Results 181 to 190 of about 583,778 (211)

The Phospholipase C Linked P2y-Purinergic Receptor

1990
The physiological effects of extracellular ATP and ADP have been broadly described for both the central nervous system and peripheral tissues (Burnstock, 1978; Burnstock and Kennedy, 1986; Gordon, 1986; Williams, 1987; Fleetwood and Gordon, 1987). In contrast to the clearly defined subtypes of P1-purinergic receptors (A1- and A2-receptors) responsible ...
J. L. Boyer, C. L. Cooper, M. W. Martin, G. L. Waldo, A. J. Morris, R. A. Jeffs, H. A. Brown, T. K. Harden   +7 more
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Biochemical Properties of a P_2Y‐Purinergic Receptor

Annals of the New York Academy of Sciences, 1990
The turkey erythrocyte has substantial value as a model for the study of a receptor that exhibits pharmacological properties very similar to those delineated in mammalian tissues for a P2Y-purinergic receptor. The G protein-dependent coupling of this receptor to phospholipase C can be studied in detail, and the availability of an abundant source of ...
T K, Harden, J L, Boyer, H A, Brown, C L, Cooper, R A, Jeffs, M W, Martin   +5 more
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Expression of a Cloned P2Y Purinergic Receptor That Couples to Phospholipase C.

Molecular Pharmacology, 1994
P2Y purinergic receptors previously have been shown to couple either to activation of phospholipase C through a pertussis toxin-insensitive mechanism or to inhibition of adenylyl cyclase through pertussis toxin-sensitive members of the G1 family of G proteins.
Theresa M. Filtz, Robert A Nicholas, T K Harden   +2 more
exaly   +3 more sources

P2y purinergic receptors coupled to phosphoinositide hydrolysis in tissues of the cochlear lateral wall

NeuroReport, 1995
The tissues of the lateral wall of the cochlea, spiral ligament and stria vascularis, maintain homeostasis of the inner ear through the production of endolymph and regulation of cochlear blood flow. We examined the effects of purinergic agonists on the release of inositol phosphates (InsPs) in intact isolated lateral wall tissues of the Fischer-344 rat.
K, Ogawa, J, Schacht
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Purinergic P2X, P2Y and adenosine receptors differentially modulate hippocampal gamma oscillations

Neuropharmacology, 2012
The present study was designed to investigate the role of extracellular ATP and its receptors on neuronal network activity. Gamma oscillations (30-50 Hz) were induced in the CA3 region of acute rat hippocampal slices by either acetylcholine (ACh) or kainic acid (KA).
Steffen B, Schulz, Zin-Juan, Klaft, Anton R, Rösler, Uwe, Heinemann, Zoltan, Gerevich   +4 more
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NAADP+ is an agonist of the human P2Y11 purinergic receptor

Cell Calcium, 2008
Nicotinic acid adenine dinucleotide phosphate (NAADP+) is an intracellular second messenger releasing Ca2+ from intracellular stores in different cell types. In addition, it is also active in triggering [Ca2+](i) increase when applied extracellularly and various underlying mechanisms have been proposed.
ZOCCHI, ELENA, BRUZZONE, SANTINA, BODRATO N., USAI C., GUIDA, LUCREZIA, NICHOLAS R. A, KASSACK M. U., ZOCCHI E., DE FLORA, ANTONIO   +8 more
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Defective P2Y purinergic receptor function: A possible novel mechanism for impaired glucose transport

Journal of Cellular Physiology, 2003
AbstractExtracellular ATP is an ubiquitous mediator that regulates several cellular functions via specific P2 plasma membrane receptors (P2Rs), for which a role in modulating intracellular glucose metabolism has been recently suggested. We have investigated glucose uptake in response to P2Rs stimulation in fibroblasts from type 2 diabetic (T2D ...
Solini A., CHIOZZI, Paola, Morelli A., PASSARO, Angelina, FELLIN, Renato, DI VIRGILIO, Francesco   +5 more
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Focus on Molecules: Purinergic P2Y2 receptor

Experimental Eye Research, 2012
Ana, Guzman-Aranguez, Jesús, Pintor
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[SHP2 and MKP5 in P2Y purinergic receptor-mediated prostate cancer invasion].

Zhonghua bing li xue za zhi = Chinese journal of pathology, 2007
To investigate the effects of protein tyrosine phosphatase-SHP2 and dual-specificity MAPK phosphatase-MKP5 on the activation of MAPKs and cell invasion induced by P2Y purinergic receptor in human prostate cancer cell lines with different metastatic potentials.The wide type (-wt) SHP2, mutant type (-cs) SHP2 and wide type (-wt) MKP5 cDNA expression ...
Hui-ying, He, Jie, Zheng, Yan, Li, Wan-jie, Heng, Wei-gang, Fang   +4 more
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The P2Y purinergic receptor expressed by enteric neurones in guinea-pig intestine.

Neurogastroenterology and motility, 2006
Electrophysiological recording methods provided evidence for presynaptic release of ATP from enteric neurones and postganglionic sympathetic fibres in the enteric nervous system (ENS) of guinea-pig intestine (J Physiol Lond 2003; 550: 493-504). The released ATP acted at postsynaptic P2Y(1) receptors to evoke slow synaptic excitation in neurones in the ...
N, Gao, H-Z, Hu, M X, Zhu, X, Fang, S, Liu, C, Gao, J D, Wood   +6 more
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