Results 201 to 210 of about 31,453,429 (295)

Hinokitiol Promotes Neural Repair After Spinal Cord Injury by Reprogramming Microglial Inflammatory and Redox Responses

open access: yesPhytotherapy Research, EarlyView.
Schematic illustration showing that Hinokitiol promotes neural repair after spinal cord injury by activating the Keap1/Nrf2/HO‐1 signaling pathway and reprogramming microglial inflammatory‐redox responses. ABSTRACT Secondary neuroinflammation and oxidative stress, driven partly by maladaptive microglial activation, limit recovery after spinal cord ...
Wenhao Zhang   +10 more
wiley   +1 more source

From Vascular Dysfunction to Atherothrombosis: The Pivotal Role of Eicosanoids and Their Receptors in Platelet and Endothelial Imbalance: A Scoping Review. [PDF]

open access: yesInt J Mol Sci
Ritorto G   +13 more
europepmc   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

open access: yesPhytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li   +14 more
wiley   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

open access: yesRheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura   +3 more
wiley   +1 more source

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

open access: yesSensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa   +5 more
wiley   +1 more source

Engineering with EP2/EP4 knockout and IL-15 transpresentation renders stem cell-derived NK cells self-persistent and resistant to PGE2 inhibition. [PDF]

open access: yesFront Immunol
Vidal-Manrique M   +11 more
europepmc   +1 more source

Gastrointestinal cytoprotection by prostaglandin E and EP receptor subtypes

open access: yesFolia Pharmacologica Japonica, 2001
Koji TAKEUCHI   +2 more
openaire   +2 more sources

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