Results 81 to 90 of about 115,139 (216)

Variability in intestinal drug metabolizing enzymes and transporters in Crohn's disease and potential impact on oral drug absorption

British Journal of Clinical Pharmacology, EarlyView.
Aims The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Sarah Alrubia, Brahim Achour, Zubida M. Al‐Majdoub, Amin Rostami‐Hodjegan, Jill Barber   +4 more
wiley   +1 more source

Cerebral Blood Flow Changes and Their Spatial Correlations With GABAa and Dopamine-D1 Receptor Explaining Individual Differences in Chronic Insomnia and the Therapeutic Effects of Acupuncture. [PDF]

Hum Brain Mapp
Yu L, Yang L, Xiaoqin C, Zheng X, Dou Z, Xiao X, Xia Z, Zhao G, He Y, Hu D, Zeng F, Yu S.   +11 more
europepmc   +1 more source

Trends in gabapentinoid prescribing: A nationwide Danish drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims Pregabalin and gabapentin are increasingly used for pain and other conditions. Concerns exist about overuse as well as potential misuse and abuse. To guide rational prescribing practices, we provide detailed nationwide data on the use of gabapentinoids in Denmark.
Anton Pottegård, Lotte Rasmussen, Morten Olesen, Anne Mette Skov Sørensen, Zandra Nymand Ennis, Joseph Kane, Sarah Baxter, Blánaid Hicks   +7 more
wiley   +1 more source

Molecular Anatomy of Synaptic and Extrasynaptic Neurotransmission Between Nociceptive Primary Afferents and Spinal Dorsal Horn Neurons. [PDF]

Int J Mol Sci
Antal M.
europepmc   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Neuroinflammation-A Crucial Factor in the Pathophysiology of Depression-A Comprehensive Review. [PDF]

Biomolecules
Sălcudean A, Bodo CR, Popovici RA, Cozma MM, Păcurar M, Crăciun RE, Crisan AI, Enatescu VR, Marinescu I, Cimpian DM, Nan AG, Sasu AB, Anculia RC, Strete EG.   +13 more
europepmc   +1 more source

Chemical Composition, Antioxidant, Antimicrobial, Antidiabetic, and Butyrylcholinesterase Inhibitory Activities in Vitro of the Essential Oil and Crude Extracts of the Aerial Parts of Thymus ciliatus

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study explores the potential of Thymus ciliatus as a natural source of bioactive compounds by investigating its chemical composition and in vitro biological activities, including antioxidant, antimicrobial, antidiabetic, and anti‐Alzheimer properties.
Nadia Djermane, Mostapha Brahmi, Djallal Eddine Adli, Micaela Gliozzi, Vincenzo Musolino, Rebbas Khellaf, Ramazan Erenler, Rabah Arhab, Stefania Garzoli   +8 more
wiley   +1 more source

Genetic and molecular basis of abnormal BOLD signaling variability in patients with major depressive disorder after electroconvulsive therapy. [PDF]

Transl Psychiatry
Fan S, Zhang Y, Qian R, Hu J, Zheng H, Dai W, Ji Y, Wu Y, Xie X, Xu S, Ji GJ, Tian Y, Wang K.   +12 more
europepmc   +1 more source

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

Chemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb, Morkoss Fakhry, Ali K. Albuhadily, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha   +5 more
wiley   +1 more source

Molecular organization of central cholinergic synapses. [PDF]

Proc Natl Acad Sci U S A
Rosenthal JS, Zhang D, Yin J, Long C, Yang G, Li Y, Lu Z, Li WP, Yu Z, Li J, Yuan Q.   +10 more
europepmc   +1 more source