Results 21 to 30 of about 205,018 (263)
AMPA and GABAA receptor nanodomains assemble in the absence of synaptic neurotransmitter release
Frontiers in Molecular Neuroscience, 2023 Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses.
Harrison J. Ramsay +9 more
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Computational modeling of trans-synaptic nanocolumns, a modulator of synaptic transmission
Frontiers in Computational Neuroscience, 2022 Understanding synaptic transmission is of crucial importance in neuroscience. The spatial organization of receptors, vesicle release properties and neurotransmitter molecule diffusion can strongly influence features of synaptic currents. Newly discovered
Xiaoting Li +7 more
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Cell Reports, 2020 Summary: Neurotransmitters often have multiple receptors that induce distinct responses in receiving cells. Expression and localization of neurotransmitter receptors in individual neurons are therefore critical for understanding the operation of neural ...
Shu Kondo +9 more
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Pharmacological Research, 2023 Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of ...
Federica Bono +8 more
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Communications Biology, 2021 Zarkali et al. identify two organizational gradients to structural-functional connectivity decoupling in Parkinson’s disease and relate spatial patterns of decoupling to the expression of neurotransmitter receptors.
Angeliki Zarkali +5 more
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Competition for synaptic building blocks shapes synaptic plasticity
eLife, 2018 Changes in the efficacies of synapses are thought to be the neurobiological basis of learning and memory. The efficacy of a synapse depends on its current number of neurotransmitter receptors. Recent experiments have shown that these receptors are highly
Jochen Triesch +2 more
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Biomedicines, 2021 Tight interactions exist between dopamine and acetylcholine signaling in the striatum. Dopaminergic neurons express muscarinic and nicotinic receptors, and cholinergic interneurons express dopamine receptors.
Jaromir Myslivecek
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Filamin A organizes γ‑aminobutyric acid type B receptors at the plasma membrane
Nature Communications, 2023 GABAB receptors mediate the effects of the main inhibitory neurotransmitter in the brain. Here, authors identify the cytoskeletal protein filamin A as a key player that controls the exact location and function of GABAB receptors at the cell surface.
Marie-Lise Jobin +12 more
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Interactions between the Nicotinic and Endocannabinoid Receptors at the Plasma Membrane
Membranes, 2022 Compartmentalization, together with transbilayer and lateral asymmetries, provide the structural foundation for functional specializations at the cell surface, including the active role of the lipid microenvironment in the modulation of membrane-bound ...
Ana Sofía Vallés +1 more
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Illumination of a progressive allosteric mechanism mediating the glycine receptor activation
Nature Communications, 2023 Glycine receptors are channel receptors mediating signal transduction between neurons that transit between resting and open states upon neurotransmitter binding.
Sophie Shi +8 more
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