Results 51 to 60 of about 21,072,923 (152)

Pharmacological and functional similarities of the human neuropeptide Y system in C. elegans challenges phylogenetic views on the FLP/NPR system

Cell Communication and Signaling, 2019
Background The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular studies in a physiological context.
Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Anette Kaiser, Simone Prömel   +3 more
doaj   +1 more source

Neuropeptide Y receptors in GtoPdb v.2025.3 [PDF]

Neuropeptide Y (NPY) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Neuropeptide Y Receptors [159]) are activated by the endogenous peptides neuropeptide Y, neuropeptide Y-(3-36), peptide YY, PYY-(3-36) and pancreatic polypeptide (PP).
Cox, Helen M., Schwartz, Thue, Quirion, Remi, Doods, Henri N., Beck-Sickinger, Annette G., Colmers, William F., Herzog, Herbert, Michel, Martin C., Larhammar, Dan, Westfall, Thomas   +9 more
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Neuropeptide Y modulates steroid production of human adrenal H295R cells through Y1 receptors [PDF]

, 2010
Neuropeptide Y (NPY) is abundantly expressed in the nervous system and acts on target cells through NPY receptors. The human adrenal cortex and adrenal tumors express NPY receptor subtype Y1, but its function is unknown. We studied Y1-mediated signaling,
Reubi, J.C., Flück, Christa E., Hofer, Gaby, Kempná, Petra, Nuoffer, Jean-Marc, Waser, Beatrice, Körner, Meike   +6 more
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Neuropeptides as regulators of bone metabolism: from molecular mechanisms to traditional Chinese medicine intervention strategies

Frontiers in Pharmacology
Osteoporosis (OP) is a complex bone metabolism disorder disease that affects the skeleton, nervous system, muscles, and multiple tissues. Neuropeptides, which are endogenous substances derived from both bone and brain, play a critical role in maintaining
Qing Lin, Qing Lin, Biyi Zhao, Jiajia Huang, Rumeng Chen, Weipeng Sun, Qianyun Ye, Qianyun Ye, Li Yang, Li Yang, Xiaofeng Zhu, Xiaofeng Zhu, Xiaofeng Zhu, Xiaoyun Li, Xiaoyun Li, Ronghua Zhang, Ronghua Zhang   +16 more
doaj   +1 more source

Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus

Neurobiology of Disease, 2007
We have shown that neuropeptide Y (NPY) regulates neurogenesis in the normal dentate gyrus (DG) via Y1 receptors (Howell, O.W., Scharfman, H.E., Herzog, H., Sundstrom, L.E., Beck-Sickinger, A. and Gray, W.P.
Owain W. Howell, Sharmalene Silva, Helen E. Scharfman, Alexander A. Sosunov, Malik Zaben, Anan Shatya, Guy Mckhann, II, Herbert Herzog, Alexandra Laskowski, William P. Gray   +9 more
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Envolvimento do neuropeptídeo Y na resiliência ao medo condicionado contextual em ratos [PDF]

, 2013
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2013.O neuropeptídeo Y (NPY) é o peptídeo mais abundante no sistema nervoso central (SNC), sendo ...
Lach, Gilliard
core  

Cell-Free Expression and Photo-Crosslinking of the Human Neuropeptide Y2 Receptor

Frontiers in Pharmacology, 2019
G protein-coupled receptors (GPCRs) represent a large family of different proteins, which are involved in physiological processes throughout the entire body. Furthermore, they represent important drug targets. For rational drug design, it is important to
Lisa Maria Kögler, Jan Stichel, Anette Kaiser, Annette G. Beck-Sickinger   +3 more
doaj   +1 more source

Neuropeptide y in sympathetic nerves — evidence for Y1 receptor mediated vascular control

, 1997
This chapter discusses the role of neuropeptide Y (NPY) in sympathetic neurotransmission and cardiovascular disorders. The release of transmitters—adenosine triphosphate (ATP), noradrenaline (NA), NPY—from sympathetic nerves is influenced by ...
Lundberg, JM, Rickard E. Malmström, Jan M. Lundberg, Malmström, RE   +3 more
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Characterization of Neuropeptide S (NPS) in view of its potential as a novel anxiolytic therapy for anxiety disorders [PDF]

, 2012
Anxiety disorders, such as posttraumatic stress disorder (PTSD), are characterized by a high prevalence and debilitating symptoms. However, the current first-line treatment for these conditions, which consists of selective serotonin reuptake inhibitors ...
Ionescu, Irina
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NPY2R signaling gates spontaneous and mechanical, but not thermal, pain transmission

Molecular Pain, 2019
Neuropeptide Y signaling plays an important role in inhibiting chronic pain in the spinal cord of mice. However, little is known about the respective roles of two major neuropeptide Y receptors, Y1R and Y2R, in evoked and spontaneous pain behavior under ...
Sihan Chen, Xian-Yu Liu, Yingfu Jiao, Zhou-Feng Chen, Weifeng Yu   +4 more
doaj   +1 more source