Results 21 to 30 of about 783,873 (297)

AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release

Frontiers in Molecular Neuroscience, 2023
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses.
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy   +9 more
doaj   +1 more source

Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission

Frontiers in Computational Neuroscience, 2022
Understanding synaptic transmission is of crucial importance in neuroscience. The spatial organization of receptors, vesicle release properties and neurotransmitter molecule diffusion can strongly influence features of synaptic currents. Newly discovered
Xiaoting Li, Xiaoting Li, Xiaoting Li, Gabriel Hémond, Antoine G. Godin, Antoine G. Godin, Nicolas Doyon, Nicolas Doyon   +7 more
doaj   +1 more source

Neurochemical Organization of the Drosophila Brain Visualized by Endogenously Tagged Neurotransmitter Receptors

Cell Reports, 2020
Summary: Neurotransmitters often have multiple receptors that induce distinct responses in receiving cells. Expression and localization of neurotransmitter receptors in individual neurons are therefore critical for understanding the operation of neural ...
Shu Kondo, Takahiro Takahashi, Nobuhiro Yamagata, Yasuhito Imanishi, Hidetaka Katow, Shun Hiramatsu, Katrina Lynn, Ayako Abe, Ajayrama Kumaraswamy, Hiromu Tanimoto   +9 more
doaj   +1 more source

Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales. [PDF]

, 2007
[spa] La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden
Carriba Domínguez, Paulina
core   +6 more sources

Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors

Pharmacological Research, 2023
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of ...
Federica Bono, Chiara Fiorentini, Veronica Mutti, Zaira Tomasoni, Giulia Sbrini, Hanna Trebesova, Mario Marchi, Massimo Grilli, Cristina Missale   +8 more
doaj   +1 more source

Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]

, 2003
The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Doepner, Richard F. G., Frungieri, Monica Beatriz, Kohn, Frank M., Doepner, R., Gamel-Didelon, Katia, Geigerseder, C., Mayerhofer, Artur, Thalhammer, A,, Geigerseder, Christof, Frungieri, Monica B., Köh, F. M., Calandra, Ricardo Saul, Calandra, Ricardo S., Gamel Didelon, K., Thalhammer, Andrea, Geigerseder, Christof;Doepner, Richard;Thalhammer, Andrea;Frungieri, Monica B.;Gamel-Didelon, Katia;Calandra, Ricardo S.;Köhn, Frank M.;Mayerhofer, Artur, Geigerseder, C;Doepner, R;Thalhammer, A;Frungieri, MB;Gamel-Didelon, K;Calandra, RS;Köhn, FM;Mayerhofer, A   +16 more
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Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
Beato, M., Marco Beato, Annalisa Scimemi, Scimemi, A.   +3 more
core   +1 more source

Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson’s disease

Communications Biology, 2021
Zarkali et al. identify two organizational gradients to structural-functional connectivity decoupling in Parkinson’s disease and relate spatial patterns of decoupling to the expression of neurotransmitter receptors.
Angeliki Zarkali, Peter McColgan, Louise-Ann Leyland, Andrew J. Lees, Geraint Rees, Rimona S. Weil   +5 more
doaj   +1 more source

Competition for synaptic building blocks shapes synaptic plasticity

eLife, 2018
Changes in the efficacies of synapses are thought to be the neurobiological basis of learning and memory. The efficacy of a synapse depends on its current number of neurotransmitter receptors. Recent experiments have shown that these receptors are highly
Jochen Triesch, Anh Duong Vo, Anne-Sophie Hafner   +2 more
doaj   +1 more source

Extrasynaptic glycine receptors of rodent dorsal raphe serotonergic neurons:a sensitive target for ethanol [PDF]

, 2014
Alcohol abuse is a significant medical and social problem. Several neurotransmitter systems are implicated in ethanol's actions, with certain receptors and ion channels emerging as putative targets.
Corteen, Nicole, Mitchell, Elizabeth A., Swinny, Jerome, Elizabeth A Mitchell, Lambert, Jeremy J., Jerome D Swinny, Scott J Greig, Edward P Maguire, Maguire, Edward P., Jeremy J Lambert, Nicole Corteen, Swinny, Jerome D., Delia Belelli, Greig, Scott J., David J K Balfour, Balfour, David J. K., Belelli, Delia   +16 more
core   +1 more source