Results 101 to 110 of about 101,003 (237)

Effects of Quercetin Metabolites on Glucose‐Dependent Lipid Accumulation in 3T3‐L1 Adipocytes

Molecular Nutrition &Food Research, EarlyView.
Quercetin metabolites (QMs), found in foods like fruits and vegetables, can influence how fat cells process fats and sugars. This study shows that QMs help reduce fat storage and sugar uptake in fat cells when sugar levels are high. Under conditions mimicking caloric restriction, they boost sugar use for energy.
Marco Rendine, Samuele Venturi, Mirko Marino, Claudio Gardana, Peter Møller, Daniela Martini, Patrizia Riso, Cristian Del Bo   +7 more
wiley   +1 more source

Oral Delivery of Ellagic Acid Encapsulated in Milk Exosomes: Sex‐Based Differences in Bioavailability, Urolithin Production, and Gut Microbiota Modulation

Molecular Nutrition &Food Research, EarlyView.
Sex‐dependent effects on plasma metabolome and gut microbiota were observed after oral administration of ellagic acid (EA) encapsulated in milk‐derived exosomes (EXO‐EA) versus non‐encapsulated EA (NEA) and non‐loaded EXOs. EXO‐EA impacted plasma metabolome, modulated gut microbiota, and increased urolithin A and SCFA production sex‐dependently ...
María Ángeles Ávila‐Gálvez, María Romo‐Vaquero, Carmen Mazarío‐Gárgoles, Joao Tomé‐Carneiro, María‐Carmen López de las Hazas, Alberto Dávalos, María Victoria Selma, Antonio González‐Sarrías, Juan Carlos Espín   +8 more
wiley   +1 more source

NIR‐Induced Photoswitching Hybrid DNA Nanoconstruct‐Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate

Small, EarlyView.
NIR‐mediated photo‐switching drug delivery system for the remote‐control differentiation of NSCs. Left: NIR‐mediated curcumin release is induced by NIR‐to‐UV photon upconversion in a photo‐controllable manner. Curcumin is bound in the minor groove of the synthesized DNA construct containing AAP photo‐switchers. Right: The rational design of several AAP
Thanapat Pongkulapa, Ji Hye Yum, Callan D. McLoughlin, Brandon Conklin, Tomotaka Kumagai, Li Ling Goldston, Hiroshi Sugiyama, Soyoung Park, Ki‐Bum Lee   +8 more
wiley   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Single‐cell spatial transcriptomic sequencing and machine learning models uncover molecular mechanisms and diagnostic biomarkers of Peyronie's disease formation in rats

VIEW, EarlyView.
Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou, Qiancheng Mao, Junpeng Chi, Jiankun Zhang, Hao Guo, Jitao Wu, Yuanshan Cui   +6 more
wiley   +1 more source

Role of NRP1/HDAC4/CREB/RIPK1 Axis in SARS‐CoV2 S1 Spike Subunit‐Induced Neuronal Toxicity

FASEB BioAdvances, EarlyView.
Extracellular SARS‐CoV2 Spike‐S1 protein via NRP1 internalizes in the cytosol of SH‐SY5Y cells. Once inside, it upregulates the epigenetic eraser HDAC4, which binds transcriptional factor CREB, causes RIPK1 up‐regulation, and therefore necroptotic cell death.
Luca Sanguigno, Natascia Guida, Mariarosaria Cammarota, Silvia Ruggiero, Angelo Serani, Francesca Galasso, Vincenzo Pizzorusso, Francesca Boscia, Luigi Formisano   +8 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Mechanistic Insights Into 5′‐tiRNA‐His‐GTG Mediated Activation of the JNK Pathway in Skin Photoaging

Aging Cell, EarlyView.
5′‐tiRNA‐His‐GTG expression level is upregulated in the photoaging cell model. 5′‐tiRNA‐His‐GTG negatively regulates the expression of NUP98, thereby activating the JNK signaling pathway to regulate cell senescence. ABSTRACT UV exposure leads to skin damage, thus inducing skin aging.
Lihao Liu, Zhuohong Xu, Xiaoxi Dai, Xuyue Zhou, Lihao Chen, Chao Luan, Dan Huang, Hongying Chen, Jiaan Zhang, Yu Hu, Kun Chen   +10 more
wiley   +1 more source

Systematic Review of Rare Major Adverse Cardiovascular Events Associated With the Treatment of Acne With Isotretinoin

Australasian Journal of Dermatology, Volume 66, Issue 3, Page e97-e108, May 2025.
ABSTRACT Acne vulgaris is a common inflammatory condition that is often treated by dermatologists with isotretinoin. Isotretinoin has a number of effects on inflammatory pathways, with clear efficacy in managing acne vulgaris. There are also well‐documented side effects of isotretinoin, including hyperlipidemia; however, the overall cardiovascular risk
Timothy L. Cowan, Madeleine Stark, Simona Sarmiento, Andrew Miller   +3 more
wiley   +1 more source

Therapeutic Uses of Retinol and Retinoid-Related Antioxidants. [PDF]

Molecules
Vašková J, Stupák M, Vidová Ugurbaş M, Židzik J, Mičková H.   +4 more
europepmc   +1 more source