Results 41 to 50 of about 3,424 (135)
JOR SPINE, Volume 8, Issue 4, December 2025.Cutibacterium acnes and Staphylococcus aureus antigens were detected within non‐herniated intervertebral discs and correlated with catabolic and pyroptotic markers (MMP‐3, GSDMD) and PRRs including NOD2. NP cells exposed to bacterial peptidoglycan showed MAPK/NF‐κB activation and catabolic cytokine release, suggesting that bacterial sensing through a ...
Andrea Nüesch +5 more
wiley +1 more source
Loss of myocardial LIF receptor in experimental heart failure reduces cardiotrophin-1 cytoprotection. A role for neurohumoral agonists? [PDF]
, 2007 OBJECTIVES: Cardiomyocyte loss is involved in the transition from compensatory left ventricular hypertrophy (LVH) to heart failure (HF). Our aim was to investigate the status of the leukaemia inhibitory factor receptor (LIFR)/gp130 survival pathway and ...
Diez-Martinez, J. (Javier) +3 more
core +1 more source
JOR SPINE, Volume 8, Issue 4, December 2025.Here, the development of media compositions to mimic the healthy and degenerate IVD has been achieved. Human NP cells and explants were successfully cultured within these media without any detectable loss of viability and minimal secretomic changes. The main effects observed within cultures were seen with the addition of physiological concentrations of
Joseph Snuggs +6 more
wiley +1 more source
Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway [PDF]
, 2011 Background Elevated brain levels of the pleiotropic cytokine interleukin-6, which is mainly secreted from activated local astrocytes, contribute to pathological events including neuroinflammation and neurodegeneration. Thus, inhibition of pathological IL-
Ingo Schulz +8 more
core +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S259-S306, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Epileptogenesis in meningioma: Theories, putative biomarkers, and postoperative risk
Epilepsia, Volume 66, Issue 11, Page 4079-4090, November 2025.Abstract Cranial meningioma are the most common type of primary brain tumor, and focal onset, tumor‐related seizures affect a significant proportion of patients. Seizures affect 30% of symptomatic preoperative patients and a further 12% of postoperative patients.
William H. Cook +5 more
wiley +1 more source
IL-12 Family Cytokines: General Characteristics, Pathogenic Microorganisms, Receptors, and Signalling Pathways [PDF]
, 2016 Among a wide range of cytokines, the Interleukin 12 (IL-12) family has its unique structural, functional, and immunological characteristics that have made this family as important immunological playmakers. Because of the importance of IL-12 heterodimeric
Behzadi, Elham +2 more
core +1 more source
MedComm, Volume 6, Issue 9, September 2025.Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao +12 more
wiley +1 more source
Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations [PDF]
, 2008 Introduction Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly targets the exocrine glands. The aim of this study was to investigate the involvement of 87 proteins measured in serum and 75 proteins analyzed in saliva in spontaneous ...
Delaleu, Nicolas Hervé +3 more
core +1 more source
Small Science, Volume 5, Issue 9, September 2025.Surface modification of quasi‐2D perovskite films with CsX (X = Cl, Br, I) nanocrystals enables tunable photoluminescence across the visible spectrum. Selective halide exchange or structural phase transformation occurs at the interface, governed by kinetic differences.
Dong Il Son +10 more
wiley +1 more source