Results 241 to 250 of about 91,883 (290)

Proteinase-Activated Receptors

Pharmacological Reviews, 2001
Proteinase-activated receptors are a recently described, novel family of seven-transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand receptor occupancy, activation is initiated by cleavage of the N terminus of the receptor by a serine protease resulting in the generation of a new tethered ligand that interacts with the ...
S R, Macfarlane, M J, Seatter, T, Kanke, G D, Hunter, R, Plevin   +4 more
openaire   +2 more sources

Proteinase-activated receptors in the nervous system

Nature Reviews Neuroscience, 2003
Recent data point to important roles for proteinases and their cognate proteinase-activated receptors (PARs) in the ontogeny and pathophysiology of the nervous system. PARs are a family of G-protein-coupled receptors that can affect neural cell proliferation, morphology and physiology.
Farshid, Noorbakhsh, Nathalie, Vergnolle, Morley D, Hollenberg, Christopher, Power   +3 more
openaire   +2 more sources

Gastrointestinal functions of proteinase-activated receptors

Life Sciences, 2003
Proteinase-activated receptors (PARs) are a family of G-protein-coupled-seven-trans-membrane-domain receptors, consisting of four family members. PARs, especially PAR-1, a thrombin receptor, and PAR-2, a receptor for trypsin, tryptase and coagulation factors VIIa and Xa, are abundantly distributed throughout the gastrointestinal tract.
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Proteinase-activated receptors in ovine cervical function

Reproduction, Fertility and Development, 2005
In sheep, inflammation not only functions in cervical dilation at parturition, but also plays an important part in the non-pregnant ewe cervix, as demonstrated by the high level of expression of interleukin (IL)-8 at oestrus. Ewes artificially induced to ovulate have significantly lower levels of IL-8 gene expression at oestrus compared with natural ...
Mitchell, SE, Robinson, JJ, King, ME, Williams, LM   +3 more
openaire   +3 more sources

Receptors | Proteinase-Activated Receptors

2021
Pierre E. Thibeault, Morley D. Hollenberg, Rithwik Ramachandran   +2 more
openaire   +1 more source

Proteinase-Activated Receptors

2022
Ricardo J. José, David Woods
openaire   +1 more source

Proteinase-activated Receptors

2006
  +5 more sources

Proteinase-Activated Receptors

2012
  +4 more sources

Proteinase-Activated Receptor 2

2008
Anke Rattenholl, Tobias Görge, Stefan W. Schneider, Martin Steinhoff   +3 more
openaire   +1 more source

Proteinase-activated receptors (PARs)

2008
Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.
Cunningham, Margaret Rose, Plevin, Robin
openaire   +2 more sources