Results 131 to 140 of about 33,193 (249)
Retromer Opposes Opioid-Induced Downregulation of the Mu Opioid Receptor
Abstract The mu opioid receptor (MOR) is protected from opioid-induced trafficking to lysosomes and proteolytic downregulation by its ability to access the endosomal recycling pathway through its C-terminal recycling motif, LENL. MOR sorting towards the lysosome results in downregulation of opioid signaling while recycling of MOR to the
Aleksandra Dagunts +4 more
openaire +2 more sources
Effects of Electroacupuncture at ST36 on Visceral Pain and Inflammatory Markers in IBS Rats
Neurogastroenterology &Motility, EarlyView.Electroacupuncture (EA) at ST36 significantly reduced visceral pain and colonic inflammation in IBS model rats. EA increased pain thresholds, lowered AWR scores, and downregulated key inflammatory mediators (IL‐1β, IL‐6, TNF‐α, TRPV1, NF‐κB). These findings highlight ST36‐targeted EA as a promising therapeutic strategy for IBS visceral hypersensitivity
Ya‐bo Hao +6 more
wiley +1 more source
The Efficacy of Peripheral Opioid Antagonists in Opioid-Induced Constipation and Postoperative Ileus: A Systematic Review of the Literature. [PDF]
, 2017 Opioid-induced constipation has a negative impact on quality of life for patients with chronic pain and can affect more than a third of patients. A related but separate entity is postoperative ileus, which is an abnormal pattern of gastrointestinal ...
Baratta, Jaime L. +5 more
core +1 more source
Ligands for the sigma receptor and the mu-opioid receptor [PDF]
, 2018 The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.
openaire +2 more sources
Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1584-1596, June 2026.Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub +5 more
wiley +1 more source
Addiction, Volume 121, Issue 6, Page 1616-1621, June 2026.Abstract Revived interest in psychedelic‐assisted therapies has also renewed focus on ibogaine, a psychoactive alkaloid, for its notable anti‐addictive potential. Evidence from observational, open‐label, and limited randomized placebo‐controlled trials indicates that ibogaine and its metabolite noribogaine reduce craving and withdrawal symptoms in ...
Tibor Markus Brunt
wiley +1 more source
Addiction, Volume 121, Issue 6, Page 1541-1556, June 2026.Abstract Background and aims Recreational ketamine use has increased globally and is associated with psychiatric and cognitive concerns. The hippocampus in preclinical models shows damage and working‐memory disruption with repeated dosing. However, whether specific hippocampal subregions may differ in people with chronic ketamine use remains unclear ...
Yi‐Hsuan Liu +8 more
wiley +1 more source
Fentanyl Compromises Lower‐Airway Mechanics and Naloxone Triggers a Transient Mechanical Overshoot
Acta Physiologica, Volume 242, Issue 6, June 2026.ABSTRACT Aim Opioid‐induced respiratory depression (OIRD) is the leading cause of death following opioid overdose, due to its effects on central rhythm generation, and airway and thoracic constriction. While the effects on rhythm generation have been well documented, the effects of fentanyl on airway constriction are less well understood. We tested the
Riley R. Parks +4 more
wiley +1 more source
Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits
British Journal of Pharmacology, Volume 183, Issue 12, Page 3195-3212, June 2026.Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini +9 more
wiley +1 more source
Amniotic-Fluid Ingestion Enhances the Central\ud Analgesic Effect of Morphine [PDF]
, 1991 Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin ...
DiPirro, Jean M. +2 more
core