Results 291 to 300 of about 4,287,179 (359)

Peptide‐Based Carbohydrate Receptors

Chemistry – A European Journal, 2014
AbstractA broad spectrum of physiological processes is mediated by highly specific noncovalent interactions of carbohydrates and proteins. In a recent communication we identified several cyclic hexapeptides in a dynamic combinatorial library that interact selectively with carbohydrates with high binding constants in water.
Melanie, Rauschenberg, Sateesh, Bandaru, Mark P, Waller, Bart Jan, Ravoo   +3 more
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Non-peptide ligands for peptide receptors

Trends in Pharmacological Sciences, 1989
Considerable progress has been made in synthesizing peptide analogs with improved stability for probing function of peptide-receptor systems. However, since peptide ligands are usually unsuitable for development as potent orally active long-duration therapeutic agents, considerable research effort is being directed to the development of non-peptidal ...
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Peptide YY receptors in the brain

Biochemical and Biophysical Research Communications, 1988
Radiolabelled ligand binding studies demonstrated that specific receptors for peptide YY are present in the porcine as well as the canine brains. Peptide YY was bound to brain tissue membranes via high-affinity (dissociation constant, 1.39 X 10(-10)M) and low-affinity (dissociation constant, 3.72 X 10(-8)M) components.
A, Inui, M, Oya, M, Okita, T, Inoue, N, Sakatani, H, Morioka, K, Shii, K, Yokono, N, Mizuno, S, Baba   +9 more
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International Union of Pharmacology. XVIII. Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide.

Pharmacological Reviews, 1998
Vasoactive intestinal peptide (VIPb) and pituitary adenylate cyclase-activating polypeptide (PACAP) are members of a superfamily of structurally related peptide hormones that includes glucagon, glucagon-like peptide, secretin, and growth hormone ...
A. Harmar, A. Arimura, I. Gozes, L. Journot, M. Laburthe, J. Pisegna, S. Rawlings, P. Robberecht, S. Said, S. Sreedharan, S. Wank, J. Waschek   +11 more
semanticscholar   +1 more source

Receptor antagonists for gastrointestinal peptides

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993
Receptors for gastrointestinal peptides are all G protein-coupled receptors. Since the discovery that dibutyryl guanosine 3',5'-cyclic monophosphate was a cholecystokinin-receptor antagonist, a variety of receptor antagonists have been developed for a number of different gastrointestinal peptides.
M E, Presti, J D, Gardner
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Relaxin Family Peptides and Their Receptors

Physiological Reviews, 2013
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as a vasodilator and cardiac stimulant in the cardiovascular system, and as an antifibrotic agent.
Bathgate, RAD, Halls, ML, van der Westhuizen, ET, Callander, GE, Kocan, M, Summers, RJ   +5 more
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Biology of natriuretic peptides and their receptors

Peptides, 2005
Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals, including renal hemodynamics, neuroendocrine, and cardiovascular functions. Collectively, NPs are classified as hypotensive hormones; the main actions of NPs are implicated in eliciting natriuretic, diuretic, steroidogenic, antiproliferative, and vasorelaxant ...
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pH profile of a peptide receptor

Comparative Biochemistry and Physiology, 1969
Abstract 1. 1. The activation of the feeding response in Hydra littoralis was used as a model system to investigate the mechanism by which a specific peptide activates its complementary cellular receptor to give a co-ordinated biological response. 2. 2. Through use of a modified Lineweaver-Burk equation and a modified Dixon equation, it was
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Peptide hormone and receptor evolution

General and Comparative Endocrinology, 2007
An important and fascinating theme that unifies both invertebrate and vertebrate endocrinologists is that of the evolution of peptide precursor and receptor genes. Peptide signalling plays a crucial role in processes that control decisive physiological events in organisms as divergent as yeast and mammals.
Dan, Larhammar, Jozef, Vanden Broeck
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Peptide Antagonist of the Androgen Receptor

Current Pharmaceutical Design, 2010
Androgen receptor (AR) is a steroid hormone receptor that is activated by endogenous androgens, mainly testosterone and 5alpha-dihydrotestosterone (5alpha-DHT). AR is also an important drug target, and AR antagonists (antiandrogens) have been widely used for prostate cancer therapy.
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