Results 211 to 220 of about 91,154 (280)

Dual cholinergic and serotonergic excitatory pathways mediate oxygen sensing in the zebrafish gill. [PDF]

J Physiol
Reed M, Mavridis AA, Mennigen JA, Jonz MG.   +3 more
europepmc   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

The ATP-mediated cytokine release by macrophages is down-modulated by unconventional α9* nicotinic acetylcholine receptors. [PDF]

Front Immunol
Wolf PMK, Hanke D, Singh VK, Keller HL, Ettischer LJ, Teppe L, Amati AL, Hecker A, Husain-Syed F, Rohde M, Nuber UA, Büttner K, McIntosh JM, Liese J, Mazurek S, Grau V, Richter K.   +16 more
europepmc   +1 more source

Increased Cardiovascular Risk in Chronic Spontaneous Urticaria: A Large Real‐World Cohort Study

Allergy, EarlyView.
Philip Curman, Diamant Thaçi, Ralf J. Ludwig   +2 more
wiley   +1 more source

Profiling of HCAR1 signalling reveals Gαi/o and Gαs activation without β‐arrestin recruitment and the discovery of an allosteric agonist

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Lactate, historically viewed as a metabolic by‐product, has emerged as a signalling molecule via the G protein–coupled receptor Hydroxycarboxylic Acid Receptor 1 (HCAR1). The receptor is primarily expressed in adipocytes but also found in various other tissues.
Simon Lind, Shane C. Wright, Emilia Gvozdenovic, Kristina Nilsson, Kenneth L. Granberg, Michel Bouvier, Linda C. Johansson   +6 more
wiley   +1 more source

Integrative Neuroimmune Role of the Parasympathetic Nervous System, Vagus Nerve and Gut Microbiota in Stress Modulation: A Narrative Review. [PDF]

Int J Mol Sci
Kurhaluk N, Kołodziejska R, Kamiński P, Tkaczenko H.   +3 more
europepmc   +1 more source

Prenatal Diagnosis of MSL2‐Related Ventriculomegaly in Association With an Inherited 15q13 Microduplication

Clinical Genetics, EarlyView.
We hereby report the first prenatal diagnosis of MSL2‐related pathology, namely ventriculomegaly. Favorable 11‐month follow‐up illustrates the challenges in predicting postnatal outcomes for genetic anomalies linked to recently characterized phenotypes with limited documented cases.
Omar Zgheib, Thomas Rio Frio, Jean‐Marie Pellegrinelli, Stefania Gimelli, Caterina Marconi, Delphine Le Mercier, Monica Rebollo Polo, Céline Habre, Joël Fluss, Russia Ha‐Vinh Leuchter, Marc Abramowicz, Rosalinda Giannini, Siv Fokstuen   +12 more
wiley   +1 more source

Ca²⁺ influx through muscle-type nicotinic acetylcholine receptors in zebrafish contributes to contractions and development of slow muscle cells in early development. [PDF]

Open Biol
Zempo B, Ono F, Nakajo K.
europepmc   +1 more source

Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy

Developmental Medicine &Child Neurology, EarlyView.
Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman, Oscar Horwath, Eva Pontén, Sudarshan Dayanidhi, Ferdinand von Walden   +4 more
wiley   +1 more source

The dopamine paradox in glioblastoma oncology: methylxanthine therapy against nicotine-driven pathogenesis. [PDF]

Ann Med Surg (Lond)
Mursaleen M, Tahir M, Suleman MU, Tabassum SN, Khalil U.   +4 more
europepmc   +1 more source