Results 31 to 40 of about 55,107 (272)

Neuroimaging for differential diagnosis of transient neurological attacks

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Background Rapid yet comprehensive neuroimaging protocols are required for patients with suspected acute stroke. However, stroke mimics can account for approximately one in five clinically diagnosed acute ischemic strokes and the rate of thrombolyzed mimics can be as high as 17%.
Ying Wang, Hao Zha
wiley   +1 more source

J‐SUPPORT research policy for oral mucositis associated with cancer treatment

Cancer Medicine, Volume 11, Issue 24, Page 4816-4829, December 2022., 2022
Abstract Background Oral mucositis is one of the main areas of research in supportive and palliative care of cancer patients. However, the methodology of prospective clinical trials on oral mucositis has not been established, despite its uniqueness.
Tomoya Yokota, Takao Ueno, Yoshihiko Soga, Hiroto Ishiki, Yasuhito Uezono, Takehiko Mori, Sadamoto Zenda, Yosuke Uchitomi   +7 more
wiley   +1 more source

Pharmacological Profiles of Oligomerized μ-Opioid Receptors

Cells, 2013
Opioids are widely prescribed pain relievers with multiple side effects and potential complications. They produce analgesia via G-protein-protein coupled receptors: μ-, δ-, κ-opioid and opioid receptor-like 1 receptors.
Ing-Kang Ho, Cynthia Wei-Sheng Lee
doaj   +1 more source

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

Molecules, 2021
Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa, Kanako Miyano, Hideaki Fujii, Takaaki Mizuguchi, Yui Kuroda, Miki Nonaka, Akane Komatsu, Kaori Ohshima, Masahiro Yamaguchi, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida   +12 more
doaj   +1 more source

Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer

Cancer Medicine, Volume 11, Issue 24, Page 5001-5012, December 2022., 2022
Nerve invasion (N‐inv) is an important prognostic factor in pancreatic ductal adenocarcinoma (PDAC). To elucidate circulating stimulators for nerve invasion, the authors evaluated the stimulant activity and the inhibitory effects of IL‐6/gp130 axis. Biological activity of IL‐6/gp130 axis promoted nerve invasion in murine model and was upregulated in ...
Hidetaka Suzuki, Shuichi Mitsunaga, Masafumi Ikeda, Takao Aoyama, Kazumi Yoshizawa, Masayuki Yamaguchi, Masami Suzuki, Minoru Narita, Toshikatsu Kawasaki, Atsushi Ochiai   +9 more
wiley   +1 more source

Peripheral sensitization increases opioid receptor expression and activation by crotalphine in rats.

PLoS ONE, 2014
Inflammation enhances the peripheral analgesic efficacy of opioid drugs, but the mechanisms involved in this phenomenon have not been fully elucidated. Crotalphine (CRP), a peptide that was first isolated from South American rattlesnake C.d.
Vanessa Olzon Zambelli, Ana Carolina de Oliveira Fernandes, Vanessa Pacciari Gutierrez, Julio Cesar Batista Ferreira, Carlos Amilcar Parada, Daria Mochly-Rosen, Yara Cury   +6 more
doaj   +1 more source

BmK-YA, an enkephalin-like peptide in scorpion venom. [PDF]

PLoS ONE, 2012
By screening extracts of venom from the Asian scorpion Buthus martensii Karsch (BmK) for their abilities to activate opioid receptors, we have identified BmK-YA, an amidated peptide containing an enkephalin-like sequence. BmK-YA is encoded by a precursor
Yan Zhang, Junyan Xu, Zhiwei Wang, Xiuli Zhang, Xinmiao Liang, Olivier Civelli   +5 more
doaj   +1 more source

Machine-learning Repurposing of DrugBank Compounds for Opioid Use Disorder [PDF]

arXiv, 2023
Opioid use disorder (OUD) is a chronic and relapsing condition that involves the continued and compulsive use of opioids despite harmful consequences. The development of medications with improved efficacy and safety profiles for OUD treatment is urgently needed.
arxiv  

Dose of intra‐operative opioids has no impact on recurrence or survival in primary liver cancer

Cancer Medicine, Volume 11, Issue 24, Page 4927-4934, December 2022., 2022
Kaplan‐meier curves for recurrence‐free and overall survial of high‐dose and low‐dose groups. No significant difference in recurrence‐free survial (A) or overall survial (B) after surgery was noted when comparing high‐dose with low‐dose groups. Abstract Background Intra‐operative use of opioid analgesics might have an impact on cancer recurrence and ...
Liuyuan Zhao, Lei Teng, Wenhui Zhang, Shiyan Lin, Xuejiao Liu, Junzhu Dai, Hongxue Shao, Xiaoshi Li, Quan Liu, Huichao Zou   +9 more
wiley   +1 more source

Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use

Addiction Neuroscience, 2023
Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals.
Sarah B. Ethridge, Mark A. Smith
doaj