Results 31 to 40 of about 214,427 (207)

Total ganglioside ablation at mouse motor nerve terminals alters neurotransmitter release level [PDF]

, 2010
Neuronal membrane gangliosides, forming a large family of sialylated glycosphingolipids, have been hypothesized to play important roles in synaptic transmission.
Furukawa, K., Plomp, J.J., Todorov, B., Willison, H.J., Zitman, F.M.P.   +4 more
core   +1 more source

Competition for synaptic building blocks shapes synaptic plasticity

eLife, 2018
Changes in the efficacies of synapses are thought to be the neurobiological basis of learning and memory. The efficacy of a synapse depends on its current number of neurotransmitter receptors. Recent experiments have shown that these receptors are highly
Jochen Triesch, Anh Duong Vo, Anne-Sophie Hafner   +2 more
doaj   +1 more source

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
core   +1 more source

Serotonin, how to find it... [PDF]

, 2013
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system (CNS) of animals, including humans ...
Crespi, Francesco
core   +1 more source

Two Players in the Field: Hierarchical Model of Interaction between the Dopamine and Acetylcholine Signaling Systems in the Striatum

Biomedicines, 2021
Tight interactions exist between dopamine and acetylcholine signaling in the striatum. Dopaminergic neurons express muscarinic and nicotinic receptors, and cholinergic interneurons express dopamine receptors.
Jaromir Myslivecek
doaj   +1 more source

Photo-antagonism of the GABAA receptor [PDF]

, 2014
Neurotransmitter receptor trafficking is fundamentally important for synaptic transmission and neural network activity. GABAA receptors and inhibitory synapses are vital components of brain function, yet much of our knowledge regarding receptor mobility ...
Topf, Maya, Hannan, S, Topf, M, Smart, T.G., Baker, JR, Iqbal, F, Iqbal, F., Baker, J.R., Hannan, S., Mortensen, M, Huckvale, R, Pandurangan, Arun, Pandurangan, AP, Huckvale, R., Mortensen, M., Smart, TG   +15 more
core   +1 more source

Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane

Nature Communications, 2023
GABAB receptors mediate the effects of the main inhibitory neurotransmitter in the brain. Here, authors identify the cytoskeletal protein filamin A as a key player that controls the exact location and function of GABAB receptors at the cell surface.
Marie-Lise Jobin, Sana Siddig, Zsombor Koszegi, Yann Lanoiselée, Vladimir Khayenko, Titiwat Sungkaworn, Christian Werner, Kerstin Seier, Christin Misigaiski, Giovanna Mantovani, Markus Sauer, Hans M. Maric, Davide Calebiro   +12 more
doaj   +1 more source

Interactions between the Nicotinic and Endocannabinoid Receptors at the Plasma Membrane

Membranes, 2022
Compartmentalization, together with transbilayer and lateral asymmetries, provide the structural foundation for functional specializations at the cell surface, including the active role of the lipid microenvironment in the modulation of membrane-bound ...
Ana Sofía Vallés, Francisco J. Barrantes   +1 more
doaj   +1 more source

Illumination of a progressive allosteric mechanism mediating the glycine receptor activation

Nature Communications, 2023
Glycine receptors are channel receptors mediating signal transduction between neurons that transit between resting and open states upon neurotransmitter binding.
Sophie Shi, Solène N. Lefebvre, Laurie Peverini, Adrien H. Cerdan, Paula Milán Rodríguez, Marc Gielen, Jean-Pierre Changeux, Marco Cecchini, Pierre-Jean Corringer   +8 more
doaj   +1 more source

Identification of a domain which affects kinetics and antagonistic potency of clozapine at 5-HT3 receptors. [PDF]

, 2009
The widely used atypical antipsychotic clozapine is a potent competitive antagonist at 5-HT(3) receptors which may contribute to its unique psychopharmacological profile. Clozapine binds to 5-HT(3) receptors of various species.
Gerhard Rammes, Caroline Nothdurfter, Tanasic, S., Rammes, G., Rupprecht, R., Eisensamer, Brigitte, Zieglgänsberger Walter, Christine Hosp, Tanasic, Sascha, Hosp Christine, Walter Zieglgänsberger, Rupprecht Rainer, Rammes, Gerhard, Sascha Tanasic, Hosp, C., Rammes Gerhard, Nothdurfter, C., Tanasic Sascha, Rupprecht, Rainer, Nothdurfter Caroline, Brigitte Eisensamer, Eisensamer, B., Zieglgänsberger, Walter, Zieglgänsberger, W., Hosp, Christine, Rainer Rupprecht, Nothdurfter, Caroline, Eisensamer Brigitte   +27 more
core   +1 more source