Results 141 to 150 of about 8,875 (174)

P2Y purinergic receptors regulate the growth of human melanomas

Cancer Letters, 2005
Adenosine 5'-triphosphate is known to function as a potent extracellular messenger producing its effects via a distinct family of cell surface receptors. Different receptor subtypes have been shown to modulate different cellular functions such as proliferation, differentiation and apoptosis.
Nicholas White, Mina Ryten, Peter Butler   +2 more
exaly   +3 more sources

G protein-coupled purinergic P2Y receptors in infectious diseases

Pharmacology & Therapeutics
The purinergic P2Y receptors comprise eight G-coupled receptor (GPCR) subtypes already identified (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12-14). P2Y receptor physiological agonists are extracellular purine and pyrimidine nucleotides such as ATP (Adenosine triphosphate), ADP (Adenosine diphosphate), UTP (Uridine triphosphate), UDP (Uridine diphosphate), and
Robson Coutinho-Silva, Luiz Eduardo Baggio Savio   +1 more
exaly   +3 more sources

Modulation of macrophage function by P2Y-purinergic receptors

Drug Development Research, 1996
Macrophage activation is central to the pathogenesis of a number of diseases that involve the excessive release of inflammatory mediators such as cytokines and nitric oxide (NO). Recent studies have shown that adenine nucleotides (ATP/ADP) and their receptors (P2 receptors, especially the P2Y class) are critically linked to macrophage responsiveness ...
Philip L. Fisette, Loren C. Denlinger, Richard A. Proctor, Paul J. Bertics   +3 more
openaire   +1 more source

Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung’s disease

Pediatric Surgery International, 2007
Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the intestine.
Anne-Marie, O' Donnell, Prem, Puri
openaire   +2 more sources

Biochemical Properties of a P_2Y‐Purinergic Receptor

Annals of the New York Academy of Sciences, 1990
The turkey erythrocyte has substantial value as a model for the study of a receptor that exhibits pharmacological properties very similar to those delineated in mammalian tissues for a P2Y-purinergic receptor. The G protein-dependent coupling of this receptor to phospholipase C can be studied in detail, and the availability of an abundant source of ...
T K, Harden, J L, Boyer, H A, Brown, C L, Cooper, R A, Jeffs, M W, Martin   +5 more
openaire   +2 more sources

The Phospholipase C Linked P2y-Purinergic Receptor

1990
The physiological effects of extracellular ATP and ADP have been broadly described for both the central nervous system and peripheral tissues (Burnstock, 1978; Burnstock and Kennedy, 1986; Gordon, 1986; Williams, 1987; Fleetwood and Gordon, 1987). In contrast to the clearly defined subtypes of P1-purinergic receptors (A1- and A2-receptors) responsible ...
J. L. Boyer, C. L. Cooper, M. W. Martin, G. L. Waldo, A. J. Morris, R. A. Jeffs, H. A. Brown, T. K. Harden   +7 more
openaire   +1 more source

Expression of a cloned P2Y purinergic receptor that couples to phospholipase C.

Molecular Pharmacology, 1994
P2Y purinergic receptors previously have been shown to couple either to activation of phospholipase C through a pertussis toxin-insensitive mechanism or to inhibition of adenylyl cyclase through pertussis toxin-sensitive members of the G1 family of G proteins.
T M, Filtz, Q, Li, J L, Boyer, R A, Nicholas, T K, Harden   +4 more
openaire   +2 more sources

NAADP+ is an agonist of the human P2Y11 purinergic receptor

Cell Calcium, 2008
Nicotinic acid adenine dinucleotide phosphate (NAADP+) is an intracellular second messenger releasing Ca2+ from intracellular stores in different cell types. In addition, it is also active in triggering [Ca2+](i) increase when applied extracellularly and various underlying mechanisms have been proposed.
ZOCCHI, ELENA, BRUZZONE, SANTINA, BODRATO N., USAI C., GUIDA, LUCREZIA, NICHOLAS R. A, KASSACK M. U., ZOCCHI E., DE FLORA, ANTONIO   +8 more
openaire   +4 more sources

P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall

NeuroReport, 1995
The tissues of the lateral wall of the cochlea, spiral ligament and stria vascularis, maintain homeostasis of the inner ear through the production of endolymph and regulation of cochlear blood flow. We examined the effects of purinergic agonists on the release of inositol phosphates (InsPs) in intact isolated lateral wall tissues of the Fischer-344 rat.
K, Ogawa, J, Schacht
openaire   +2 more sources

Purinergic P2X, P2Y and adenosine receptors differentially modulate hippocampal gamma oscillations

Neuropharmacology, 2012
The present study was designed to investigate the role of extracellular ATP and its receptors on neuronal network activity. Gamma oscillations (30-50 Hz) were induced in the CA3 region of acute rat hippocampal slices by either acetylcholine (ACh) or kainic acid (KA).
Steffen B, Schulz, Zin-Juan, Klaft, Anton R, Rösler, Uwe, Heinemann, Zoltan, Gerevich   +4 more
openaire   +2 more sources