Results 121 to 130 of about 33,193 (249)

The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist [PDF]

, 2020
The kappa opioid receptor (κOR) is an important target for pain therapeutics to reduce depression and other harmful side effects of existing medications.
Goddard, William A., III, Kim, Soo-Kyung, Mafi, Amirhossein   +2 more
core   +1 more source

Selective review and commentary on emerging pharmacotherapies for opioid addiction. [PDF]

, 2011
Pharmacotherapies for opioid addiction under active development in the US include lofexidine (primarily for managing withdrawal symptoms) and Probuphine®, a distinctive mode of delivering buprenorphine for six months, thus relieving patients, clinicians,
Ling, Walter, Miotto, Karen, Mooney, Larissa, Nielsen, Suzanne, Torrington, Matthew, Zhao, Min   +5 more
core   +2 more sources

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? – a systematic review

Journal of Child Psychology and Psychiatry, Volume 66, Issue 4, Page 516-546, April 2025.
Proliferation of the term “emotion dysregulation” in child psychopathology parallels the growing interest in processes that influence negative emotional reactivity. While it commonly refers to a clinical phenotype where intense anger leads to behavioral dyscontrol, the term implies etiology because anything that is dysregulated requires an impaired ...
Joseph C. Blader, Amy S. Garrett, Steven R. Pliszka   +2 more
wiley   +1 more source

Supporting Breastfeeding in the Setting of Perinatal Opioid Use Disorder

Journal of Midwifery &Women's Health, EarlyView.
Abstract Studies have shown that many pregnant women with opioid use disorder intend to initiate breastfeeding after giving birth. However, continuation rates beyond the initial postpartum hospitalization are low. Achieving and maintaining an antepartum breastfeeding plan may be complicated by the unique challenges that opioid‐exposed dyads experience ...
Lindsey A. Baksh, Stephanie M. Hartwig
wiley   +1 more source

Pathology and glia type specific changes of the DPP4 activity in the spinal cord contributes to the development and maintenance of hyperalgesia and shapes opioid signalling in chronic pain states [PDF]

, 2017
Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various chronic pain states, and remain difficult to treat.
Alpár, Alán, Balázsa, Tamás, Barta, Benjamin, Bölcskei, Kata, Fekete, Csaba, Gerber, Gábor, Helyes, Zsuzsanna, Király, Kornél, Kozsurek, Márk, Lukácsi, Erika, Pap, Károly, Puskár, Zita, Szabon, Judit, Tekus, Valeria, Tóth, Zsuzsanna   +14 more
core  

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Clinical utility of naloxegol in the treatment of opioid-induced constipation

Journal of Pain Research, 2015
Heather C Bruner,1 Rabia S Atayee,2 Kyle P Edmonds,3 Gary T Buckholz3 1Scripps Health and University of California San Diego, Joint Hospice and Palliative Medicine Fellowship, San Diego, CA, USA; 2University of California San Diego, Skaggs School of ...
Bruner HC, Atayee RS, Edmonds KP, Buckholz GT   +3 more
doaj  

Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study aimed to compare the pharmacokinetic profile of the active dipyrone metabolites 4‐methylaminoantipyrine (MAA) and 4‐aminoantipyrine (AA) administered alone and in combination with tramadol in dogs. Nine mixed‐breed dogs, weighing 15.33 ± 2.25 kg, participated in a two‐treatment crossover design: G1 received intravenous dipyrone (25 ...
Andressa Nunes Mouta, Kathryn Nóbrega Arcoverde, Robson dos Anjos Honorato, Naftáli Silva Fernandes, Caio Vinicius Almeida de Oliveira, Glícia Cavalcante Mesquita, Yanna Deysi Bandeira Passos, Gabriel Araújo‐Silva, Valéria Veras de Paula   +8 more
wiley   +1 more source

Pharmacokinetics of a Single Subcutaneous Extended‐Release Buprenorphine (Ethiqa XR) in Healthy Beagles

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study evaluated the pharmacokinetics of an extended‐release buprenorphine formulation (Ethiqa XR) in dogs and explored potential sex differences. Twelve healthy intact beagles (6 males and 6 females) received a single subcutaneous injection of Ethiqa XR (0.2 mg/kg).
Kornelia Tiffinger, Hiroko Enomoto, Ronald E. Baynes, Laura M. Neumann, B. Duncan X. Lascelles, Masataka Enomoto   +5 more
wiley   +1 more source