Results 131 to 140 of about 101,003 (237)

Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells. [PDF]

Front Pharmacol
Yang Y, Zhou J, Lv Q, Ni Q, Hu B, Wang Y, Qu S, Li G, Yang W, Zhong R, Chen X, Zhu Y.   +11 more
europepmc   +1 more source

Immunosuppressive Effects of Multiple Myeloma‐Derived Extracellular Vesicles Through T Cell Exhaustion

Cancer Science, EarlyView.
Extracellular vesicles (EVs) derived from myeloma cells could potentially induce T cell exhaustion via the increase of the frequency of immune checkpoint marker‐positive CD8+ T cells and might thereby suppress T cell function. In addition, this immune escape mechanism from cytotoxic T cells is supported by the findings on SPHK1/S1P signaling from SPHK1‐
Shinya Hagiwara, Masaki Ri, Toru Ebina, Yoshiaki Marumo, Tomoyuki Nakamura, Kentaro Hirade, Takahiro Nakashima, Arisa Asano, Shiori Kinoshita, Tomotaka Suzuki, Tomoko Narita, Ayako Masaki, Hirokazu Komatsu, Shinsuke Iida   +13 more
wiley   +1 more source

Vitamin A and its influence on tumour extracellular matrix. [PDF]

Discov Oncol
Xie G, Cao S, Wang G, Zhang X, Zhang Y, Wu H, Shen S, Le J, Li K, Huang Z.   +9 more
europepmc   +1 more source

The Emerging Oncogenic Role of RARγ: From Stem Cell Regulation to a Potential Cancer Therapy. [PDF]

Int J Mol Sci
Brown G.
europepmc   +1 more source

Klotho Regulates Club Cell Senescence and Differentiation in Chronic Obstructive Pulmonary Disease

Cell Proliferation, EarlyView.
We speculated lack of Klotho (KL) would aggravate club cell senescence, which contributes to COPD inflammation. In this study, we collected chronic obstructive pulmonary disease (COPD) lung tissue using single‐cell RNA sequencing (scRNA‐seq), revealing club cell heterogeneity and cellular senescence in COPD.
Min Li, Bo Chen, Sibo Sun, Kai Wang, Yu Wang, Jianqing Wu   +5 more
wiley   +1 more source

Editorial: The role of retinoic acid signaling in maintenance and regeneration of the CNS: from mechanisms to therapeutic targeting. [PDF]

Front Mol Neurosci
Corcoran JPT, Mey J.
europepmc   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, EarlyView.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Apoptotic clearance by stem cells: molecular mechanisms for recognition and phagocytosis of dead cells. [PDF]

Signal Transduct Target Ther
Liu F, Zhou X, Akin I.
europepmc   +1 more source

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source

Polyoxyethylene and polypropylene emulsification enhances retinol palmitate efficacy in corneal wound healing. [PDF]

Sci Rep
Horiuchi H, Watanabe K, Iijima H, Obayashi Y.   +3 more
europepmc   +1 more source