Results 1 to 10 of about 15,217 (185)

Radioligands Targeting the Purinergic P2X Receptors [PDF]

Cells
Purinergic P2X receptors have a wide distribution within the body and modulate a number of physiological processes, being also involved in the development and progression of inflammation-, neuroinflammation-, neurodegeneration-, and cancer-related ...
Diego Dal Ben, Michela Buccioni, Catia Lambertucci, Beatrice Francucci, Aleksei Smirnov, Andrea Spinaci, Gabriella Marucci, Rosaria Volpini   +7 more
doaj   +4 more sources

Identification of ionotrophic purinergic receptors in Huh-7 cells and their response towards structural proteins of HCV genotype 3a [PDF]

Virology Journal, 2011
Hepatitis C virus (HCV) is a major health problem in developing countries including Pakistan. Chronic HCV infection results in progressive liver disease including fibrosis, cirrhosis, insulin resistance and eventually hepatocellular carcinoma (HCC ...
Fatima Kaneez, Butt Sadia, Mehmood Azra, Ashraf Javed, Idrees Muhammad, Manzoor Sobia, Akbar Haji, Rehaman Irshad U, Qadri Ishtiaq   +8 more
doaj   +3 more sources

Pathophysiological Role of Purinergic P2X Receptors in Digestive System Diseases [PDF]

Frontiers in Physiology, 2021
P2X receptors (P2XRs) are trimeric, non-selective cation channels activated by extracellular ATP and widely distributed in the digestive system. P2XRs have an important role in the physiological function of the digestive system, such as neurotransmission,
Qimin An, Qimin An, Gengyu Yue, Gengyu Yue, Xiaoxu Yang, Xiaoxu Yang, Jun Lou, Jun Lou, Weixi Shan, Weixi Shan, Jianhong Ding, Jianhong Ding, Zhe Jin, Zhe Jin, Yanxia Hu, Yanxia Hu, Qian Du, Qian Du, Qiushi Liao, Qiushi Liao, Rui Xie, Rui Xie, Jingyu Xu, Jingyu Xu   +23 more
doaj   +3 more sources

The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

Frontiers in Physiology, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Eilidh eCraigie, Rebecca E Birch, Robert John Unwin, Scott S Wildman   +3 more
doaj   +5 more sources

Activity of Peptides Modulating the Action of p2x Receptors: Focus on the p2x7 Receptor [PDF]

Pharmaceuticals
P2X receptors are a family of ATP-gated ion channels widely distributed in various tissues, especially in neuronal cells and hematopoietic cells. ATP activates P2X receptors, causing the opening of an ionic channel with preferential permeability to the ...
Jonathas Albertino De Souza Oliveira Carneiro, Guilherme Pegas Teixeira, Leandro Rocha, Robson Xavier Faria   +3 more
doaj   +2 more sources

Purinergic signalling: past, present and future [PDF]

Brazilian Journal of Medical and Biological Research, 2009
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock
doaj   +2 more sources

P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology [PDF]

Frontiers in Pharmacology, 2017
Adenosine 5′-triphosphate is a well-known extracellular signaling molecule and neurotransmitter known to activate purinergic P2X receptors. Information has been elucidated about the structure and gating of P2X channels following the determination of the ...
Leanne Stokes, Leanne Stokes, Janice A. Layhadi, Lucka Bibic, Kshitija Dhuna, Samuel J. Fountain   +5 more
doaj   +4 more sources

The Second Transmembrane Domain of P2X7 Contributes to Dilated Pore Formation [PDF]

, 2013
Activation of the purinergic receptor P2X7 leads to the cellular permeability of low molecular weight cations. To determine which domains of P2X7 are necessary for this permeability, we exchanged either the C-terminus or portions of the second ...
A MacKenzie, A Surprenant, AN Shemon, B Gu, BC Suh, BJ Gu, BJ Gu, BM Saunders, BS Khakh, BS Khakh, C Andrei, C Marques-da-Silva, C Sun, C Virginio, Chengqun Sun, CP Lai, D Leon, D Zink, DS Emmett, DS Samways, E Adinolfi, E Bulanova, F Bretschneider, F Rassendren, G Girolomoni, H Gunosewoyo, HJ Bradley, HM Costa-Junior, HZ Hu, JS Wiley, K Schroder, KA Hillman, L Gudipaty, L Stokes, LC Denlinger, LC Denlinger, LE Browne, LH Jiang, LH Jiang, M Li, M Li, Michelle E. Heid, ML Gavala, ML Smart, MT Miras-Portugal, P Marin-Garcia, P Pelegrin, P Pelegrin, Peter A. Keyel, Pierre Bobé, Q Li, R Sluyter, RA North, Russell D. Salter, S Chaumont, S Kracun, S Locovei, S Penuela, S Roger, SD Ohlendorff, SD Silberberg, SL Fernando, SL Fernando, T Kawate, T Sugiyama, TM Egan, V Petrilli, W Duckwitz, Y Shinozaki   +68 more
core   +16 more sources

Purinergic Signaling in Liver Pathophysiology

Frontiers in Endocrinology, 2021
Extracellular nucleosides and nucleotides activate a group of G protein-coupled receptors (GPCRs) known as purinergic receptors, comprising adenosine and P2Y receptors. Furthermore, purinergic P2X ion channels are activated by ATP.
Shanu Jain, Kenneth A. Jacobson
doaj   +1 more source

Molecular and Pharmacological Evidence for the Expression of Multiple Functional P2 Purinergic Receptors in Human Adipocytes

Molecules, 2022
Extracellular ATP exerts important functions as an extracellular signaling molecule via the activation of specific P2 purinergic receptors (P2X and P2Y).
Marco Rossato, Francesca Favaretto, Marnie Granzotto, Marika Crescenzi, Alessandra Boscaro, Angelo Di Vincenzo, Federico Capone, Edoardo Dalla Nora, Eva Zabeo, Roberto Vettor   +9 more
doaj   +1 more source