Results 31 to 40 of about 2,452,900 (288)

Molecular and cellular mechanisms of the age-dependency of opioid analgesia and tolerance

Molecular Pain, 2012
The age-dependency of opioid analgesia and tolerance has been noticed in both clinical observation and laboratory studies. Evidence shows that many molecular and cellular events that play essential roles in opioid analgesia and tolerance are actually age-
Zhao Jing, Xin Xin, Xie Guo-xi, Palmer Pamela, Huang Yu-guang   +4 more
doaj   +1 more source

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

Molecules, 2021
Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa, Kanako Miyano, Hideaki Fujii, Takaaki Mizuguchi, Yui Kuroda, Miki Nonaka, Akane Komatsu, Kaori Ohshima, Masahiro Yamaguchi, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida   +12 more
doaj   +1 more source

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Science Signaling, 2020
Low intrinsic efficacy can explain the reduced side effects of apparently biased μ-opioid receptor agonists. Opioids: Efficacy versus bias Because of its antinociceptive effects, the μ-opioid receptor (MOR) is an important target for pain management, but
A. Gillis, Arisbel B. Gondin, A. Kliewer, Julie Sanchez, Herman D. Lim, Claudia Alamein, Preeti Manandhar, Marina J Santiago, S. Fritzwanker, F. Schmiedel, Timothy A. Katte, Tristan A. Reekie, N. Grimsey, M. Kassiou, B. Kellam, C. Krasel, M. Halls, M. Connor, J. R. Lane, S. Schulz, M. Christie, Meritxell Canals   +21 more
semanticscholar   +1 more source

Delta-opioid receptor endocytosis in spinal cord after dermenkephalin activation

BMC Neuroscience, 2000
Background The delta(δ)-opioid receptors belong to the G protein-coupled receptors and in vitro studies have shown that δ-opioid receptors undergo an internalization process in response to agonist stimulation.
Gastard Myriam
doaj   +1 more source

Delta opioid receptors regulate temporoammonic-activated feedforward inhibition to the mouse CA1 hippocampus. [PDF]

PLoS ONE, 2013
The opioid system influences learning and memory processes. However, neural mechanisms underlying the modulation of hippocampal activity by opioid receptors remain largely unknown. Here, we compared how mu and delta receptors operate within the mouse CA1
Xavier Rezai, Brigitte L Kieffer, Michel J Roux, Dominique Massotte   +3 more
doaj   +1 more source

Supersensitive Kappa Opioid Receptors Promotes Ethanol Withdrawal-Related Behaviors and Reduce Dopamine Signaling in the Nucleus Accumbens

International Journal of Neuropsychopharmacology, 2015
Background: Chronic ethanol exposure reduces dopamine transmission in the nucleus accumbens, which may contribute to the negative affective symptoms associated with ethanol withdrawal.
J. Rose, Anushree N. Karkhanis, Rong Chen, D. Gioia, Marcelo F. Lopez, H. Becker, B. McCool, S. Jones   +7 more
semanticscholar   +1 more source

Opioid and cannabinoid receptors

Current Opinion in Neurobiology, 1994
Opioids and cannabinoids are two major classes of drugs with important clinical uses as well as significant side effects. Recently, the three major subtypes of opioid receptors, delta, kappa and mu, have been cloned. Both the endogenous cannabinoids and their receptors have also recently been cloned.
Terry Reisine, Michael J. Brownstein
openaire   +3 more sources

Ageism in Rheumatology: The Health Care Professional's Perspective

Arthritis Care &Research, EarlyView.
Objective Ageism (age‐based stereotypes, prejudice, or discrimination) is prevalent and linked to prolonged disability and reduced lifespan in older adults. Little is known about ageism within rheumatology. This study explores the health care professional's (HCP) perception of the care of older adults and how ageist attitudes or perspectives may impact
Aaron P. Smith, Pooja M. Achanta, Jiha Lee, Namrata Singh, Una E. Makris   +4 more
wiley   +1 more source

Molecular Physiology of Enteric Opioid Receptors

The American Journal of Gastroenterology Supplements, 2014
Opioid drugs have powerful antidiarrheal effects and many patients taking these drugs for chronic pain relief experience chronic constipation that can progress to opioid-induced bowel dysfunction.
J. Galligan, H. Akbarali
semanticscholar   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source