Results 141 to 150 of about 33,193 (249)

GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling

British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.
G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley   +1 more source

Genetic Architecture of Addiction‐Relevant Behaviors in Outbred Sprague–Dawley Rats Reveals Loci for Anxiety‐Like and Nociceptive Traits

Genes, Brain and Behavior, Volume 25, Issue 3, June 2026.
Genome‐wide association analyses in outbred Sprague–Dawleys identified loci for anxiety‐like and nociceptive behavior on chromosomes 1, 14, and 17, which are distinct from facets of exploratory locomotion significant in our GWAS of a F2 intercross of selectively bred high‐ and low‐responder (to a novel environment) Sprague–Dawleys.
Apurva S. Chitre, Elaine K. Hebda‐Bauer, Michael A. Emery, Fei Li, Khai‐Minh Nguyen, Yizhi Wang, Riyan Cheng, Oksana Polesskaya, Stanley J. Watson Jr, Jun Li, Huda Akil, Abraham A. Palmer   +11 more
wiley   +1 more source

Does Prolonged Naltrexone Therapy Alter the Rewarding Nature of Exercise, Socialization, and Eating? A Narrative Review

McGill Journal of Medicine
Introduction: Naltrexone is an opioid receptor antagonist prescribed for alcohol use disorder and opioid use disorder.  Naltrexone has a high affinity for the mu-opioid receptors, which are the primary binding site of beta-endorphin.
Caitlin Collier, Thomas Hilton
doaj   +1 more source

Factors associated with potentially inappropriate medication use, medication underuse and overuse in older adults in the German National Cohort

Journal of Internal Medicine, Volume 299, Issue 6, Page 754-775, June 2026.
Abstract Background Effectively identifying individuals exposed to drug underuse, overuse and potentially inappropriate medication (PIM) in older adults is essential for minimizing preventable drug‐related harms. Methods We analysed data from 54,296 individuals aged 60–74 years from the German National Cohort (NAKO).
Miriam Degen, Ulrike Haug, Oliver H. F. Scholle, Yaw Awuku‐Larbi, Sigrid Carlsson, Nina Ebert, Volker Harth, Anja M. Hauri, Margit Heier, Anne Herrmann, Michael Leitzmann, Jakob Linseisen, Claudia Meinke‐Franze, Nadia Obi, Phil Pendt, Thomas Reinhold, Barbara Thorand, Hermann Brenner, Ben Schöttker   +18 more
wiley   +1 more source

Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Opioid use disorder (OUD) may adversely affect brain health, but its role in dementia risk remains poorly understood. METHODS We investigated associations between OUD and dementia using observational data from 222,518 participants (European and African ancestry) in the Million Veteran Program and Mendelian randomization (MR) using
Sara Javidnia, James M. Roe, Ville Karhunen, Dipender Gill, Steven Bell, Joseph D. Deak, Daniel Levey, Rachel L. Kember, Henry R. Kranzler, Héléne Toinét Cronjé, Stephen Burgess, Joel Gelernter, Klaus P. Ebmeier, Anya Topiwala   +13 more
wiley   +1 more source

Opioid/Dopamine Receptor Binding Studies, NMR and Molecular Dynamics Simulation of LENART01 Chimera, an Opioid-Bombesin-like Peptide

Molecules
The design and development of hybrid compounds as a new class of drug candidates remains an excellent opportunity to improve the pharmacological properties of drugs (including enzymatic stability, efficacy and pharmacokinetic and pharmacodynamic profiles)
Pawel Serafin, Łukasz Szeleszczuk, Igor Zhukov, Edina Szűcs, Dávid Gombos, Azzurra Stefanucci, Adriano Mollica, Dariusz Maciej Pisklak, Patrycja Kleczkowska   +8 more
doaj   +1 more source

Correspondence of Basal Forebrain Resting‐State Functional Connectivity and Cerebral Glucose Metabolism Alterations With Neurotransmitter Maps in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Altered functional connectivity of basal forebrain subregions (Ch1‐3, Ch4) and widespread cerebral hypometabolism were identified in Alzheimer's disease using simultaneous PET/MRI. Spatial correspondence with normative neurotransmitter receptor and transporter maps suggested that serotonergic and dopaminergic systems may contribute to AD‐related ...
Yujie He, Hanxiao Xue, Sheng Bi, Yan Wang, Xiaocao Liu, Yixia Li, Zhigeng Chen, Dongdong Rong, Bixiao Cui, Jie Ma, Shaozhen Yan, Jie Lu   +11 more
wiley   +1 more source

The biopsychology of maternal behavior in nonhuman mammals [PDF]

, 1990
The term “maternal behavior,” when applied to nonhuman mammals, includes the behaviors exhibited in preparation for the arrival of newborn, in the care and protection of the newly arrived young, and in the weaning of those young, and represents a complex
Kristal, Dr. Mark B.
core  

Multiscale Cortical Remodeling Following Abrupt Visual Deafferentation in Rhegmatogenous Retinal Detachment: Imaging Transcriptomics and Neurotransmitter Mapping

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
RRD triggers multiscale cortical reorganization, including visual‐network atrophy, shortened intrinsic neural timescale, and altered structural covariance gradients. Integrating Mendelian randomization with AHBA and PET/SPECT biological anchoring and SHAP‐based classification highlights INT as a sensitive imaging biomarker for RRD‐related brain ...
Yu Ji, Xin Huang, Yuan‐Yuan Wang, Lin Zhou, Zhuo‐Er Dong, Xiao‐Rong Wu   +5 more
wiley   +1 more source

Behavioural Characterisation and Pharmacological Validation of an Incisional Wound‐Related Pain Model

European Journal of Pain, Volume 30, Issue 5, May 2026.
ABSTRACT Background Wound‐related pain represents a significant unmet clinical need. To advance its understanding and treatment, there is a need for a validated preclinical model for the study of wound‐related pain in both sexes. Methods A 1.2 cm incision was created on the hairy skin of the dorsum of male and female Sprague–Dawley rats posterior to L4.
Catherine R. Healy, Maria C. Redmond, Mary Hopkins, Georgina Gethin, Abhay Pandit, David P. Finn   +5 more
wiley   +1 more source