Results 271 to 280 of about 93,312 (311)
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Platelet Prostaglandin Receptors
1997Prostanoids, consisting of prostaglandins (PGs) and thromboxane (TX), are oxygenated metabolites of arachidonic acids. They are produced by a variety of cells in response to stimuli and are released from the cells immediately after synthesis. They exert a variety of actions in the body that are mediated via cell surface receptors specific for each ...
F. Ushikubi, M. Hirata, S. Narumiya
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Prostaglandin Receptors: Advances in the Study of EP3 Receptor Signaling
Journal of Biochemistry, 2002Prostaglandin (PG) E(2) produces a broad range of physiological and pharmacological actions in diverse tissues through specific receptors on plasma membranes for maintenance of local homeostasis in the body. PGE receptors are divided into four subtypes, EP1, EP2, EP3, and EP4, which have been identified and cloned. These EP receptors are members of the
Noriyuki, Hatae +2 more
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Distribution of prostaglandin E2 and prostaglandin F2α receptors in human myometrium
Acta Endocrinologica, 1981Abstract. Human myometrium was studied for specific binding of PGE2 and PGF2α. PGF2α-binding was almost undetectable, but specific binding sites for PGE2 with high affinity (KD = 2.7 ± 0.4 × 10−9 m were demonstrated. The binding capacity for PGE2 exhibited a topically different distribution pattern with the highest values in the central parts and low ...
T, Bauknecht +4 more
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Frontiers in Bioscience, 2007
Parturition is composed of five separate but integrated physiological events: fetal membrane rupture, cervical dilatation, myometrial contractility, placental separation, and uterine involution. Prostaglandins (PGs) have central roles in each of these events, but the most studied is myometrial contraction.
David M, Olson, Christina, Ammann
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Parturition is composed of five separate but integrated physiological events: fetal membrane rupture, cervical dilatation, myometrial contractility, placental separation, and uterine involution. Prostaglandins (PGs) have central roles in each of these events, but the most studied is myometrial contraction.
David M, Olson, Christina, Ammann
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Prostaglandin receptors in the airways.
Ciba Foundation symposium, 1981An analysis of the effects of some natural prostaglandins and of synthetic analogues with more selective actions points to the existence of several receptors for prostaglandins in the airways. Three effects have been studied: the contraction and relaxation of bronchial smooth muscle in vitro and the cough elicited by inhalation of prostaglandin ...
H O, Collier, P J, Gardiner
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Prostaglandin Receptors Involved in Inflammatory Events
1997Prostaglandin E2 is released at the site of an inflammatory response, but the consequences are not always easy to predict. This is because both pro- and anti-inflammatory actions of PGE2 can be demonstrated in different experimental models (1).
R L, Jones, R A, Armstrong, H, Wise
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On the molecular structure of some prostaglandin receptors
Prostaglandins and Medicine, 1979Hypotheses are presented of the detailed molecular structure of two prostaglandin receptors both concerned in tumor-promotion processes. These structures have been derived by the comparison of the molecular structure of agents active at the site with (i) a simple theoretical protein structure and (ii) the known x-ray structure of phospholipase A2. The
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Thrombosis Research, 1977
Abstract Platelet aggregation and secretion induced by PGG 2 and by analogues of PGH 2 and PGE 2 were inhibited by NO164. Inhibition was apparently competitive (K i ∼ 20 μM). Responses to ADP, vasopressin and arachidonic acid were unaffected. Inhibition of ADP-induced platelet aggregation by PGD 2 and PGE 2 (but not by PGE 1 ) was antagonised ...
D E, MacIntyre, J L, Gordon
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Abstract Platelet aggregation and secretion induced by PGG 2 and by analogues of PGH 2 and PGE 2 were inhibited by NO164. Inhibition was apparently competitive (K i ∼ 20 μM). Responses to ADP, vasopressin and arachidonic acid were unaffected. Inhibition of ADP-induced platelet aggregation by PGD 2 and PGE 2 (but not by PGE 1 ) was antagonised ...
D E, MacIntyre, J L, Gordon
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Regulation of Prostaglandin Receptors in Myocardial Ischemia
1995Sarcolemmal membranes from pig hearts express a homogenous class of binding sites for [3H]PGE1. Competition binding studies with EP receptor suptype selective ligands suggest an EP3 receptor subtype. The GTP analogue GTP gamma S reduced affinity without changing binding capacity, indicating a G protein coupled EP3 receptor. Regional myocardial ischemia
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Prostaglandin I receptor and prostaglandin D receptor
Journal of Lipid Mediators and Cell Signalling, 1995M, Hirata, F, Ushikubi, S, Narumiya
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