Results 281 to 290 of about 197,147 (332)

Neuropeptide Y receptor antagonists in obesity

Expert Opinion on Investigational Drugs, 1997
Neuropeptide Y (NPY) is a 36 amino acid amidated peptide with high sequence homology to the endocrine peptides, peptide YY (PYY) and pancreatic polypeptide (PP). They appear to interact with a family of receptors that possess high affinity for one or more of these peptides.
D R, Gehlert, P A, Hipskind
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Neuropeptide Y receptors

2002
Abstract Neuropeptide Y (NPY) was isolated from porcine brain almost two decades ago (Tatemoto and Mutt 1980). This 36 amino acid residues shares high sequence homology and structural identity with two other peptides, namely peptide YY (PYY) and pancreatic polypeptide (PP) (Tatemoto et al . 1982).
Yvan Dumont, John Paul Redrobe, Rémi Quirion   +2 more
openaire   +1 more source

Neuropeptide Y potentiates noradrenaline-induced contraction through the neuropeptide Y Y1 receptor

European Journal of Pharmacology, 1996
To elucidate which neuropeptide Y receptor subtype is responsible for the neuropeptide Y-induced potentiation of the noradrenaline-evoked contraction in human omental arteries we used antisense oligodeoxynucleotide (Antisense), the new selective neuropeptide Y Y1 receptor antagonist, BIBP3226 {(R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl) methyl]-D ...
A, Bergdahl, T, Nilsson, L, Cantera, L, Nilsson, X Y, Sun, T, Hedner, D, Erlinge, S, Valdemarson, L, Edvinsson   +8 more
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Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y

International Endodontic Journal, 2010
Killough SA, Lundy FT, Irwin CR. Dental pulp fibroblasts express neuropeptide Y Y1 receptor but not neuropeptide Y. International Endodontic Journal, 43, 835–842, 2010.AbstractAim  To investigate whether dental pulp fibroblasts express neuropeptide Y (NPY) and NPY‐Y1 in vitro and to determine the effects of the cytokines including interlukin‐1β (IL‐1β)
Killough, S. A., Lundy, F. T., Irwin, C. R.   +2 more
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Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues

Peptides, 2002
mRNA encoding the human NPY Y1 and NPY Y2 receptors were detected in cerebral, meningeal, and coronary arteries using reverse transcriptase-polymerase chain reaction (RT-PCR). In addition, the trigeminal and superior cervical ganglia were positive for both receptors.
Rolf, Uddman, Sebastian, Möller, Torun, Nilsson, Susanne, Nyström, Jonas, Ekstrand, Lars, Edvinsson   +5 more
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Intracellular Trafficking of Neuropeptide Y Receptors

2015
The multireceptor multiligand system of neuropeptide Y receptors and their ligands is involved in the regulation of a multitude of physiological and pathophysiological processes. Specific expression patterns, ligand-binding modes, and signaling properties contribute to the complex network regulating distinct cellular responses.
Karin, Mörl, Annette G, Beck-Sickinger
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Neuropeptide Y promotes hepatic apolipoprotein A1 synthesis and secretion through neuropeptide Y Y5 receptor

Peptides, 2022
Apolipoprotein A1 (ApoA1), a major component of high-density lipoprotein (HDL), is a protective factor against cardiovascular disease (CVD). A recent epidemiological study found an association between neuropeptide Y (NPY) gene polymorphism and serum HDL levels. However, the direct effect of NPY on ApoA1 expression remains unknown.
Bingyang, Liu, Fu, Chen
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Neuropeptide Y receptor antagonists

Expert Opinion on Therapeutic Patents, 1999
On the basis of pharmacological observations, neuropeptide Y (NPY) has been implicated to be involved in numerous physiological functions. Preliminary results suggest a wide therapeutic utility for NPY antagonists in disorders such as anxiety, appetite stimulation, obesity, alcohol intake, hypertension, and regulation of coronary tone. This review will
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Neuropeptide Y Y1 receptors in vascular pharmacology

European Journal of Pharmacology, 1998
The existence of neurogenic mediator candidates apart from noradrenaline and acetylcholine involved in the control of vascular tone has attracted enormous attention during the past few decades. One such mediator is neuropeptide Y (NPY), which is co-localized with noradrenaline in sympathetic perivascular nerves.
A, Franco-Cereceda, J, Liska
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Neuropeptide Y Receptor in Vascular Smooth Muscle

Journal of Neurochemistry, 1991
Abstract: 125I‐Bolton‐Hunter (125I‐BH) neuropeptide Y (NPY) was used to identify specific high‐affinity NPY binding sites in porcine aortic smooth muscle membrane fractions and to characterize the binding sites in comparison with those in porcine hippocampal membrane fractions.
Y, Shigeri, S, Mihara, M, Fujimoto
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