Results 191 to 200 of about 21,293 (242)
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Localization of parathyroid hormone/parathyroid hormone-related peptide receptor mRNA in kidney
American Journal of Physiology-Renal Physiology, 1996In kidney, parathyroid hormone (PTH) exerts differential distal effects along the nephron. To define cells expressing receptors for PTH in kidney, we localized PTH/ PTH-related peptide (PTH/PTHrP) receptor mRNA in rat kidney by in situ hybridization. PTH/PTHrP receptor mRNA is localized to glomerular podocytes, convoluted and straight proximal tubules,
K, Lee +6 more
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American Journal of Physiology-Endocrinology and Metabolism, 1999
The aim of this study was to investigate the possibility that an abnormality related to parathyroid hormone (PTH) action is involved in the increased bone turnover observed in otosclerosis. To do so, expression and function of the PTH-PTH-related peptide (PTHrP) receptor were studied in the involved tissue (stapes) and compared with that in control ...
A B, Grayeli +5 more
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The aim of this study was to investigate the possibility that an abnormality related to parathyroid hormone (PTH) action is involved in the increased bone turnover observed in otosclerosis. To do so, expression and function of the PTH-PTH-related peptide (PTHrP) receptor were studied in the involved tissue (stapes) and compared with that in control ...
A B, Grayeli +5 more
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Biochemistry, 1998
Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated after PTH treatment. Since downregulation may involve receptor phosphorylation, we examined PTH/PTHrP receptor phosphorylation in ROS 17/2.8 cells and we mapped the agonist-induced phosphorylation sites using recombinant PTH/PTHrP receptors expressed in LLCPK-1 and COS-7 cells.
F, Qian, A, Leung, A, Abou-Samra
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Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated after PTH treatment. Since downregulation may involve receptor phosphorylation, we examined PTH/PTHrP receptor phosphorylation in ROS 17/2.8 cells and we mapped the agonist-induced phosphorylation sites using recombinant PTH/PTHrP receptors expressed in LLCPK-1 and COS-7 cells.
F, Qian, A, Leung, A, Abou-Samra
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A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide
Science, 1991The complementary DNA encoding a 585-amino acid parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning domains was cloned by COS-7 expression using an opossum kidney cell complementary DNA (cDNA) library.
Harald Jüppner +10 more
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Bone, 1999
The molecular cloning of the PTH/PTHrP receptor (also termed PTH1 receptor; PTH1R) and the receptors for calcitonin and secretin established a distinct family of G protein-coupled receptors. These receptors are characterized by seven membranespanning domains, a long amino-terminal extracellular domain, and a long carboxyl-terminal intracellular tail ...
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The molecular cloning of the PTH/PTHrP receptor (also termed PTH1 receptor; PTH1R) and the receptors for calcitonin and secretin established a distinct family of G protein-coupled receptors. These receptors are characterized by seven membranespanning domains, a long amino-terminal extracellular domain, and a long carboxyl-terminal intracellular tail ...
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Parathyroid hormone: new assays, new receptors
Seminars in Nephrology, 2004Accurate measurements of parathyroid hormone (PTH) in plasma are necessary for the assessment, monitoring, and therapy of disorders of bone and mineral metabolism including renal osteodystrophy. Assays for PTH have evolved to provide 2-site immunometric assays that are highly specific for the intact 84 amino-acid peptide, PTH (1-84). With the advent of
Kevin J, Martin +2 more
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Receptors | Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor
2021Thomas J. Gardella, Justin J. Miller
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Identification of a Receptor-Binding Region in Parathyroid Hormone*
Endocrinology, 1980Analyses of structure/activity relations for parathyroid hormone (PTH) have revealed that the sequence PTH- (1–34) is fully active in all known bioassay systems and that deletion of the first two amino-terminal residues results in the loss of all or virtually all biological activity but not in the loss of the property of binding to renal receptors in ...
M, Rosenblatt +5 more
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Parathyroid hormone and parathyroid hormone-related protein receptor update
Molecular and Cellular Endocrinology, 1994Muff R, Born W, Kaufmann M, Fischer JA
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Parathyroid Hormone and Its Receptors
1998Publisher Summary This chapter discusses the parathyroid hormone and its receptors. Parathyroid hormone (PTH) is synthesized in the parathyroid cells as a pre-pro-hormone comprised of 115 amino acids. The signal peptide of PTH allows translocation of the polypeptide into the secretory vesicles, a property that is shared with most secreted proteins ...
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