Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception [PDF]
, 2004 Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating ...
DiPirro, Jean M., Kristal, Dr. Mark B.
core
Interactions of GPR54 and GPR147 receptors with RF-amide ligands [PDF]
, 2014 Includes bibliographical references.G protein-coupled receptors play a key role in cellular signaling by transducing extracellular signals via G proteins to elicit intracellular responses.
Hendrikse, Megan
core
Leukocyte opioid receptors mediate analgesia via Ca 2+ -regulated release of opioid peptides [PDF]
, 2016 Opioids are the most powerful analgesics. As pain is driven by sensory transmission and opioid receptors couple to inhibitory G proteins, according to the classical concept, opioids alleviate pain by activating receptors on neurons and blocking the ...
Celik, Melih Ö. +15 more
core +1 more source
Homeostatic scaling of dynorphin signaling by a non-canonical opioid receptor
Nature CommunicationsThe endogenous opioid system provides powerful control over emotions, nociception, and motivation among many other fundamental nervous system functions.
Xiaona Li +10 more
doaj +1 more source
Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies
Frontiers in Pharmacology, 2015 The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
doaj +1 more source
Negative affect, pain and sex: The role of endogenous opioids [PDF]
, 2007 Opioid neurotransmission modulates pain and negative affect during psychological stress. To determine whether these effects differ between men and women, the opioid receptor antagonist naltrexone or placebo was administered double-blind to 21 men and 22 ...
Frew, A.K., Drummond, P.D.
core +1 more source
Antagonists Pharmacologically Chaperone Opioid Receptors [PDF]
, 2020 More than 100 people die daily in the United States from opioid-related drug overdoses. µ-Opioid receptor (MOR) antagonists, such as naltrexone (Ntx) and naloxone, partially suppress overdose effects, but also induce supersensitivity to MOR activation ...
Collazo, Andres +3 more
core
Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling
Frontiers in Molecular BiosciencesHemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony +4 more
doaj +1 more source
Boesenbergia rotunda Ethanolic Extract Inhibits Compound Action Potentials via Opioid Receptors
Life Sciences, Medicine and Biomedicine, 2018 Boesenbergia rotunda, traditionally used to relieve stomach, abdomen, joint, muscle, and rheumatic pain was also reported for its antinociceptive effect on a mouse model. However, the possible pain relief effect of Boesenbergia rotunda ethanolic extract (
Banulata Gopalsamy +8 more
doaj +1 more source
Functional analysis of cloned opioid receptors in transfected cell lines [PDF]
, 1996 Opioids modulate numerous central and peripheral processes including pain perception neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors.
Elemer T. Piros +5 more
core +1 more source