Cell-Free Expression and Photo-Crosslinking of the Human Neuropeptide Y2 Receptor
G protein-coupled receptors (GPCRs) represent a large family of different proteins, which are involved in physiological processes throughout the entire body. Furthermore, they represent important drug targets. For rational drug design, it is important to
Lisa Maria Kögler+3 more
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μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim+6 more
wiley +1 more source
Neuropeptide Y and Y1 Receptors in Kindling Epileptogenesis [PDF]
Neuropeptide Y (NPY)-mediated neurotransmission undergoes plastic changes during hippocampal or amygdaloid kindling in rats as shown by changes in peptide cellular expression and distribution, its release and receptor subtype plasticity (for review see 37, 51). Electrophysiological and pharmacological evidence in in vitro and in vivo models of seizures
openaire +3 more sources
Chicken neuropeptide Y-family receptor Y4: a receptor with equal affinity for pancreatic polypeptide, neuropeptide Y and peptide YY [PDF]
Within the neuropeptide Y (NPY) family of peptides, pancreatic polypeptide is the most divergent across species. It differs in 20 of 36 positions between human and chicken. In mammals, it binds primarily to the Y4 receptor, to which NPY and peptide YY (PYY) bind with lower affinities.
Ingrid Lundell+2 more
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Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke+36 more
wiley +1 more source
Y1 and Y5 receptors are both required for the regulation of food intake and energy homeostasis in mice. [PDF]
Neuropeptide Y (NPY) acting in the hypothalamus is one of the most powerful orexigenic agents known. Of the five known Y receptors, hypothalamic Y1 and Y5 have been most strongly implicated in mediating hyperphagic effects.
Amy D Nguyen+11 more
doaj +1 more source
Targeting Neuropeptide Receptors for Cancer Imaging and Therapy: Perspectives with Bombesin, Neurotensin, and Neuropeptide-Y Receptors [PDF]
Receptors for some regulatory peptides are highly expressed in tumors. Selective radiolabeled peptides can bind with high affinity and specificity to these receptors and exhibit favorable pharmacologic and pharmacokinetic properties, making them suitable agents for imaging or targeted therapy.
Philippe Fernandez+6 more
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Objective Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.
Kunihiro Otsuka+8 more
wiley +1 more source
The Role of Neuropeptide Y in Cardiovascular Health and Disease
Neuropeptide Y (NPY) is an abundant sympathetic co-transmitter, widely found in the central and peripheral nervous systems and with diverse roles in multiple physiological processes.
Cheryl M. J. Tan+5 more
doaj +1 more source
Deciphering the skeletal interoceptive circuitry to control bone homeostasis
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu+7 more
wiley +1 more source