Results 71 to 80 of about 28,584 (233)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Leukotrienes in Atherosclerosis: New Target Insights and Future Therapy Perspectives

Mediators of Inflammation, 2009
Atherosclerosis represents an important chronic inflammatory process associated with several pathophysiological reactions in the vascular wall. The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of
Graziano Riccioni, Alessandra Zanasi, Nicola Vitulano, Barbara Mancini, Nicolantonio D'Orazio   +4 more
doaj   +1 more source

Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature.

PLoS ONE, 2011
Despite wide margins and high dose irradiation, unresectable malignant glioma (MG) is less responsive to radiation and is uniformly fatal. We previously found that cytosolic phospholipase A2 (cPLA(2)) is a molecular target for radiosensitizing cancer ...
Stephen M Schleicher, Dinesh K Thotala, Amanda G Linkous, Rong Hu, Kathleen M Leahy, Eugenia M Yazlovitskaya, Dennis E Hallahan   +6 more
doaj   +1 more source

Anti-Phospholipase A2 Receptor Antibody Testing to the Rescue

Indian Journal of Nephrology
Serological testing for M-type anti-phospholipase A2 receptor antibodies (antiPLA2R Ab) has abrogated the need for kidney biopsy to diagnose membranous nephropathy in the appropriate clinical setting. We report a case of a 63-year-old hypertensive male who presented with nephrotic syndrome associated with autosomal dominant polycystic kidney disease ...
Nath, A.S., Herur, Siddharth, Taduri, Gangadhar, Guditi, Swarnalatha, Kalidindi, Raja Karthik, Murugan, Prasanna, Nair, Rahul R., Ganesh, Niranjan   +7 more
openaire   +2 more sources

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Ceramide and ceramide 1-phosphate in health and disease

Lipids in Health and Disease, 2010
Sphingolipids are essential components of cell membranes, and many of them regulate vital cell functions. In particular, ceramide plays crucial roles in cell signaling processes.
Gómez-Muñoz Antonio, Trueba Miguel, Ouro Alberto, Gangoiti Patricia, Arana Lide   +4 more
doaj   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Suppressive Effects of Bee Venom-Derived Phospholipase A2 on Mechanical Allodynia in a Rat Model of Neuropathic Pain

Toxins, 2019
Bee venom (BV) has a long history of being used in traditional Korean medicine to relieve pain. Here, we investigated the effect of BV-derived phospholipase A2 (bvPLA2), a major component of BV, on peripheral nerve injury-induced neuropathic pain in rats.
Seunghui Woo, Geehoon Chung, Hyunsu Bae, Sun Kwang Kim   +3 more
doaj   +1 more source

From Cold to Hot: Nanozyme‐Based Strategies for Reprogramming the Tumour Immunoenvironment

Cell Proliferation, EarlyView.
Nanozymes, with multi‐enzyme catalytic activities, reprogram the immunosuppressive tumour microenvironment by inducing immunogenic cell death, relieving hypoxia, and depleting antioxidants, effectively converting immunologically “cold” tumours into “hot” ones to boost cancer immunotherapy efficacy.
Yue Wang, Miao Xu, Yongshun Wang, Xuan Lin, Qiang Zhang, Xiaoning Lin, Xin Wu, Cheng Zhang, Wenhua Huang, Jianlin Shen   +9 more
wiley   +1 more source

Updates on intra‐articular corticosteroid administration in horses

Equine Veterinary Education, EarlyView.
Summary Intra‐articular (IA) corticosteroid administration in equine athletes has gained increased attention recently, particularly in racing. Despite widespread corticosteroid use in equine practice for decades, there are still a lack of equine‐specific studies to address key questions related to their use.
K. Tanner, L. Bass, C. Kawcak, L. V. Schnabel, K. L. Hallowell, L. M. Pezzanite   +5 more
wiley   +1 more source