Results 211 to 220 of about 724,506 (298)

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

open access: yesSmall, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu   +12 more
wiley   +1 more source

Electron‐Transfer Engineered Biointerface With Detonation Nanodiamonds for Next‐Generation Cortisol Electrochemical Immunoassay

open access: yesSmall, EarlyView.
Screen‐printed carbon electrode biointerface featuring detonation nanodiamond layer with the sp2/sp3 carbon interface that optimizes charge transfer and enables covalent immobilization of cortisol antibodies. The designed electrochemical sensor provides high selectivity, stability and rapid cortisol detection also from saliva samples.
Chakavak Esmaeili   +3 more
wiley   +1 more source

Nestorone, a potent progestin, exhibits anti-inflammatory activity and prevents preterm birth in murine models of premature labor. [PDF]

open access: yesAm J Obstet Gynecol
Kumar N   +11 more
europepmc   +1 more source

Single‐Vesicle Functional Nanophenotyping Reveals Heterogeneous PD‐L1 Accessibility in Triple‐Negative Breast Cancer

open access: yesSmall Methods, EarlyView.
Graphical Abstract. High‐speed atomic force microscopy enables real‐time, label‐free visualization of antibody interactions with individual extracellular vesicles. By quantifying binding frequency and dwell time, this approach reveals functional PD‐L1 accessibility that cannot be inferred from protein abundance alone, uncovering nanoscale heterogeneity
Reon Imakawa   +10 more
wiley   +1 more source

Diflubenzuron Caused Mitochondrial Dysfunction, Ca2+ Homeostasis Disruption, and Intrinsic Apoptosis in Trophoblastic Cells

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Diflubenzuron is used as an insect growth inhibitor, and its potential risk to human health was raised owing to the possibility of environmental residues and human exposure. This study aimed to investigate the toxic mechanism of diflubenzuron on trophoblastic cells such as HTR8/SVneo and JEG‐3 cells. We investigated mitochondrial function, Ca2+
Miji Kim   +4 more
wiley   +1 more source

Effects of Micronized Progesterone in Menopausal Hormone Replacement Therapy on Sleep. [PDF]

open access: yesJ Obstet Gynaecol Res
Hirose A   +6 more
europepmc   +1 more source

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