Results 181 to 190 of about 91,475 (280)

Assessment of [¹²⁵I]a-Bungarotoxin Binding to a7 Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinson's Disease Brain. [PDF]

Biomolecules
Karim F, Ngo A, Tucker TE, Coronel ADL, Mukherjee J.   +4 more
europepmc   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

The Need for and Importance of Thorough and Comprehensive Studies on the Molecular Mechanisms of Action of Animal Toxins, Venoms, and Antivenoms. [PDF]

Int J Mol Sci
Kini RM, Utkin YN.
europepmc   +1 more source

Novel Drug Targets for Neurodegenerative Diseases of Elderly People to Develop Effective Therapeutics: A Comprehensive Analysis. [PDF]

Adv Pharmacol Pharm Sci
Biswas P, Rahman MH, Tabassum A, Shoyshob TZ, Jalouli M, Islam Tareq MM, Imtiaz M, Dona HA, Harrath AH, Rahman MA.   +9 more
europepmc   +1 more source

Heat‐Not‐Burn Tobacco Aerosols Induce Immune Dysregulation and Barrier Disruption Comparable to Conventional Cigarettes

Allergy, EarlyView.
Comparative analysis between cigarette smokers and HnB users revealed similar inflammatory lung function parameters and immunophenotypic patterns. Cigarette smoke and HnB aerosol had an impact on ECM through divergent downstream pathways. Exposed to Cigarette smoke and HnB aerosol caused comparative TJ weakening in the epithelial barrier.
Dilara Karaguzel, Alicja Walewska, Basak Ezgi Sarac, Marlena Tynecka, Kinga Bondarczuk, Agnieszka Tarasik, Dariusz Kisiel, Karolina Partyk, Damian Pogodziński, Bartosz Hanczaruk, Alicja Toczydlowska, Cagla Bicakci, Doga Oztabak, Magdalena Niemira, Adam Kretowski, Marlena Dubatowka, Natalia Ogrodnik, Malgorzata Chlabicz, Pawel Sowa, Karol Kaminski, Marcin Moniuszko, Andrzej Eljaszewicz, Cagatay Karaaslan   +22 more
wiley   +1 more source

Exposures in Indoor Air Affecting Health

Allergy, EarlyView.
ABSTRACT Indoor air quality (IAQ) is influenced by a wide range of chemical, biological and physical agents that can negatively impact physical, immunological and mental health. Adverse health effects depend on the type and concentration of pollutants, duration of exposure, and individual susceptibility.
Maria Hartiala, Varpu Elenius, Alicia Aguado Pesquera, Silas Androulakis, Isabella Annesi‐Maesano, Artur Badyda, Sicco Brandsma, Ioanna Chatziprodromidou, Goran Gajski, Judith Garcia‐Aymerich, Chiara Giorio, Timo Hugg, Jouni J. K. Jaakkola, Sarah Koch, Pim E. G. Leonards, Angeliki Matrali, Lisa Melymuk, Natalie Mueller, Adam Muszyński, Jet Opbroek, Inês Paciência, Spyros N. Pandis, Sofya Pozdniakova, Aino K. Rantala, Sandra Rodríguez Sufuentes, Linda Schenk, Eva Sugeng, Adrià Sunyer‐Caldú, Apostolos Vantarakis, Alexander Zherebker, Ernesto Alfaro‐Moreno, Pernilla Bohlin Nizzetto, José Fermoso Dominguez, Stylianos Karatzas, Francesco Mureddu, Heidi Salonen, Nikolaos Papadopoulos, Tuomas Jartti, the IDEAL Consortium   +38 more
wiley   +1 more source

Discovery and mechanism of negative allosteric modulation of the α7 nicotinic acetylcholine receptor by nanobodies. [PDF]

Proc Natl Acad Sci U S A
Barilone N, Vangelatou M, Marouf FZ, Dejean de la Bâtie G, Li Q, Lafaye P, Aymé G, Corringer PJ, Prevost MS.   +8 more
europepmc   +1 more source

Hemocompatibility and Long‐Term Outcomes in HeartWare Versus HeartMate II Versus HeartMate 3: Multicenter Real‐World Cohort

Artificial Organs, EarlyView.
Multicenter real‐world cohort (n = 327) comparing LVADs: HeartMate 3 (HM3), HeartMate II (HMII), and HeartWare (HVAD). HM3 showed superior long‐term survival versus legacy devices, driven by fewer hemocompatibility‐related adverse events, especially pump thrombosis and ischemic stroke, while major bleeding was similar across devices.
Hamza H. H. Ben Nasir, Ahmed F. A. Mohammed, Omar Allham, Alish Kolashov, Yusuf Shieba, Lachmandath Tewarie, Bernd Panholzer, Ajay Moza, Assad Haneya, Rashad Zayat   +9 more
wiley   +1 more source

P2X4 receptors as the dynamic regulators of auditory sensory cell activity: a potential new mechanism for protecting hearing? [PDF]

Purinergic Signal
Fisher-Ridoux A, Suzuki-Kerr H.
europepmc   +1 more source

Cholinergic system in schizophrenia: A systematic review and meta-analysis. [PDF]

Mol Psychiatry
Saint-Georges Z, MacDonald J, Al-Khalili R, Hamati R, Solmi M, Keshavan MS, Tuominen L, Guimond S.   +7 more
europepmc   +1 more source