Results 121 to 130 of about 57,506 (257)

MAVS oligomerization drives a faster and more efficient antiviral signaling activation at peroxisomes compared to mitochondria

The FEBS Journal, EarlyView.
Cells rely on mitochondria and peroxisomes to trigger antiviral defenses via the protein MAVS. This manuscript demonstrates that the robust production of antiviral effectors resulting from MAVS activation at peroxisomes is faster than at mitochondria due to a swifter oligomerization of this protein at peroxisomal membranes. These results underscore the
Bruno Ramos, Jéssica Sarabando, Mariana Marques, Jonathan C. Kagan, Daniela Ribeiro   +4 more
wiley   +1 more source

Protein truncating splice site variant in <i>ALDH1A3</i> associated with bilateral anophthalmia identified in a multiplex consanguineous Pakistani family. [PDF]

Int J Ophthalmol
Samad K, Alzahrani KJ, Alsharif KF, Samad F, Ullah F, Ali MZ, Ahmad S, Muzammal M, Abbasi SW, Khan J, Khan MA.   +10 more
europepmc   +1 more source

3′UTR variants of ALS‐linked RNAs modify subcellular and cellular phenotypes

The FEBS Journal, EarlyView.
Our study demonstrates that alternative 3′UTR variants of ALS‐linked transcripts modulate subcellular RNA localization and cytoskeletal architecture. NEFH 3′UTR‐Long promotes nuclear RNA clustering, while SOD1 3′UTR‐Long reduces filopodia formation. These results suggest that 3′UTRs, independent of coding sequences, can influence neuronal phenotypes ...
Melis Savasan‐Sogut, Danae Campos‐Melo, Michael J. Strong   +2 more
wiley   +1 more source

Anti-DNA Damage Mechanisms and the Role of Carotenoids, Vitamin A, and Its Derivatives. [PDF]

Nutrients
Kołodziejczyk AM, Karwowski B.
europepmc   +1 more source

Regulation of PHOX2B gene expression by the long non‐coding natural antisense RNA PHOX2B‐AS1

The FEBS Journal, EarlyView.
PHOX2B is a transcription factor essential for autonomic nervous system development. We identify and characterize PHOX2B‐AS1, a human long non‐coding antisense transcript at the PHOX2B locus, along with its murine counterpart. Our findings reveal bidirectional transcription and reciprocal regulation: PHOX2B activates PHOX2B‐AS1, whereas PHOX2B‐AS1 ...
Simona Di Lascio, Ana Lucia Cuadros Gamboa, Martina Bertocchi, Filippo Chiesa, Francesca Cargnin, Ettore Mosca, Paride Pelucchi, Viviana Tritto, Stefania Corti, Isabella Ceccherini, Paola Riva, Roberta Benfante, Diego Fornasari   +12 more
wiley   +1 more source

Interactive Effects of Vitamin A and All-Trans Retinoic Acid on Growth Performance, Intestinal Health, and Plasma Metabolomics of Broiler Chickens. [PDF]

Animals (Basel)
Guo S, Xiong Y, He L, Yan J, Li P, Li C, Ding B.   +6 more
europepmc   +1 more source

Bioretinoids from microalgae: Boosting retinol performance and tolerability

International Journal of Cosmetic Science, EarlyView.
A novel microalgae‐derived bioretinoid (MBR) enhances skin regeneration, improves pigmentation, and reduces signs of ageing more effectively than bakuchiol and comparably to retinol—without the irritation. MBR also synergizes with retinol, boosting hydration and safety. A powerful, gentle alternative for advanced skincare.
Silvia Sánchez‐Díez, Alexandre Lapeyre, Noemí García‐Delgado, Jordi Ayats   +3 more
wiley   +1 more source

Bexarotene signaling in human B and T lymphocytes induces gut-homing receptor expression. [PDF]

Front Immunol
Kaiser S, Suhrkamp I, He J, Helf C, Sadik CD, Weichenthal M, Heine G.   +6 more
europepmc   +1 more source

Melatonin and the Dental Pulp: A Scoping Review

International Endodontic Journal, EarlyView.
ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer, Konrad Kleszczynski, Edgar Schäfer   +2 more
wiley   +1 more source

Combination therapy based on venetoclax overcomes resistance to all-trans retinoic acid and arsenic trioxide in a variant acute promyelocytic leukemia with TNRC18::RARA fusion. [PDF]

Ann Hematol
Ding W, Zhao J, Wang Z, Liu Y, Wang M, Shen H, Chen Y, Huang J, Li D, Chen S, Wen L.   +10 more
europepmc   +1 more source