Results 21 to 30 of about 296,111 (290)
Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane
Nature Communications, 2023 GABAB receptors mediate the effects of the main inhibitory neurotransmitter in the brain. Here, authors identify the cytoskeletal protein filamin A as a key player that controls the exact location and function of GABAB receptors at the cell surface.
Marie-Lise Jobin +12 more
doaj +1 more source
Interactions between the Nicotinic and Endocannabinoid Receptors at the Plasma Membrane
Membranes, 2022 Compartmentalization, together with transbilayer and lateral asymmetries, provide the structural foundation for functional specializations at the cell surface, including the active role of the lipid microenvironment in the modulation of membrane-bound ...
Ana Sofía Vallés +1 more
doaj +1 more source
The evolution and comparative neurobiology of endocannabinoid signalling [PDF]
, 2012 CB(1)- and CB(2)-type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol ...
Devane W. A. +4 more
core +1 more source
Illumination of a progressive allosteric mechanism mediating the glycine receptor activation
Nature Communications, 2023 Glycine receptors are channel receptors mediating signal transduction between neurons that transit between resting and open states upon neurotransmitter binding.
Sophie Shi +8 more
doaj +1 more source
Palmitoylation as a Functional Regulator of Neurotransmitter Receptors
Neural Plasticity, 2018 The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions.
Vladimir S. Naumenko, Evgeni Ponimaskin
doaj +1 more source
eLife, 2020 Neurotransmitter receptors and ion channels shape the biophysical properties of neurons, from the sign of the response mediated by neurotransmitter receptors to the dynamics shaped by voltage-gated ion channels.
Sandra Fendl +2 more
doaj +1 more source
Induction of synapse formation by de novo neurotransmitter synthesis
Nature Communications, 2022 Neuronal communication relies on matching different neurostransmitter types with their appropriate receptors. The authors here demonstrate that release of a novel neurotransmitter from presynaptic terminals can induce both the accumulation and activation
Scott R. Burlingham +10 more
doaj +1 more source
Acid-sensing ion channels 1a (ASIC1a) inhibit neuromuscular transmission in female mice [PDF]
, 2014 Acid-sensing ion channels (ASIC) open in response to extracellular acidosis. ASIC1a, a particular subtype of these channels, has been described to have a postsynaptic distribution in the brain, being involved not only in ischemia and epilepsy, but also ...
Colettis, Natalia Claudia +8 more
core +1 more source
Mechanism of Allosteric Modulation of the Cys-loop Receptors
Pharmaceuticals, 2010 The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function.
Paul Whiteaker +2 more
doaj +1 more source
Mechanism for neurotransmitter-receptor matching [PDF]
Proceedings of the National Academy of Sciences, 2020 SignificanceNeurotransmitter switching generally involves replacement of an excitatory transmitter with an inhibitory transmitter or vice versa and has been linked to changes in animal behavior. There are corresponding switches in postsynaptic receptors that enable continued function of the circuit, but the mechanism by which receptor expression is ...
Dena R. Hammond-Weinberger +3 more
openaire +4 more sources