Results 91 to 100 of about 4,265,108 (334)

In-silico design of peptide receptor for carboxyhemoglobin recognition

Informatics in Medicine Unlocked, 2019
A series of peptide receptors were designed using an in-silico approach for the recognition of the heme prosthetic group in carboxyhemoglobin (COHb). These peptide chains were designed from the amino acids present in the enzyme Cytochrome b561 (Cyt b561)
Rodríguez-Salazar Luna, Guevara-Pulido James, Morales-Mendoza Esteban, Ibla Francisco   +3 more
doaj   +1 more source

Transcriptome of the female synganglion of the black-legged tick Ixodes scapularis (Acari: Ixodidae) with comparison between Illumina and 454 systems. [PDF]

PLoS ONE, 2014
Illumina and 454 pyrosequencing were used to characterize genes from the synganglion of female Ixodes scapularis. GO term searching success for biological processes was similar for samples sequenced by both methods.
Noble Egekwu, Daniel E Sonenshine, Brooke W Bissinger, R Michael Roe   +3 more
doaj   +1 more source

Co-expressed peptide receptors in breast cancer as a molecular basis for in vivo multireceptor tumour targeting [PDF]

, 2018
Breast cancers can express different types of peptide receptors such as somatostatin, vasoactive intestinal peptide (VIP), gastrin-releasing peptide (GRP) and NPY(Y1) receptors. The aim of this in vitro study was to evaluate which is the most appropriate
Gugger, Mathias, Reubi, Jean, Waser, Beatrice   +2 more
core  

Robust anti‐obesity and metabolic effects of a dual GLP‐1/glucagon receptor peptide agonist in rodents and non‐human primates

Diabetes, obesity and metabolism, 2016
To characterize the pharmacology of MEDI0382, a peptide dual agonist of glucagon‐like peptide‐1 (GLP‐1) and glucagon receptors.
S. Henderson, A. Konkar, D. Hornigold, James L. Trevaskis, R. Jackson, M. F. Fredin, R. Jansson-Löfmark, Jacqueline Naylor, Alessandra Rossi, M. Bednarek, N. Bhagroo, H. Salari, S. Will, Stephanie N. Oldham, G. Hansen, M. Feigh, T. Klein, J. Grimsby, S. Maguire, L. Jermutus, C. Rondinone, M. Coghlan   +21 more
semanticscholar   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission

eLife, 2016
Plants constantly renew during their life cycle and thus require to shed senescent and damaged organs. Floral abscission is controlled by the leucine-rich repeat receptor kinase (LRR-RK) HAESA and the peptide hormone IDA.
J. Santiago, B. Brandt, M. Wildhagen, U. Hohmann, L. Hothorn, M. Butenko, M. Hothorn   +6 more
semanticscholar   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Global analysis of neuropeptide receptor conservation across phylum Nematoda

BMC Biology
Background The phylum Nematoda is incredibly diverse and includes many parasites of humans, livestock, and plants. Peptide-activated G protein-coupled receptors (GPCRs) are central to the regulation of physiology and numerous behaviors, and they ...
Luca Golinelli, Ellen Geens, Allister Irvine, Ciaran J. McCoy, Elke Vandewyer, Louise E. Atkinson, Angela Mousley, Liesbet Temmerman, Isabel Beets   +8 more
doaj   +1 more source

Structure–Function Relationships of Glycine and GABAA Receptors and Their Interplay With the Scaffolding Protein Gephyrin

Frontiers in Molecular Neuroscience, 2018
Glycine and γ-aminobutyric acid (GABA) are the major determinants of inhibition in the central nervous system (CNS). These neurotransmitters target glycine and GABAA receptors, respectively, which both belong to the Cys-loop superfamily of pentameric ...
Vikram B. Kasaragod, Hermann Schindelin
doaj   +1 more source

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]

, 1992
We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G., Atherton E., Atherton E., Baenziger J. U., Christian Plank, Connolly D. T., Corley Cain C., Curiel D. T., DeWet J., Ellman G. L., Ernst Wagner, Gotten M., Gotten M., Gotten M., Huckett B., Karl Mechtler, Kempen H. J. M., Knowles B. B., Kurt Zatloukal, Lee Y. C., Matt Cotten, Orrantia E., Patek P.Q., Rosenkranz A. A., Seifter S., Severne Y., Spiess M., Tam J. P., Wagner E., Wagner E., Wagner E., Wagner E., Wharton S. A., Wu C., Wu G. Y., Zatloukal K., Zenke M.   +36 more
core   +1 more source