Results 71 to 80 of about 4,265,108 (334)

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

Frontiers in Immunology, 2023
Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ interactions between complementarity-determining regions with both peptide and MHC-I heavy chain ...
Georgia F. Papadaki, Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Tyler J. Florio, Michael C. Young, Michael C. Young, Julia N. Danon, Julia N. Danon, Yi Sun, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis, Nikolaos G. Sgourakis   +13 more
doaj   +1 more source

Intracellular interferons in fish : a unique means to combat viral infection [PDF]

, 2013
Peer reviewedPublisher ...
A Lopez-Munoz, A Matsuo, A Pindel, AJ Sadler, B Sun, Bei Huang, Bertrand Collet, C Stein, Chris J. Secombes, CM Ahmed, D Aggad, E Kalie, EL Ooi, F Sun, FF Yu, J Zou, J Zou, J Zou, J Zou, JM Gonzalez-Navajas, Jun Zou, Karen L. Mossman, KE Taylor, M Chang, M Shin-Ya, Ming-Xian Chang, MK Purcell, N Sathish, O Haller, OJ Hamming, PE Phelan, Pin Nie, S Biacchesi, S Campbell, S Long, S Long, SA Martin, SV Kotenko, SY Liu, T Svingerud, V Bergan, Y Palti, YB Zhang, Z Li, Z Qi, Zhanglong Yu   +45 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity

Cell Reports
Summary: Prolactin-releasing peptide receptor (PrRPR), a notable member of the class A peptide-GPCR (G-protein-coupled receptor) family, regulates diverse physiology functions upon activation by PrRP.
Zhangsong Wu, Chen Qiu, Yiming Liu, Xiaoyi Yan, Qiaohui Li, Shirui Jiang, Jun Xu, Xin Pan, Fang Ye, Zhiyi Zhang, Peiruo Ning, Binghao Zhang, Lezhi Xu, Bangning Cheng, Xufu Xiang, Chungen Qian, Yang Du, Geng Chen   +17 more
doaj   +1 more source

Altered density of glomerular binding sites for atrial natriuretic factor in bile duct-ligated rats with ascites [PDF]

, 1991
The renal response to atrial natriuretic factor is blunted in cirrhosis with ascites. This might be due to alterations of renal receptors for atrial natriuretic factor.
Almeida, Arendt, Arendt, Ballermann, Cantin, Chinkers, De Léan, Epstein, Garcia, Gauquelin, Gauquelin, Gerbes, Gerbes, Gerbes, Gerbes, Gines, Kollenda, Kollenda, Kountouras, Laffi, Lang, Lowry, Maack, Misra, Morgan, Munson, Needleman, Olivera, Panos, Petrillo, Salerno, Thibault   +31 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Amylin Receptor 1 Mutagenesis Revealed a Potential Role of Calcitonin Serine 29 in Receptor Interaction

Biomedicines
Background: The amylin receptor is a receptor for the peptide hormone amylin, and its activation is known to reduce body weight. The amylin receptor functions as a heterodimer complex that consists of the calcitonin receptor for peptide hormone ...
Hyeseon Song, Jaehyeok Jang, Minjae Park, Junsu Yun, Jeongwoo Jin, Sangmin Lee   +5 more
doaj   +1 more source

Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors*

Journal of Biological Chemistry, 2012
Background: The α-hemoglobin-derived peptide RVDPVNFKLLSH was found to interact with cannabinoid CB1 receptors. Results: We generated mAbs against RVDPVNFKLLSH and identified a new family of endogenous peptides (Pepcans) that act as negative allosteric ...
M. Bauer, A. Chicca, Marco Tamborrini, D. Eisen, Raissa Lerner, B. Lutz, O. Poetz, G. Pluschke, J. Gertsch   +8 more
semanticscholar   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Plant Leucine-Rich Repeat Receptor Kinase (LRR-RK): Structure, Ligand Perception, and Activation Mechanism

Molecules, 2019
In recent years, secreted peptides have been recognized as essential mediators of intercellular communication which governs plant growth, development, environmental interactions, and other mediated biological responses, such as stem cell homeostasis ...
Sayan Chakraborty, Brian Nguyen, Syed Danyal Wasti, Guozhou Xu   +3 more
doaj   +1 more source