J. Holman, Linda Ellis, Amanda Chao, Cecilia Mitchell, Charlis Raineki, Joanne Weinberg   +5 more
wiley   +1 more source

Human Pulmonary Neuroendocrine Cells Respond to House Dust Mite Extract With PAR‐1 Dependent Release of CGRP

Allergy, Volume 80, Issue 4, Page 976-985, April 2025.
This study aimed to develop and characterize an in vitro human PNEC model and investigated the neuroendocrine response to HDM extract. Exposure to HDM leads to dose‐dependent induction of the CGRP encoding gene, CALCB, and corresponding release of the neuropeptide.
Ritu Mann‐Nüttel, Shivani Mandal, Marie Armbruster, Lakshmi Puttagunta, Paul Forsythe   +4 more
wiley   +1 more source

The Direct and Indirect Role of IgE on Airway Epithelium in Asthma

Allergy, Volume 80, Issue 4, Page 919-931, April 2025.
ABSTRACT Asthma is a chronic airway inflammatory disorder, affecting over 350 million people worldwide, with allergic asthma being the most common form of the disease. Allergic asthma is characterized by a type 2 (T2) inflammatory response triggered by numerous allergens beginning in the airway epithelium, which acts as a physical barrier to allergens ...
Christian Domingo, William W. Busse, Nicola A. Hanania, Muyesser Ertugrul, Lauren A. Millette, Tina Maio‐Twofoot, Xavier Jaumont, Oscar Palomares   +7 more
wiley   +1 more source

Effects of glucagon‐like peptide 1 receptor agonists on testicular dysfunction: A systematic review and meta‐analysis

Andrology, EarlyView.
Abstract Background Hypogonadism and infertility are two conditions that are heavily affected by overweight and obesity in the male patient. Glucagon‐like peptide 1 agonists (GLP‐1RAs) are a recently introduced class of antidiabetic drugs with powerful weight‐loss effect; this may induce an indirect positive effect on the testicular function ...
Gianmaria Salvio, Alessandro Ciarloni, Nicola Ambo, Monia Bordoni, Michele Perrone, Silvia Rossi, Giancarlo Balercia   +6 more
wiley   +1 more source

Misses and Near Misses in Paediatric Appendicitis: An Eight‐Year, Single‐Centre Retrospective Review

Acta Paediatrica, EarlyView.
ABSTRACT Aim Diagnostic error can result in the appendectomy of a normal appendix, commonly known as negative appendectomy (NA). Missed appendicitis (MA) is related to a poor outcome. The aim of this study was to determine whether there are factors in presentation associated with NA or MA.
Eric Scheier, Walid Abu Zvis, Sarah Borsekofsky   +2 more
wiley   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Central relaxin-3 administration causes hyperphagia in male Wistar rats. [PDF]

, 2005
B. M. C. McGowan, Bathgate, Bathgate, Bogatcheva, Burazin, Chen, Chen, E. L. Thompson, Fowler, Goto, Hsu, Hudson, Hudson, J. V. Gardiner, K. G. Murphy, K. L. Smith, Kamat, Kamegai, Kiwaki, Kong, Liu, Liu, M. A. Ghatei, M. M. Connolly, McKinley, N. E. White, S. A. Stanley, S. R. Bloom, Shintani, Sinnayah, Soloff, Stanley, Sudo, Thornton, Ward, Wren   +35 more
core   +1 more source

Characterisation of neurogenic lipolytic responses in white adipose tissue ex vivo

British Journal of Pharmacology, Volume 182, Issue 9, Page 1975-1988, May 2025.
Background and Purpose Dysfunction of the autonomic nervous system is associated with cardiovascular dysfunction, including metabolic syndrome and obesity. Understanding mechanisms of neurogenic control of white adipose tissue is key to understanding adipose physiology and pathophysiology, though there is limited research exploring this in adipose ...
Kayleigh E. Goddard, Samuel J. Fountain
wiley   +1 more source

Cannabidiol dose dependently reduces alcohol intake in mice via a non‐5‐HT1A receptor mechanism: Exploration of other potential receptor targets

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Binge drinking is a risky pattern of alcohol intake and a major predictor of alcohol use disorder (AUD). Current AUD medications have limited efficacy and poor patient compliance, calling for more effective therapeutics.
Connie J. Badolato, Erin A. Lynch, Jonathon C. Arnold, Iain S. McGregor, Michael T. Bowen   +4 more
wiley   +1 more source