Results 231 to 240 of about 91,883 (290)

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

The journey of maternal platelets through the utero-placental circulation: routes, interactions, and physiological implications. [PDF]

Mol Hum Reprod
Forstner D, Gauster M, Huppertz B, Lyssy F.   +3 more
europepmc   +1 more source

Allosteric activation of mPR3 by GPR97 triggers PAR2 activation in neutrophils by unmasking novel tethered agonist peptides

Lin H, Chu T, I K, Chen Y, Chang Y, Stacey M, Seiradake E, Bublitz M.   +7 more
europepmc   +1 more source

NETosis and pyroptosis of immune cells in sepsis. [PDF]

J Transl Int Med
Kashif AM, Ouyang Y, Li Y, Pan B.
europepmc   +1 more source

Folinic Acid Improves Healing of Diabetic Foot Ulcers. [PDF]

Wound Repair Regen
Hoke GD, Stone A, Bauer MA, Carter WC, Newsom MR, Boykin JV.   +5 more
europepmc   +1 more source

Human tissue kallikrein 14 induces the expression of IL-6, IL-8, and CXCL1 in skin fibroblasts through protease-activated receptor 1 signaling. [PDF]

FEBS J
Sasiadek L, Bielecka E, Falkowski K, Kulczycka M, Bereta G, Maksylewicz A, Zubrzycka N, Dobosz E, Kozieł J, Drukała J, Lech M, Horbach N, Poręba M, Brix K, Dubin G, Potempa J, Kantyka T.   +16 more
europepmc   +1 more source

Role and regulation of kinases in age-related macular degeneration. [PDF]

J Transl Med
Fang J, Huang Y, Li B, Du Y.
europepmc   +1 more source

Proteinase-Activated Receptors

, 2008
Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4.
Anke Rattenholl, Martin Steinhoff, Stefan W. Schneider, Tobias Görge   +3 more
core   +3 more sources

The therapeutic potential of proteinase-activated receptors in arthritis

Current Opinion in Pharmacology, 2007
Proteinase-activated receptors are a family of seven-transmembrane G-protein-coupled receptors. Activation of PARs is initiated through cleavage of the N-terminus, unmasking a tethered ligand that can then interact with the receptor and lead to its activation. PARs exhibit both anti- and pro-inflammatory properties, although recent evidence has pointed
McIntosh, Kathryn A, Plevin, Robin, Ferrell, William R, Lockhart, John C   +3 more
openaire   +5 more sources