Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]
, 2007 Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
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Exploring the role of mu opioid receptor (OPRM1) and CYP2B6 gene variations for methadone pharmacogenomics. Can these variations be used to advance toxicological interpretation post-mortem?. [PDF]
Methadone is increasingly involved in drug overdose cases and the molecular actions of the drug in vivo are largely unknown requiring elucidation. This study set out to examine the relationship between methadone toxicity and CYP2B6 and mu (μ) opioid ...
Bunten, Hannah
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Determination of mitragynine bound opioid receptors [PDF]
, 2010 Mitragyna Speciosa Korth from Rubiaceae family is a tropical plant indigenous to Southeast Asia particularly in Thailand, Peninsular of Malaysia and Indonesia.
Adzhar, Muhammad Farhan +5 more
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Blockade of non-opioid excitatory effects of spinal Dynorphin A at bradykinin receptors [PDF]
, 2015 Dynorphin A (Dyn A) is an endogenous opioid peptide that produces neuroinhibitory (antinociceptive) effects via m, d, and k opioid receptors. However, under chronic pain conditions, up-regulated spinal Dyn A can also interact with bradykinin receptors ...
Yeon Sun Lee, Sara M Hall, Cyf Ramos-Colon, Michael Remesic, David Rankin, Todd W Vanderah, Frank Porreca, Josephine Lai, Victor J Hruby
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The opioid placebo analgesia is mediated exclusively through mu-opioid receptor in rat [PDF]
, 2013 Placebo analgesia is one of the most robust and best-studied placebo effects. Recent researches suggest that placebo analgesia activated the m-opioid receptor signalling in the human brain.
Zhang, Wen-Cai +3 more
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Selective targeting of mu opioid receptors to primary cilia
Cell ReportsSummary: Opioid receptors are therapeutically important G protein-coupled receptors (GPCRs) with diverse neuromodulatory effects. The functional consequences of opioid receptor activation are known to depend on receptor location in the plasma membrane ...
Rita R. Fagan +5 more
doaj +1 more source
Regulation of c-jun n-terminal kinases by opioid receptors [PDF]
, 2002 In mammals, the G protein-coupled opioid receptors are mainly expressed in the central nervous system, and early pharmacological studies on immunocytes indicate that the classical δ-, μ- and κ-opioid receptors are also present in platelets, lymphocytes ...
Kam, Yuet Fong
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Molecular Aspects of Opioid Receptors and Opioid Receptor Painkillers
, 2012 The unpleasant sensation of pain is experienced by all human beings at a given point in life. When pain gets severe and/or chronic it requires medical treatment. For over a thousand years, opioid agonists have been employed therapeutically to treat pain, with the first reports of such use involving the alkaloid morphine dated to the second century B.C.(
Austin B., Karina Martinez-Mayorg
openaire +2 more sources
Delta opioid receptor involvement in endocrine pathophysiology [PDF]
, 1992 A comprehensive review of delta-opioid receptors involvement in endocrine ...
MARGUTTI, Angelo +8 more
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Differential Pharmacological Actions of Methadone and Buprenorphine in Human Embryonic Kidney 293 Cells Coexpressing Human Mu-Opioid and Opioid Receptor-Like 1 Receptors [PDF]
, 2012 Methadone and buprenorphine are used in maintenance therapy for heroin addicts. In this study, we compared their effects on adenylate cyclase (AC ) activity in human embryonic kidney (HEK) 293 cells stably overexpressing human mu-opioid receptor (MOR ...
LEE, CYNTHIA WEI-SHENG;YAN, JIA-YING;CHIANG, YAO- CHANG;HUNG, TSAI-WEI;WANG, HUNG-LI;CHIOU, LIH- CHU;HO, ING-KANG +1 more
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