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P2Y Purinergic Receptors, Endothelial Dysfunction, and Cardiovascular Diseases [PDF]

International Journal of Molecular Sciences, 2020
Purinergic G-protein-coupled receptors are ancient and the most abundant group of G-protein-coupled receptors (GPCRs). The wide distribution of purinergic receptors in the cardiovascular system, together with the expression of multiple receptor subtypes in endothelial cells (ECs) and other vascular cells demonstrates the physiological importance of the
Kurt R Stenmark, Anita Kovács-Kása, Róbert Bátori   +2 more
exaly   +4 more sources

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Transactivation of receptor tyrosine kinases by purinergic P2Y and adenosine receptors

Purinergic Signalling, 2022
Transactivation of receptor tyrosine kinases (RTK) is a crosstalk mechanism exhibited by G-protein-coupled receptors (GPCR) to activate signaling pathways classically associated with growth factors. The discovery of RTK transactivation was a breakthrough in signal transduction that contributed to developing current concepts in intracellular signaling ...
F G, Vázquez-Cuevas, M, Reyna-Jeldes, E, Velázquez-Miranda, C, Coddou   +3 more
openaire   +2 more sources

P2Y Purinergic Receptors Regulate the Growth of Human Melanomas

Cancer Letters, 2005
Adenosine 5'-triphosphate is known to function as a potent extracellular messenger producing its effects via a distinct family of cell surface receptors. Different receptor subtypes have been shown to modulate different cellular functions such as proliferation, differentiation and apoptosis.
Mina Ryten, Peter E M Butler
exaly   +3 more sources

G Protein-Coupled Purinergic P2Y Receptors in Infectious Diseases

Pharmacology & Therapeutics
The purinergic P2Y receptors comprise eight G-coupled receptor (GPCR) subtypes already identified (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12-14). P2Y receptor physiological agonists are extracellular purine and pyrimidine nucleotides such as ATP (Adenosine triphosphate), ADP (Adenosine diphosphate), UTP (Uridine triphosphate), UDP (Uridine diphosphate), and
Luiz Eduardo Baggio Savio, Robson Coutinho-Silva   +1 more
exaly   +3 more sources

Modulation of macrophage function by P2Y-purinergic receptors

Drug Development Research, 1996
Macrophage activation is central to the pathogenesis of a number of diseases that involve the excessive release of inflammatory mediators such as cytokines and nitric oxide (NO). Recent studies have shown that adenine nucleotides (ATP/ADP) and their receptors (P2 receptors, especially the P2Y class) are critically linked to macrophage responsiveness ...
Philip L. Fisette, Loren C. Denlinger, Richard A. Proctor, Paul J. Bertics   +3 more
openaire   +1 more source

Deficiency of purinergic P2Y receptors in aganglionic intestine in Hirschsprung’s disease

Pediatric Surgery International, 2007
Hirschsprung's disease is characterized by the absence of ganglion cells in the distal bowel and extends proximally for varying distances. In recent years, the purinergic P2Y receptors have begun to receive much attention as they have been recognised as major ATP receptors in many regions of the body, including the intestine.
Anne-Marie, O' Donnell, Prem, Puri
openaire   +2 more sources

Distribution of P2Y and P2X Purinergic Receptor Expression Within the Intestine

American Journal of Physiology - Renal Physiology
Several studies have revealed crucial roles for P2 receptors during inflammatory and infectious diseases, however, these have largely been demonstrated in immune cells and the enteric nervous system. Although epithelial cells serve as the first barrier against infection and inflammation, the role of purinergic signaling within the gastrointestinal ...
Joseph M Hyser, John Gebert, Kristen A Engevik   +2 more
exaly   +3 more sources