Results 121 to 130 of about 6,211 (154)
Focal neuropathologies in the brain of COVID-19-infected humans: inflammation, primary gliovascular failure and microglial dysfunction. [PDF]
Signal Transduct Target TherIlles P, Yin HY, Tang Y.
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Characterization of Novel Variants in <i>P2YRY12, GP6</i> and <i>TBXAS1</i> in Patients with Lifelong History of Bleeding. [PDF]
BiomoleculesZamora-Cánovas A +12 more
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Molecular modeling of purinergic receptor P2Y12 and interaction with its antagonists
Journal of Molecular Graphics and Modelling, 2007Purinergic receptors are a class of cell surface receptors for purines that prefer ATP or ADP over adenosine. The surface receptors for extracellular nucleotides are called P2 receptors. They are activated by both pyrimidine and purine nucleotides. ADP initiates platelet aggregation by 'simultaneous activation of two G protein-coupled receptors, P2Y1 ...
Chenyang Zhan
exaly +3 more sources
Thrombosis and Haemostasis, 2015
SummaryP2Y12 receptor is required for sustained activation of integrin αllbβ3, irreversible platelet aggregation and thrombus stabilisation. Tetraspanin superfamily member CD151 associates with integrin aNbp3 and plays critical roles in regulation of thrombus growth and stability in vivo.
Denise Jackson +2 more
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SummaryP2Y12 receptor is required for sustained activation of integrin αllbβ3, irreversible platelet aggregation and thrombus stabilisation. Tetraspanin superfamily member CD151 associates with integrin aNbp3 and plays critical roles in regulation of thrombus growth and stability in vivo.
Denise Jackson +2 more
exaly +3 more sources
Thrombosis and Haemostasis, 2010
SummaryToll-like receptor 2 (TLR2), which recognise and respond to conserved microbial pathogen-associated molecular patterns, is expressed on the platelet surface. Furthermore, it has recently been shown that the TLR2/1 agonist Pam3CSK4 stimulates platelet activation.
Maria Lerm +2 more
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SummaryToll-like receptor 2 (TLR2), which recognise and respond to conserved microbial pathogen-associated molecular patterns, is expressed on the platelet surface. Furthermore, it has recently been shown that the TLR2/1 agonist Pam3CSK4 stimulates platelet activation.
Maria Lerm +2 more
exaly +3 more sources
P2Y12 but not P2Y13 Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo
Molecular Neurobiology, 2018Adenine nucleotides through P2Y1 receptor stimulation are known to control retinal progenitor cell (RPC) proliferation by modulating expression of the p57KIP2, a cell cycle regulator. However, the role of Gi protein-coupled P2Y12 and P2Y13 receptors also activated by adenine nucleotides in RPC proliferation is still unknown.
Lucianne Fragel-Madeira +2 more
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Thrombosis Research, 2018
Tumor-suppressing subchromosomal transferable fragment cDNA 6 (TSSC6) expression is restricted to hematopoietic organs and tissues where it plays a role in hematopoietic-cell function. The ADP purinergic receptor P2Y12 is mainly expressed by platelets with important clinical significance as a target for several clinically approved antithrombotic agents.
Denise Jackson +2 more
exaly +3 more sources
Tumor-suppressing subchromosomal transferable fragment cDNA 6 (TSSC6) expression is restricted to hematopoietic organs and tissues where it plays a role in hematopoietic-cell function. The ADP purinergic receptor P2Y12 is mainly expressed by platelets with important clinical significance as a target for several clinically approved antithrombotic agents.
Denise Jackson +2 more
exaly +3 more sources
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2023
Alzheimer's disease (AD) is a progressive neurodegenerative disease that is associated with protein misfolding, plaque accumulation, neuronal dysfunction, synaptic loss, and cognitive decline. The pathological cascade of AD includes the intracellular Tau hyperphosphorylation and its subsequent aggregation, extracellular Amyloid-β plaque formation and ...
Subashchandrabose, Chinnathambi +2 more
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Alzheimer's disease (AD) is a progressive neurodegenerative disease that is associated with protein misfolding, plaque accumulation, neuronal dysfunction, synaptic loss, and cognitive decline. The pathological cascade of AD includes the intracellular Tau hyperphosphorylation and its subsequent aggregation, extracellular Amyloid-β plaque formation and ...
Subashchandrabose, Chinnathambi +2 more
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A Comparison of Microglia Detection in Mammals and Humans Using Purinergic Receptor P2Y12 Labeling
Journal of Evolutionary Biochemistry and Physiology, 2021The problem of choosing an adequate method to detect microglia is relevant for modern neurophysiological and interdisciplinary research due to the lack of universal approaches allowing visualization of this cell population in the brain of humans and laboratory animals.
D. E. Korzhevskii +3 more
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