Results 11 to 20 of about 5,101 (183)

Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?

Cells, 2021
Alzheimer’s disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes,
Stefania Gessi, Stefania Merighi, Eva Moretti, Davide Ferrari, Tino Emanuele Poloni, Anna Terrazzan   +5 more
core   +2 more sources

Purinergic signalling: past, present and future

Brazilian Journal of Medical and Biological Research, 2009
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock, Burnstock, G
core   +1 more source

Expression of Purinergic and Endothelial Activation Markers in Brain Tissue From Fatal Microcephaly Associated With ZIKV. [PDF]

Immun Inflamm Dis
ABSTRACT Background Zika virus (ZIKV) is a flavivirus that has gained global attention due to its association with congenital microcephaly and neuroinflammatory responses. Markers of endothelial activation and purinergic signaling have been identified in the context of ZIKV neuropathogenesis, although the underlying mechanisms remain poorly understood.
Sousa JR, Batista Ferro G, Vieira Teixeira L, Silva C, Lima L, Neto O, Azevedo R, Chiang JO, Casseb LMN, Filho AJM, Martins LC, Quaresma JAS, Vasconcelos PFDC.   +12 more
europepmc   +2 more sources

Purinergic Signalling: Therapeutic Developments [PDF]

Frontiers in Pharmacology, 2017
Purinergic signalling, i.e., the role of nucleotides as extracellular signalling molecules, was proposed in 1972. However, this concept was not well accepted until the early 1990's when receptor subtypes for purines and pyrimidines were cloned and ...
Geoffrey Burnstock, Burnstock, G
core   +5 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]

J Trop Med
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc   +2 more sources

Uridine adenosine tetraphosphate is a novel vasodilator in the coronary microcirculation which acts through purinergic P1 but not P2 receptors

Pharmacological Research, 2013
Uridine adenosine tetraphosphate (Up4A) has been identified as an endothelium-derived contracting factor, which acts through purinergic P2X and P2Y receptors. Since the coronary vascular actions of Up4A are unknown, we investigated the vasoactive profile of Up4A in coronary microvessels, and studied the involvement of purinergic receptor subtypes ...
Zhou, Zhichao, Merkus, Daphne, Cheng, Caroline, Duckers, Eric, Danser, Jan, Duncker, Dirk-jan   +5 more
openaire   +3 more sources

The role of purinergic receptors in stem cell differentiation [PDF]

Computational and Structural Biotechnology Journal, 2015
A major challenge modern society has to face is the increasing need for tissue regeneration due to degenerative diseases or tumors, but also accidents or warlike conflicts.
Patrick Babczyk, Constanze Kaebisch, Kaebisch, Constanze, Tobiasch, Edda, Dorothee Schipper, Schipper, Dorothee, Babczyk, Patrick, Edda Tobiasch   +7 more
core   +3 more sources

Adenosine receptors as emerging therapeutic targets for diabetic kidney disease [PDF]

Kidney Research and Clinical Practice, 2022
Diabetic kidney disease (DKD) is now a pandemic worldwide, and novel therapeutic options are urgently required. Adenosine, an adenosine triphosphate metabolite, plays a role in kidney homeostasis through interacting with four types of adenosine receptors
Eun Seon Pak, Jin Joo Cha, Dae Ryong Cha, Keizo Kanasaki, Hunjoo Ha   +4 more
doaj   +1 more source

Purinergic Receptors in Dendritic Cells. [PDF]

J Inflamm Res
Miaomiao Wang,1 Xiaoxiao Zhao,1 Shuai Hou,1 Zhongbo Wu,2 Hai-yan Yin1 1School of Acupuncture and Tuina, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China; 2Brain Disease Research Center, Tongren People’s ...
Wang M, Zhao X, Hou S, Wu Z, Yin HY.
europepmc   +2 more sources

The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy

Frontiers in Immunology, 2023
Extracellular adenosine (eADO) signaling has emerged as an increasingly important regulator of immune responses, including tumor immunity. eADO is mainly produced from extracellular ATP (eATP) hydrolysis.
Chifei Kang, Chifei Kang, Luyu Liu, Chengyu Wu, Lingyun Li, Xiao Jia, Wendi Xie, Siyu Chen, Xinying Wu, Huaxiao Zheng, Jingxin Liu, Rongsong Li, Bin Zeng   +12 more
doaj   +1 more source