Results 41 to 50 of about 118,382 (307)

A Theory of Natural Addiction [PDF]

, 2007
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Ainslie, Atkinson, Attila Tasnádi, Baldwin, Baron-Cohen, Becker, Becker, Bergstrom, Blass, Blass, Blass, Bodnar, Booth, Brick, Camerer, Camerer, Campbell, Carson-DeWitt, Chiara, Cohen, Colantuoni, Cooper, Cooper, Cummings, Deth, Drewnowski, Dudley, Dum, Fantino, Fehr, Foster, Gilbertson, Gillberg, Gosnell, Griffiths, Grossman, Gruber, Gul, Harrigan, Headlee, Hirshleifer, Hirshleifer, Holtzman, Jaffe, Kahneman, Kalat, Kavaliers, Kavaliers, Killian, Laibson, Laibson, Leboyer, Leboyer, Loewenstein, Martin, McKim, Mello, Mercer, Morley, Mucha, Mucha, Nelson, Nesse, Nesse, Orphanides, Orphanides, Ostrowski, Parfitt, Pert, Pomerleau, Raiten, Raven, Robson, Rogers, Rudski, Samuelson, Sanger, Savage, Schuckit, Si, Simon, Simpkins, Smith, Sozou, Spanagel, Sullivan, Sullivan, ter Riet, Terenius, Trenton G. Smith, van Ree, van Ree, van Ree, Waeltl, Weeks, Weeks, Weiss, Williams, Yamamoto, Yeomans, Yeomans, Yeomans, Zigmond   +102 more
core   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Delta opioid receptors regulate temporoammonic-activated feedforward inhibition to the mouse CA1 hippocampus. [PDF]

PLoS ONE, 2013
The opioid system influences learning and memory processes. However, neural mechanisms underlying the modulation of hippocampal activity by opioid receptors remain largely unknown. Here, we compared how mu and delta receptors operate within the mouse CA1
Xavier Rezai, Brigitte L Kieffer, Michel J Roux, Dominique Massotte   +3 more
doaj   +1 more source

Solid Tumor Opioid Receptor Expression and Oncologic Outcomes: Analysis of the Cancer Genome Atlas and Genotype Tissue Expression Project

Frontiers in Oncology, 2022
BackgroundOpioid receptors are expressed not only by neural cells in the central nervous system, but also by many solid tumor cancer cells. Whether perioperative opioids given for analgesia after tumor resection surgery might inadvertently activate tumor
Amparo Belltall, Amparo Belltall, Sheila Zúñiga-Trejos, Iris Garrido-Cano, Iris Garrido-Cano, Pilar Eroles, Pilar Eroles, Maria Pilar Argente-Navarro, Maria Pilar Argente-Navarro, Donal J. Buggy, Donal J. Buggy, Oscar Díaz-Cambronero, Oscar Díaz-Cambronero, Oscar Díaz-Cambronero, Guido Mazzinari, Guido Mazzinari, Guido Mazzinari   +16 more
doaj   +1 more source

M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]

, 2017
Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa, Lopez-Gimenez, Juan, Milligan, Graeme   +2 more
core   +1 more source

Evaluation of the analgesic effect of 4-anilidopiperidine scaffold containing ureas and carbamates [PDF]

, 2016
Fentanyl is a powerful opiate analgesic typically used for the treatment of severe and chronic pain, but its prescription is strongly limited by the well-documented side-effects.
Benyhe, Sa ́ndor, CARRADORI, Simone, Csaba To ̈mbo ̈ly, Erdei, Anna I., Ferenc O. ̈tvos, Ferenc Za ́dor, Fidanza, Lorenzo, Marzoli, Francesca, Mirzaie, Sako, MOLLICA, Adriano, MONTI, LUDOVICA, Moriello, Aniello Schiano, Novellino, Ettore, Petrocellis, Luciano De, PIERETTI, stefano, Samavati, Reza, STEFANUCCI, AZZURRA, Szabolcs Dvora ́csko, Szucs, Edina   +18 more
core   +1 more source

Health disparities in chronic liver disease

Hepatology, EarlyView., 2022
Abstract The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations.
Ani Kardashian, Marina Serper, Norah Terrault, Lauren D. Nephew   +3 more
wiley   +1 more source

Opioids and opioid receptors; understanding pharmacological mechanisms as a key to therapeutic advances and mitigation of the misuse crisis

BJA Open, 2023
Opioids are a mainstay in acute pain management and produce their effects and side effects (e.g., tolerance, opioid-use disorder and immune suppression) by interaction with opioid receptors.
David G. Lambert
doaj   +1 more source

The unsolved case of “bone-impairing analgesics”. The endocrine effects of opioids on bone metabolism [PDF]

, 2015
The current literature describes the possible risks for bone fracture in chronic analgesics users. There are three main hypotheses that could explain the increased risk of fracture associated with central analgesics, such as opioids: 1) the increased ...
COLUZZI, FLAMINIA, MATTIA, Consalvo, Pergolizzi, Joseph, Raffa, Robert B   +3 more
core   +3 more sources

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source