Results 21 to 30 of about 15,256 (224)

P2-type purinergic signaling in the regulation of pancreatic β-cell functional plasticity as a promising novel therapeutic approach for the treatment of type 2 diabetes?

Frontiers in Endocrinology, 2022
Diabetes Mellitus is a metabolic disorder characterized by a chronic hyperglycemia due to an impaired insulin secretion and a decreased in peripheral insulin sensitivity. This disease is a major public health problem due to it sharp prevalence. Therefore,
Nour Mesto, Jamileh Movassat, Cécile Tourrel-Cuzin   +2 more
doaj   +1 more source

P2X receptors: epithelial ion channels and regulators of salt and water transport. [PDF]

, 2008
When the results from electrophysiological studies of renal epithelial cells are combined with data from in vivo tubule microperfusion experiments and immunohistochemical surveys of the nephron, the accumulated evidence suggests that ATP-gated ion ...
Brian F. King, Bucheimer RE, Dai LJ, Dubyak GR, Egan TM, Inscho EW, King BF, Lazarowski ER, Lazarowski ER, Lehrmann H, Leipziger J, Li L, McCoy DE, North RA, Pelegrin P, Piper AS, Ralevic V, Schwiebert EM, Scott S.P. Wildman, Shirley DG, Taylor AL, Unwin RJ, Vekaria R, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wildman SS, Wolff SC, Zhang Y   +29 more
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ATP ion channel P2X purinergic receptors in inflammation response

Biomedicine & Pharmacotherapy, 2023
Different studies have confirmed that P2X purinergic receptors play a key role in inflammation. Activation of P2X purinergic receptors can release inflammatory cytokines and participate in the progression of inflammatory diseases. In an inflammatory microenvironment, cells can release a large amount of ATP to activate P2X receptors, open non-selective ...
Ji-Peng, Liu, Si-Cheng, Liu, Shi-Qi, Hu, Jia-Feng, Lu, Chang-Lei, Wu, Dong-Xia, Hu, Wen-Jun, Zhang   +6 more
openaire   +2 more sources

Purinergic Receptor Expression and Potential Association with Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Development

Cell Journal, 2017
Objective: Due to recent progress in production of human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-OPCs) for ameliorating myelin disease such as multiple sclerosis (MS) and the role of purinergic signaling in OPCs development,
Shirin Kashfi, Maryam Peymani, Kamran Ghaedi, Hossein Baharvand, Mohammad Hossein Nasr Esfahani, Mohammad Javan   +5 more
doaj   +1 more source

P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes [PDF]

, 2008
ATP plays an important role in signal transduction between neuronal and glial circuits and within glial networks. Here we describe currents activated by ATP in astrocytes acutely isolated from cortical brain slices by non-enzymatic mechanical ...
Kirchhoff, Frank, Lalo, Ulyana, North, R. Alan, Pankratov, Yuriy, Rossner, Moritz J., Verkhratskiĭ, A. N. (Alekseĭ Nestorovich), Wichert, Sven P.   +6 more
core   +1 more source

Purinergic Receptors in Spinal Cord-Derived Ependymal Stem/Progenitor Cells and Their Potential Role in Cell-Based Therapy for Spinal Cord Injury

Cell Transplantation, 2015
Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination ...
Rosa Gómez-Villafuertes Ph.D., Francisco Javier Rodríguez-Jiménez, Ana Alastrue-Agudo, Miodrag Stojkovic, María Teresa Miras-Portugal, Victoria Moreno-Manzano   +5 more
doaj   +1 more source

Purinergic Signaling in Spermatogenesis

Frontiers in Endocrinology, 2022
Adenosine triphosphate (ATP) serves as the essential source of cellular energy. Over the last two decades, however, ATP has also attracted increasing interest as an extracellular signal that activates purinergic plasma membrane receptors of the P2 family.
Nadine Mundt, Nadine Mundt, Nadine Mundt, Lina Kenzler, Marc Spehr, Marc Spehr   +5 more
doaj   +1 more source

Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides. Whilst there is a wealth of literature
Birch, R. E., Peppiatt-Wildman, Claire M., Schwiebert, E. M., Wildman, Scott S.P.   +3 more
core   +2 more sources

Genomic Organization of Purinergic P2X Receptors

Pharmacology & Pharmacy, 2015
Purinergic P2X receptors are a family of ligand-gated cationic channels activated by extracellular ATP. P2X subunit protein sequences are highly conserved between vertebrate species. However, they can generate a great diversity of coding splicing variants to fulfill several roles in mammalian physiology.
Raúl Loera-Valencia, Josué Obed Jaramillo-Polanco, Andrómeda Linan-Rico, María Guadalupe Nieto Pescador, Juan Francisco Jiménez Bremont, Carlos Barajas-López   +5 more
openaire   +2 more sources

The effects of simulated childbirth trauma on the gene expression of neurotransmitter receptors in the bladder of female rats

Journal of the Formosan Medical Association, 2021
Background/Purpose: To investigate the effects of simulated childbirth on the gene expression of parasympathetic muscarinic, purinergic (P2X), and neurokinin receptors of lower urinary tract in rats.
Cheng-Yu Long, Kun-Ling Lin, Zi-Xi Loo, Chin-Ru Ker, Ming-Ping Wu, Yung-Chin Lee   +5 more
doaj   +1 more source