Results 261 to 270 of about 93,312 (311)

Prostaglandins and their receptors

1996
Euler’s description that seminal vesicles contain a prostate-derived hypotonic activity [1] causing various pharmacological effects initiated an intense search for the active entities, the prostaglandins. This marks the beginning of the study of paracrine hormonal regulation in tissues. Research revealed that arachidonic acid, which is cleaved from the
Karl-Heinz Thierauch, Harald Dinter, Günter Stock   +2 more
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Prostaglandin F2α Receptor-Dependent Regulation of Prostaglandin Transport

Molecular Pharmacology, 2001
Prostaglandin (PG) F(2alpha) may act on its G protein-coupled receptor (FP) or be imported intracellularly via a transporter, which has high affinity for PGF(2alpha) and PGE(2), but not prostacyclin (PGI(2)). In cells overexpressing the epitope-tagged FP together with the human prostaglandin transporter (hPGT), stimulation of the FP with PGF(2alpha) (1
R, Vezza, J, Rokach, G A, FitzGerald
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Evaluation of prostaglandin-receptors in human and rat liver: Interspecies differences at the prostaglandin receptor-level

Prostaglandins, 1988
The properties of PGE1-, PGE2- and iloprost (stable PGI2-analogue)-binding sites on normal human and rat liver surface cell membranes were investigated. The specific binding of [3H]PGE1 to human (rat) liver surface cell membranes could be displaced most effectively by unlabeled PGE1 (IC-50:2.5 +/- 1.7, (6.1 +/- 2.1) microM) and the specific binding of [
I, Virgolini, C, Müller, M, Hermann, W, Schütz, H, Sinzinger   +4 more
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Conformations of Prostaglandin F _2α and Recognition of Prostaglandins by Their Receptors

Science, 1977
The conformation of prostaglandin F 2α (PGF 2α ) has been determined by x-ray diffraction techniques. Two independent conformers of PGF 2α , studied as the tris(hydroxymethyl)methylamine salt, are observed to adopt the familiar "hairpin" conformation with the α and ω ...
D A, Langs, M, Erman, G T, DeTitta
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Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1-EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation.
Kohichi, Kawahara, Hirofumi, Hohjoh, Tomoaki, Inazumi, Soken, Tsuchiya, Yukihiko, Sugimoto   +4 more
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Prostaglandin Receptor Sensitivity in Psychiatric Disorders

Archives of General Psychiatry, 1986
The cyclic adenosine monophosphate (cAMP) responses to prostaglandin E1 (PGE1) in platelets and leukocytes from drug-free schizophrenic patients, depressive patients, and normal controls have been compared. Both schizophrenic and depressive patients had a significantly lower platelet cAMP response to PGE1 than controls.
P D, Kanof, C, Johns, M, Davidson, L J, Siever, E F, Coccaro, K L, Davis   +5 more
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Receptors for thromboxane and prostaglandins

1984
The elucidation of the structures of thomboxane A2 and prostaglandin D2, E2, F2a and I2, all products of the cyclic endoperoxides PGG2/PGH2, was accompanied by the demonstration of a distinctive biological profile for each compound. Stimulant or inhibitory activity was often observed at nanomolar concentrations.
R. L. Jones, N. H. Wilson, R. A. Armstrong, Y. J. Dong   +3 more
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Trigeminal Nociceptors Express Prostaglandin Receptors

Journal of Dental Research, 2008
Orofacial inflammation is associated with prostaglandin release and the sensitization of nociceptive receptors such as the transient receptor potential subtype V 1 (TRPV 1 ).
A M, Patwardhan, J, Vela, J, Farugia, K, Vela, K M, Hargreaves   +4 more
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Antagonists of the Prostaglandin D2 Receptor CRTH2

Drug News & Perspectives, 2008
Prostaglandin D(2) (PGD(2)) is produced by mast cells, Th2 lymphocytes and dendritic cells and causes activation of Th2 lymphocytes, eosinophils and basophils through a high-affinity interaction with the G protein-coupled receptor chemoattractant homologous receptor expressed on Th2 cells (CRTH2, also known as DP(2)).
Roy, Pettipher, Trevor T, Hansel
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A rapid method for the measurement of prostaglandin receptors

Prostaglandins, Leukotrienes and Medicine, 1982
A method is presented which provides for a simple and rapid determination of prostaglandin receptors in large numbers of tissue samples. Binding of prostaglandin F2 alpha, to preparations of microsomal membranes obtained from the ovaries of PMSG/hCG-treated rats served as the model system for this study.
A, Rotondi, R A, Knazek
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