Results 41 to 50 of about 27,803 (242)

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

Advanced Science, EarlyView.
This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker   +17 more
wiley   +1 more source

Combined gene overexpression of neuropeptide Y and its receptor Y5 in the hippocampus suppresses seizures

Neurobiology of Disease, 2012
We recently demonstrated that recombinant adeno-associated viral vector-induced hippocampal overexpression of neuropeptide Y receptor, Y2, exerts a seizure-suppressant effect in kindling and kainate-induced models of epilepsy in rats.
Casper R. Gøtzsche, Litsa Nikitidou, Andreas T. Sørensen, Mikkel V. Olesen, Gunnar Sørensen, Søren H.O. Christiansen, Mikael Ängehagen, David P.D. Woldbye, Merab Kokaia   +8 more
doaj  

Neuropeptide Y receptors in a protozoaStylonychia mytilus

Chinese Science Bulletin, 1998
Radio ligand binding assays(RLBA) were used to study neuropeptide Y (NPY) receptors in a protozoaStylonychia mytilus. The experimental results showed that 2–3 × 103/mLStylonychia cells incubated in Pringsheim solution which contained3H-NPY could specifically bind3H-NPY and concoraitantly present saturable characteristic.
Xiaoyun Zhang, Xiaoyang He, Yunhong Zhen
openaire   +2 more sources

CGRP‐Loaded ROS‐Responsive Hydrogel Restores Neuro‐Angiogenic Signaling to Promote Bone Regeneration in Diabetes‐Associated Periodontitis

Advanced Science, EarlyView.
This study shows that diabetes damages sensory nerve fibers, especially CGRP‐positive ones, in the periodontium and disrupts autophagy in trigeminal ganglion neurons, affecting bone homeostasis by inhibiting type H vessel formation. To address this, CGRP@PVA/tsPBA hydrogels are developed to release CGRP in response to ROS, which binds to endothelial ...
Chaoning Zhan, Qingyi Dai, Jianhan Ren, Lijian Jin, Weiping Wang, Zhou Ye, James Kit Hon Tsoi, Yifan Lin   +7 more
wiley   +1 more source

Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system

Cell Communication and Signaling, 2019
Background The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular studies in a physiological context.
Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Anette Kaiser, Simone Prömel   +3 more
doaj   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

The Multifaceted Etiology of Mental Disorders With a Focus on Trace Elements, a Review of Recent Literature

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Mental disorders are a significant global public health concern, affecting nearly one in eight individuals worldwide. This review investigates the multifaceted etiology of mental disorders—specifically major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BD)—through genetic, neurobiological, and environmental ...
Maria Francesca Astorino, Marco Calabrò, Carmenrita Infortuna, Maria Rosaria Anna Muscatello, Silvana Briuglia, Nicola Cicero, Chiara Fabbri, Alessandro Serretti, Concetta Crisafulli   +8 more
wiley   +1 more source

High-affinity neuropeptide Y receptor antagonists. [PDF]

Proceedings of the National Academy of Sciences, 1995
Neuropeptide Y (NPY) is one of the most abundant peptide transmitters in the mammalian brain. In the periphery it is costored and coreleased with norepinephrine from sympathetic nerve terminals. However, the physiological functions of this peptide remain unclear because of the absence of specific high-affinity receptor antagonists.
Johann Leban, R J Slepetis, Marilyn Jansen, Dennis Heyer, Andrew Spaltenstein, O H Viveros, A Tadepalli, Antonio Landavazo, Alejandro J. Daniels, W Harrington, J E Matthews   +10 more
openaire   +3 more sources

3‐Year Outcomes of Temperature‐Controlled Radiofrequency Ablation of the Posterior Nasal Nerve in Patients With Chronic Rhinitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Temperature‐controlled radiofrequency (TCRF) ablation of the posterior nasal nerve has been shown to improve chronic rhinitis (CR) symptoms and quality of life (QoL). This study assesses the durability of TCRF's effectiveness and safety 3 years post‐procedure in patients with perennial allergic CR and nonallergic CR.
J. Pablo Stolovitzky, Randall A. Ow, Stacey L. Silvers, Bobby A. Tajudeen, Chad M. McDuffie, Marc Dean, Ahmad R. Sedaghat, Katie Phillips, Masayoshi Takashima   +8 more
wiley   +1 more source

Factors associated with the development of dynapenia in patients with ulcerative colitis

Бюллетень сибирской медицины
Aim. To evaluate the association of insulin resistance and secretion of neuropeptide Y with dynapenia in patients with ulcerative colitis (UC). Materials and methods.
G. R. Bikbavova, M. A. Livzan, N. S. Lisyutenko, A. E. Romanyuk, A. A. Bondarenko   +4 more
doaj   +1 more source