Results 11 to 20 of about 8,556 (198)

Purinergic Regulation of Neutrophil Function

Frontiers in Immunology, 2018
Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through ...
Xu Wang, Deyu Chen
doaj   +3 more sources

Expression of Purinergic and Endothelial Activation Markers in Brain Tissue From Fatal Microcephaly Associated With ZIKV. [PDF]

Immun Inflamm Dis
ABSTRACT Background Zika virus (ZIKV) is a flavivirus that has gained global attention due to its association with congenital microcephaly and neuroinflammatory responses. Markers of endothelial activation and purinergic signaling have been identified in the context of ZIKV neuropathogenesis, although the underlying mechanisms remain poorly understood.
Sousa JR, Batista Ferro G, Vieira Teixeira L, Silva C, Lima L, Neto O, Azevedo R, Chiang JO, Casseb LMN, Filho AJM, Martins LC, Quaresma JAS, Vasconcelos PFDC.   +12 more
europepmc   +2 more sources

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease. [PDF]

J Trop Med
Chagas disease, caused by Trypanosoma cruzi, is a neglected tropical disease (NTD) that can lead to severe cardiac complications, including chronic Chagas cardiomyopathy. While NTDs are caused by a variety of pathogens—such as protozoa, bacteria, viruses, and helminths, Chagas disease remains underexplored, particularly regarding host immune responses.
Pereira CSF, Faria RX.
europepmc   +2 more sources

Role of P1 purinergic receptors in myocardial ischemia sensory transduction [PDF]

Cardiovascular Research, 2002
To characterize the role that cardiac sensory P(1) purinergic (adenosine A(1) or A(2)) receptors play in transducing myocardial ischemia.Porcine nodose ganglion cardiac sensory neuron adenosine A(1) or A(2) receptor function was studied in situ during control states as well as in the presence of the peptides bradykinin and substance P or focal ...
G W, Thompson, M, Horackova, J A, Armour
openaire   +2 more sources

Purinergic signaling in the male reproductive tract

Frontiers in Endocrinology, 2022
Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Larissa Berloffa Belardin, Kéliane Brochu, Christine Légaré, Maria Agustina Battistone, Sylvie Breton   +4 more
doaj   +1 more source

Purinergic signaling in the modulation of redox biology

Redox Biology, 2021
Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides and nucleosides. Tri- and diphosphonucleotides are released in physiological and pathological circumstances activating purinergic type 2 receptors (P2 receptors ...
Luiz Eduardo Baggio Savio, Raíssa Leite-Aguiar, Vinícius Santos Alves, Robson Coutinho-Silva, Angela T.S. Wyse   +4 more
doaj   +1 more source

Purinergic Signaling During Hyperglycemia in Vascular Smooth Muscle Cells

Frontiers in Endocrinology, 2020
The activation of purinergic receptors by nucleotides and/or nucleosides plays an important role in the control of vascular function, including modulation of vascular smooth muscle excitability, and vascular reactivity.
Miguel Martin-Aragon Baudel, Ricardo Espinosa-Tanguma, Madeline Nieves-Cintron, Manuel F. Navedo   +3 more
doaj   +1 more source

Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease

Frontiers in Neuroscience, 2021
Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich, Melissa Talita Wiprich, Carla Denise Bonan, Carla Denise Bonan, Carla Denise Bonan   +4 more
doaj   +1 more source

Purinergic Receptors of the Central Nervous System: Biology, PET Ligands, and Their Applications

Molecular Imaging, 2020
Purinergic receptors play important roles in central nervous system (CNS). These receptors are involved in cellular neuroinflammatory responses that regulate functions of neurons, microglial and astrocytes.
Hamideh Zarrinmayeh PhD, Paul R. Territo PhD   +1 more
doaj   +1 more source

ATP as a presynaptic modulator [PDF]

, 2000
© 2000 Elsevier Science Inc.There is considerable evidence that ATP acts as a fast transmitter or co-transmitter in autonomic and sensory nerves mostly through activation of ionotropic P2X receptors but also through metabotropic P2Y receptors. By analogy,
Cunha, Rodrigo A., Ribeiro, J. A.
core   +1 more source